Results 51 to 60 of about 881,840 (317)

Critical Changes in Cortical Neuronal Interactions in Anesthetized and Awake Rats [PDF]

, 2015
Background: Neuronal interactions are fundamental for information processing, cognition and consciousness. Anesthetics reduce spontaneous cortical activity; however, neuronal reactivity to sensory stimuli is often preserved or augmented.
Hudetz, Anthony G., Pillay, Siveshigan, Ropella, Kristina M., Vizuete, Jeannette A.   +3 more
core   +2 more sources

Reduced neural activity during volatile anesthesia compared to TIVA: evidence from a novel EEG signal processing analysis [PDF]

arXiv, 2020
Post-operative cognitive decline is a well-known phenomenon and of crucial importance especially in the elderly. General anesthesia can be accomplished by inhalation-based (volatile) or total intravenous anesthesia (TIVA). While their effects on post-operative symptoms have been investigated, little is known about their influence on brain ...
arxiv  

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Postoperative malignant hyperthermia confirmed by calcium-induced calcium release rate after breast cancer surgery, in which prompt recognition and immediate dantrolene administration were life-saving: a case report

Journal of Medical Case Reports, 2021
Background Malignant hyperthermia (MH) is a rare genetic disease characterized by the development of very serious symptoms, and hence prompt and appropriate treatment is required. However, postoperative MH is very rare, representing only 1.9% of cases as
Natsumi Miyazaki, Takayuki Kobayashi, Takako Komiya, Toshio Okada, Yusuke Ishida, Hidekimi Fukui, Yukihiko Ogihara, Hiroyuki Uchino   +7 more
doaj   +1 more source

Transient neurologic symptoms following spinal anesthesia with isobaric mepivacaine: A decade of experience at Toronto Western Hospital [PDF]

, 2018
Background: Transient neurologic symptoms (TNSs) can be distressing for patients and providers following uneventful spinal anesthesia. Spinal mepivacaine may be less commonly associated with TNS than lidocaine; however, reported rates of TNS with ...
Abdallah, Faraj W., Behboudi, Minou, Brull, Richard, MacFarlane, Alan, Sankar, Ashwin   +4 more
core   +2 more sources

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Cardiovascular changes after administration of aerosolized salbutamol in horses: five cases [PDF]

, 2014
Prevention and treatment of intraoperative hypoxemia in horses is difficult and both efficacy and safety of therapeutic maneuvers have to be taken into account.
AE Wagner, Chiara Adami, Claudia Spadavecchia, Daniela Casoni, E Spiekerkoetter, EM Kallergis, FJ Derksen, G Nyman, G Nyman, G Nyman, H-M Palos, J Horn, JG Baker, JR Dodam, K Toerneke, K Toerneke, KJ Whitehair, KJ Whitehair, L Devisscher, M Patschova, MA Gaballa, MR Bristow, OE Brodde, SA Robertson, YH Lee   +24 more
core   +4 more sources

Hysteresis in anesthesia and recovery: Experimental observation and dynamical mechanism [PDF]

arXiv, 2020
The dynamical mechanism underlying the processes of anesthesia-induced loss of consciousness and recovery is key to gaining insights into the working of the nervous system. Previous experiments revealed an asymmetry between neural signals during the anesthesia and recovery processes.
arxiv  

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Low tidal volume ventilation for patients undergoing laparoscopic surgery: a secondary analysis of a randomised clinical trial

BMC Anesthesiology, 2023
Background We recently reported the results for a large randomized controlled trial of low tidal volume ventilation (LTVV) versus conventional tidal volume (CTVV) during major surgery when positive end expiratory pressure (PEEP) was equal between groups.
Dharshi Karalapillai, Laurence Weinberg, Ary Serpa Neto, Philip J. Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong O. Tan, David Story, Mark O’Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Grace Liskaser, Ajay Balasubramaniam, Glenn Eastwood, Rinaldo Bellomo, Daryl A. Jones   +18 more
doaj   +1 more source