Results 201 to 210 of about 343,216 (264)

Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration

Advanced Science, EarlyView.
These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma, Chen Lei, Tao Ye, Qian‐Qian Wan, Kai‐Yan Wang, Yi‐Na Zhu, Ling Li, Xu‐Fang Liu, Long‐Zhang Niu, Franklin R. Tay, Zhao Mu, Kai Jiao, Li‐Na Niu   +12 more
wiley   +1 more source

Comparison of the effects of lidocaine and articaine used for buccal infiltration and supplemental palatinal infiltration anesthesia in maxillary molars with irreversible pulpitis: a prospective randomized study. [PDF]

BMC Oral Health
Kolay D, Kırıcı D.
europepmc   +1 more source

In Vivo Reprogramming of Tissue‐Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering

Advanced Science, EarlyView.
Inspired by exercise‐induced metabolic rewiring and EV secretion, this study shows that in vivo metabolic engineering strategy can reprogram EV secretion pattern and simultaneously attenuate multiple tissue injury in CKD status, highlighting that it is a potential strategy for treating diverse chronic diseases.
Meng Zhao, Shuyun Liu, Yizhuo Wang, Peng Lou, Ke Lv, Tian Wu, Lan Li, Qianyi Wu, Jiaying Zhu, Yanrong Lu, Meihua Wan, Jingping Liu   +11 more
wiley   +1 more source

The Utilization of Ultrasound-Guided Regional Nerve Blocks in Anesthetic Management for Fracture Surgery. [PDF]

J Pain Res
Yi R, Li Z, Yang X, Huang T, Liu H, Zhang J.   +5 more
europepmc   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Genetic Variation and Sex-Based Differences: Current Considerations for Anesthetic Management. [PDF]

Curr Issues Mol Biol
DiMaria S, Mangano N, Bruzzese A, Bartula B, Parikh S, Costa A.   +5 more
europepmc   +1 more source

An Off‐the‐Shelf Artificial Proregenerative Macrophage for Pressure Ulcer Treatment

Advanced Science, EarlyView.
Artificial macrophages (artM) by encapsulating M2 lysates into biodegradable PLGA microspheres and coated with macrophage membrane, are engineered as new therapeutics against skin pressure ulcer. In mouse models, the artM exhibited robust tissue repair through cell recruitment and microenvironment modulation, showing great therapeutic potential for ...
Qi Su, Jingrong Wang, Yini Huangfu, Rui Gao, Pengxu Kong, Yu Gao, Huijuan Song, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Zujian Feng, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Myocardial Infarction and Subdural Hematoma Presenting a Neurosurgical Anesthetic Challenge: Successful Management With Scalp Block and Dexmedetomidine Infusion. [PDF]

Cureus
Postiga A, Coutinho ML, Portela E Silva R, Almeida C, Matias F.   +4 more
europepmc   +1 more source

Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects

Advanced Science, EarlyView.
This study introduces the SF‐ZIF@NA hydrogel system for osteoporotic bone defect treatment. The hydrogel inhibits osteoclast fusion by removing sialic acid and preserves the anabolic function of precursor osteoclasts (pOCs). It also releases Zn2⁺ in acidic conditions, promoting osteogenesis and angiogenesis.
Zhengrong Chen, Wenxin Yang, Yong Tang, Qianqian Dong, Kui Huang, Jiulin Tan, Jie Zhang, Juan Cai, Qixiu Yu, Qijie Dai, Jianzhong Xu, Shuquan Guo, Ce Dou, Fei Luo   +13 more
wiley   +1 more source

Effects of pericapsular nerve group block versus local anesthetic infiltration for postoperative analgesia in total hip arthroplasty: A protocol for systematic review and meta-analysis. [PDF]

PLoS One
Rong L, Qin T, Yu S, Zhang D, Wei Y.
europepmc   +1 more source