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Local anesthetic systemic toxicity: current perspectives
Local and Regional Anesthesia, 2018 Local anesthetic systemic toxicity (LAST) is a life-threatening adverse event that may occur after the administration of local anesthetic drugs through a variety of routes.
K. El-Boghdadly, A. Pawa, K. Chin
semanticscholar +1 more source
Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence
Journal of Translational Medicine, 2018 The relationship between surgery and anesthetic-induced immunosuppression and cancer recurrence remains unresolved. Surgery and anesthesia stimulate the hypothalamic–pituitary–adrenal (HPA) axis and sympathetic nervous system (SNS) to cause ...
R. Kim
semanticscholar +1 more source
Genetic study in patients operated dentally and anesthetized with articaine-epinephrine [PDF]
, 2019 Aims: In this study we wanted to figure out if there was a correlation between OPRM1 N40D, TRPV1 I316M, TRPV1 I585V, NOS3 −786T>C and IL6 −174C>G polymorphisms and the response to locally applied articaine-epinephrine anesthetic.
Cieza-Borrella, C +5 more
core +2 more sources
Soluble α-Klotho Serum Levels in Chronic Kidney Disease
International Journal of Endocrinology, 2015 Transmembrane α-Klotho (TM-Klotho), expressed in renal tubules, is a cofactor for FGF23-receptor. Circulating soluble-α-Klotho (s-Klotho) results from TM-Klotho shedding and acts on Phosphate (P) and Calcium (Ca) tubular transport.
Silverio Rotondi +8 more
doaj +1 more source
Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. [PDF]
, 2017 BackgroundGastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation.ObjectiveTo determine whether pre-anesthetic orally administered omeprazole ...
Belafsky, PC +8 more
core +3 more sources
General Anaesthesia and Emergency Surgery in Heart Transplant Recipient
Case Reports in Surgery, 2015 The number of patients who undergo heart transplant is increasing. Due to surgical emergencies, many of those may require general anesthesia in hospitals where subspecialized anesthetists may not be available.
Farshid Ejtehadi +4 more
doaj +1 more source
Chiral Alkyl Halides: Underexplored Motifs in Medicine
Marine Drugs, 2016 While alkyl halides are valuable intermediates in synthetic organic chemistry, their use as bioactive motifs in drug discovery and medicinal chemistry is rare in comparison. This is likely attributable to the common misconception that these compounds are
Bálint Gál +2 more
doaj +1 more source
Assessment of Three Anesthetics Used for Pulmonary Pharmacological Studies in Rats
Journal of Applied Veterinary Sciences, 2022 Experiments on pulmonary pharmacology are often performed in laboratory animals. Investigators collect organs, samples, or record modifications in the respiratory system during anaesthesia, which might significantly influence the data attained.
Gareeballah Osman Adam
doaj +1 more source
Are Local Anesthetics and General Anesthetics Different? [PDF]
Biophysical Journal, 2014 It is widely believed that general and local anesthetics act by different mechanisms. While there is general agreement that the mode of action of general anesthetics is poorly understood, local anesthetics are believed to block voltage-gated sodium channels and thereby affect action potentials in nerves.
Sasse-Middelhoff, Henrike +2 more
openaire +2 more sources