Results 21 to 30 of about 470,729 (391)

Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells

Frontiers in Pharmacology, 2023
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent protein ...
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Soshi Narasaki, Tomoaki Urabe, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai   +15 more
doaj   +1 more source

Smart needle electrical bioimpedance to provide information on needle tip relationship to target nerve prior to local anesthetic deposition in peripheral nerve block (USgPNB) procedures

Journal of Electrical Bioimpedance, 2023
Ultrasound guided peripheral nerve block (USgPNB) refers to anaesthetic techniques to deposit local anesthetic next to nerves, permitting painful surgery without necessitating general anesthesia.
Whelton Edel, Helen Lisa, O’Donnell Brian, O’Sullivan Martin, Ugwah Justina, Messina Walter, Wang Yineng, O’Mahoney Niamh, Moore Eric   +8 more
doaj   +1 more source

Mechanistic insights into volatile anesthetic modulation of K2P channels

eLife, 2020
K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia.
Aboubacar Wague, Thomas T Joseph, Kellie A Woll, Weiming Bu, Kiran A Vaidya, Natarajan V Bhanu, Benjamin A Garcia, Crina M Nimigean, Roderic G Eckenhoff, Paul M Riegelhaupt   +9 more
doaj   +1 more source

The Use of Awake Videolaryngoscopy and an Innovative Flexible-Tipped Bougie in a Potentially Difficult Airway

Case Reports in Anesthesiology, 2020
We present a case where awake videolaryngoscopy (VL) was used, along with a flexible-tipped bougie to allow endotracheal intubation in a challenging airway. The patient presented for resection of a large left-sided parapharyngeal mass.
Will A. Watson, John Cormack
doaj   +1 more source

The validity of topical drug therapy for otitis media with effusion

Медицинский совет, 2021
Otitis media with effusion is difficult to diagnose, since the course of the disease is mostly asymptomatic, while the initial stage of the disease is very similar to Eustachiitis or the pre-perforative stage of acute otitis media.
S. V. Morozova, K. V. Eremeeva, W. H.A. Suaifan   +2 more
doaj   +1 more source

Perioperative and anesthetic deaths: toxicological and medico legal aspects [PDF]

, 2019
Background: Anesthesia has become safer during decades, though there is still a preventable mortality; the complexity of medical and surgical interventions, increasingly older and sicker patients, has created a host of new hazards in anesthesiology.
Argo A., Buscemi R., Karch S. B., Lanzarone A., Roccuzzo R., Zerbo S.   +5 more
core   +1 more source

Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery: The ENGAGES Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2019
Importance Intraoperative electroencephalogram (EEG) waveform suppression, often suggesting excessive general anesthesia, has been associated with postoperative delirium.
T. Wildes, Angela M. Mickle, A. Ben Abdallah, H. Maybrier, Jordan Oberhaus, T. Budelier, A. Kronzer, S. McKinnon, Daniel Park, Brian A. Torres, T. Graetz, D. Emmert, B. Palanca, Shreya Goswami, Katherine Jordan, N. Lin, Bradley A. Fritz, T. Stevens, E. Jacobsohn, E. Schmitt, S. Inouye, S. Stark, E. Lenze, M. Avidan   +23 more
semanticscholar   +1 more source

Isoflurane induces Art2‐Rsp5‐dependent endocytosis of Bap2 in yeast

FEBS Open Bio, 2021
Although general anesthesia is indispensable during modern surgical procedures, the mechanism by which inhalation anesthetics act on the synaptic membrane at the molecular and cellular level is largely unknown.
Fumi Kozu, Kanae Shirahama‐Noda, Yasuhiro Araki, Shintaro Kira, Hitoshi Niwa, Takeshi Noda   +5 more
doaj   +1 more source

Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. [PDF]

, 2017
BackgroundGastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation.ObjectiveTo determine whether pre-anesthetic orally administered omeprazole ...
Belafsky, PC, Della Maggiore, A, Fulton, A, Garcia, RS, Marks, SL, Osborn, JM, Pierce, T, Pypendop, BH, Walker, VJ   +8 more
core   +3 more sources

Immune‐Mediated Myocarditis in Fabry Disease Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Glycosphingolipid accumulation in Fabry cells generates a proinflammatory response that may influence disease evolution and responsiveness to enzyme replacement therapy.
Andrea Frustaci, Romina Verardo, Claudia Grande, Nicola Galea, Pierluca Piselli, Iacopo Carbone, Maria Alfarano, Matteo Antonio Russo, Cristina Chimenti   +8 more
doaj   +1 more source