Results 221 to 230 of about 18,313 (287)

Spinal cord transection repair occurs when Nestin+ cells differentiate into neurons within a taxol‐collagen‐enhanced microenvironment in mice

Neuroprotection, EarlyView.
We utilized Nestin‐CreER:tdTomato transgenic mice to directly illustrate that taxol could induce the differentiation of neural stem cells (NSCs) into neurons. This process promoted the formation of a nerve bridge connecting the two ends of the injury, ultimately resulting in the functional improvement of spinal cord injury (SCI) animals.
Caixia Fan, He Jiang, Junyan Yan, Lifang Jin, Guoquan Fu, Weiwei Xue, Lulu Zhang   +6 more
wiley   +1 more source

Volatile anesthetics in the intensive care unit. [PDF]

Anaesthesiol Intensive Ther
Morrison-Nozik A, Wąsowicz M.
europepmc   +1 more source

Predicting Anxiety in Children Aged 2–6 During Preoperative Anesthesia Consultation—A Prospective Observational Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Preoperative Anxiety in Young Children Is Common and Can Lead to Adverse Outcomes. In Clinical Routine, Anesthesiologists Must Often Predict Anxiety Based on Limited Interaction. Aims This study aimed to evaluate the accuracy of early anxiety predictions and to identify early predictors of heightened anxiety at anesthesia induction.
Armin Sablewski, Charlotte Neitzel, Maximilian Grosser, Katarina Krebs, Anna Karstensen, Alina Balandin, Helene Selpien, Tobias Becher   +7 more
wiley   +1 more source

Evaluation of the effectiveness of GASMAN anesthesia simulation software combined with case-based learning versus traditional lecture-based learning in inhalation anesthesia education. [PDF]

Front Med (Lausanne)
Chen C, Yang S, Xiong X, Shi Y, Zhu Z, Shi J.   +5 more
europepmc   +1 more source

Glucocorticoid‐Induced TNFR‐Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children

Pediatric Discovery, EarlyView.
Our study demonstrates elevated GITRL expression in HDM‐exposed dendritic cells (in vitro), murine asthma models, and pediatric asthma patients, and reveals a direct association between GITRL levels and disease severity in children. ABSTRACT Currently, there are no reliable pediatric biomarkers for assessing the severity of asthma. Therefore, the study
Yuehan Li, Yan Li, Jinying Xiang, Yinying Ren, Mi Zhou, Fang Deng, Zhou Fu, Fengxia Ding   +7 more
wiley   +1 more source

Suzetrigine - A Novel FDA-Approved Analgesic - Opportunities, Challenges and Future Perspectives: A Perspective Review. [PDF]

Health Sci Rep
Mohiuddin AL, Ahmed Z.
europepmc   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Mechanisms by which sevoflurane affects cognitive function in aged marmosets and mice: up-regulation of FKBP5 expression in brain microglia. [PDF]

Med Gas Res
Zhang L, Zhu J, Miao Z, Mao H, Jiang H.
europepmc   +1 more source

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

Small, EarlyView.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha, Yeonji Kim, Subin Park, Hu‐Lin Jiang, Jae‐Young Lee, Daesik Kim, Jee‐Heon Jeong   +6 more
wiley   +1 more source

Impact of desflurane versus isoflurane on early cognitive function of the elderly undergoing lumbar surgery: a randomized clinical trial. [PDF]

BMC Anesthesiol
Jin D, Ma Y, Ji Y, Ge S.
europepmc   +1 more source