Results 191 to 200 of about 40,984 (314)

Strategic Timing of Gene Silencing: Cellular Kinetics‐Based Administration of siRNA for Optimized Photothermal Cancer Treatment

Advanced Science, EarlyView.
Coordinating therapy with gene expression kinetics emerges as a key strategy for maximizing nanomedicine efficacy in aggressive cancers. A hybrid nanocarrier delivering HSP70‐targeting siRNA demonstrates this chronotherapeutic principle through systematic cellular profiling.
Tianliang Fang, Li Li, Ziyad Tariq Muhseen, Lucas A. Lane, Huiming Cai, Christopher J. Butch, Yiqing Wang   +6 more
wiley   +1 more source

Minimum alveolar concentration of sevoflurane with a rapid intravenous administration of dexmedetomidine for deep extubation in children. [PDF]

BMC Anesthesiol
Guo J, Wan Y, Wang X, Shi Y.
europepmc   +1 more source

Targeting of the CD161 Inhibitory Receptor Enhances Bone‐Marrow‐Resident Memory CD8+ T‐Cell‐Mediated Immunity against Multiple Myeloma

Advanced Science, EarlyView.
CD161 is identified as a novel inhibitory receptor on bone marrow (BM)‐resident CD8⁺ T cells in multiple myeloma (MM). Through interaction with its ligand CLEC2D, CD161 impairs T‐cell function and promotes immune suppression. Blockade of CD161 restores tissue residency and cytotoxicity of CD8⁺ T cells and enhances chimeric antigen receptor T‐cell (CAR ...
Liwen Wang, Linzhi Xie, Yi Zhou, Shiming Tan, Yan Yu, Qin Zhang, Xuefeng Chen, Yuhan Yan, Ruiheng Luo, Han Xiao, Qian Cheng, Jian Zhang, Ying Li, Erhua Wang, Tiebin Jiang, Jing Liu, Xin Li   +16 more
wiley   +1 more source

Efficacy evaluation of neuromuscular blocking agents as adjuncts to intravenous regional anesthesia: a meta-analysis of randomized controlled trials. [PDF]

Front Med (Lausanne)
Yang Y, Sun S, Song G, Zhang J, Chen R.
europepmc   +1 more source

A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis

Advanced Science, EarlyView.
The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong, Shuguang Yang, Xiao Li, Zhuang Jin, Jianyu Ma, Zhouzhou Liao, Jinbo Li, Bo Li, Xintao Shuai, Shuqin Chen   +9 more
wiley   +1 more source

The Impact of Total Intravenous Anesthesia and Volatile Anesthetics on Minimizing Cancer Recurrence and Postoperative Cognition. [PDF]

Cureus
Jin IH, Lew MW.
europepmc   +1 more source

PDZK1 Protects Against RPE Senescence by Targeting the 14‐3‐3ε‐mTOR Axis to Attenuate Early Diabetic Retinopathy

Advanced Science, EarlyView.
PDZK1 down‐regulation couples high‐glucose stress to RPE senescence via a PDZK1–14‐3‐3ε–mTOR axis. Restoring PDZK1 or clearing senescent cells rescues retinal homeostasis and mitigates early diabetic retinopathy (DR). This study provides direct evidence linking RPE cell senescence to DR pathogenesis and reveals a promising therapeutic strategy for DR ...
Jian Zhao, Junbiao Zhang, Yanli Liu, Lili Wang, Chunxi Huang, Wei Chi, Meixia An   +6 more
wiley   +1 more source

Pain Control Paradigms: A Comparative Review of Anesthesia Techniques in Trigeminal Neuralgia Therapy. [PDF]

Pain Ther
Lai L, Xie K.
europepmc   +1 more source

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

Advanced Science, EarlyView.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen, Yiming Huang, Yang Zhang, Chunhao Yu, Hanqi Liu, Dong Bian, Di Wu, Wu Wang, Xunming Ji, Yufeng Zheng, Miaowen Jiang, Ming Li   +11 more
wiley   +1 more source

The effect of intravenous lignocaine infusion on intraoperative desflurane requirement: A randomised controlled trial. [PDF]

Medicine (Baltimore)
Sayed Masri SNN, Matthew Rona WA, Muhamad Suhaini NA, Mohamad Yusof A, Budiman M, Masdar A, Izaham A.   +6 more
europepmc   +1 more source