Results 211 to 220 of about 736,541 (316)

Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis

open access: yesArthritis &Rheumatology, EarlyView.
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato   +9 more
wiley   +1 more source

Sustained IFN Signature Suppression with Anifrolumab in a SAVI patient Refractory to JAK Inhibitor and Dazukibart Therapy

open access: yesArthritis &Rheumatology, Accepted Article.
Objective To report the efficacy and safety of interferon‐β (IFNβ) neutralizing monoclonal antibody (dazukibart), followed by treatment with anti‐IFNAR1 antibody (anifrolumab), in a patient with STING‐associated vasculopathy with onset in infancy (SAVI) who had vasculitic ulcers and systemic inflammation refractory to Janus kinase inhibition (JAKi ...
Sara Alehashemi   +13 more
wiley   +1 more source

Clinical factors associated with pneumocystis pneumonia despite its primary prophylaxis: When to stop prophylaxis?

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Although previous studies show that primary prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is effective in patients with rheumatic diseases receiving immunosuppressive treatment, there is limited evidence regarding the optimal timing for prophylaxis withdrawal.
Ju Yeon Kim   +5 more
wiley   +1 more source

Expert perspective: How, When, and Why to Potentially Stop Anti‐resorptive Drugs in Osteoporosis

open access: yesArthritis &Rheumatology, Accepted Article.
Osteoporosis is a chronic disease and anti‐resorptive treatments are often continued for many years. Despite their established efficacy in reducing fracture risk, the most commonly used anti‐resorptive treatments bisphosphonates and denosumab have short and longer term risks that, coupled with their benefits and other unique characteristics, influence ...
Giovanni Adami, Kenneth G Saag
wiley   +1 more source

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