Results 31 to 40 of about 4,951,297 (306)
Macaque's Cortical Functional Connectivity Dynamics at the Onset of Propofol-Induced Anesthesia [PDF]
arXiv, 2021 Propofol, when administered for general anesthesia, induces oscillatory dynamic brain states that are thought to underlie the drug's pharmacological effects. Despite the elucidation of propofol's mechanisms of action at the molecular level, its effects on neural circuits and overall cortical functioning, which eventually lead to unconsciousness, are ...
arxiv
Anesthetic salts used in dentistry: a literature review
Journal Of Oral Investigations, 2017 Local anesthetics allow a better and suitable control of pain in patients that submit to dental treatments. The pharmacology of local anesthetics is too complex, therefore it is important to know how to select the correct drug to each procedure to be ...
Guilherme Klein Parise +2 more
doaj +1 more source
Progress of Drug Controlled Release Systems for Local Anesthesia
Xiehe Yixue Zazhi, 2022 Reducing the drug administration times and prolonging the postoperative analgesia duration are important requirements of clinical local anesthesia. However, both local anesthetics currently used in the clinic and potentially new anesthetic drugs such as ...
LONG Kai, CAO Pei, JI Tianjiao
doaj +1 more source
Common anesthetic molecules prefer to partition in liquid disorder phase domain in a composite multicomponent membrane [PDF]
Phys. Rev. E 98, 012409 (2018), 2018 Despite a vast clinical application of anesthetics, the molecular level of understanding of general anesthesia is far from our reach. Using atomistic molecular dynamics simulation, we study the effects of common anesthetics: ethanol, chloroform and methanol in the fully hydrated symmetric multicomponent lipid bilayer membrane comprising of an ...
arxiv +1 more source
True Allergy to Amide Local Anesthetics: A Review and Case Presentation.
Anesthesia Progress, 2018 Adverse reactions to local anesthetics are usually a reaction to epinephrine, vasovagal syncope, or overdose toxicity. Allergic reactions to local anesthetics are often attributed to additives such as metabisulfite or methylparaben.
Babak Bina +4 more
semanticscholar +1 more source
THE PHARMACOLOGY OF THE LOCAL ANESTHETICS [PDF]
Journal of the American Medical Association, 1919 Acute intoxication in man from the use of the local anesthetics is far more common than is indicated by the number of recorded cases. We undertook to investigate the causes of such intoxication, and sought to find means of avoiding it, or combating it when it arises.
Robert A. Hatcher, Cary Eggleston
openaire +2 more sources
Lipid Emulsion in the Successful Resuscitation of Local Anesthetic Toxicity after Ankle Block [PDF]
Korean Journal of Critical Care Medicine, 2014 Unexpected occurrence of local anesthetic toxicity is not rare and can cause fatal complications that do not respond to any known drug of intervention.
Sang Hee Park +5 more
doaj +1 more source
Pain Research and Treatment, 2018 Objective Peripheral nerve blocks for postoperative analgesia have improved block success, but analgesia efficacy has been limited by the short duration of traditional local anesthetics.
M. Kendall +2 more
semanticscholar +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source