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Advances in the use of local anesthetic extended-release systems in pain management
Drug DeliveryPain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management.
Yulu Chen +6 more
doaj +1 more source
Liquid general anesthetics lower critical temperatures in plasma membrane vesicles [PDF]
, 2013 A large and diverse array of small hydrophobic molecules induce general anesthesia. Their efficacy as anesthetics has been shown to correlate both with their affinity for a hydrophobic environment and with their potency in inhibiting certain ligand gated ion channels.
arxiv +1 more source
Membrane Nanodomains Homeostasis During Propofol Anesthesia as Function of Dosage and Temperature [PDF]
, 2020 Some anesthetics bind and potentiate gamma-aminobutyric-acid-type receptors, but no universal mechanism for general anesthesia is known. Furthermore, often encountered complications such as anesthesia induced amnesia are not understood. General anesthetics are hydrophobic molecules easily dissolving into lipid bilayers.
arxiv +1 more source
Adjuvants to local anesthetics: Current understanding and future trends
World Journal of Clinical Cases, 2017 Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system.
A. Swain +3 more
semanticscholar +1 more source
Molecular Oncology, Volume 19, Issue 5, Page 1371-1385, May 2025.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
Paresthesia in dentistry: The ignored neurotoxicity of local anesthetics
Heliyon, 2023 Local anesthetics are frequently used by dentists to relieve localized discomfort of the patient and improve treatment conditions. The risk of paresthesia after local anesthesia is frequently encountered in dental clinics.
Yong-zhen Tan +4 more
doaj
Basophil activation test in the diagnosis of allergic reactions to local anesthetics
Медицинский вестник Юга России, 2022 Objective: to evaluate the detection of in vitro hypersensitivity to local anesthesia drugs by fl ow cytometry.Materials and methods: in the test of activation of basophils, the determination of the hypersensitivity reaction to local anesthetics of ...
O. N. Chibisova +2 more
doaj +1 more source
Local anesthetics and their adjuncts [PDF]
Pediatric Anesthesia, 2011 SummaryLocal anesthetics (LA) block propagation of impulses along nerve fibers by inactivation of voltage‐gated sodium channels, which initiate action potentials (1). They act on the cytosolic side of phospholipid membranes. Two main chemical compounds are used, amino esters and amino amides. Amino esters are degraded by pseudocholinesterases in plasma.
openaire +3 more sources
Local anesthetics for brain tumor resection: current perspectives
Local and Regional Anesthesia, 2018 This review summarizes the added value of local anesthetics in patients undergoing craniotomy for brain tumor resection, which is a procedure that is carried out frequently in neurosurgical practice.
J. Potters, M. Klimek
semanticscholar +1 more source
Molecular Oncology, Volume 19, Issue 5, Page 1299-1309, May 2025.Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen +6 more
wiley +1 more source