Results 21 to 30 of about 66,697 (246)

Ketamine infusion as a sedative-analgesic in severe ARDS (KISS)

Journal of Community Hospital Internal Medicine Perspectives, 2021
Rationale Ketamine has been used as a sedative analgesic in trauma setting, but data regarding its efficacy and safety is lacking in severe ARDS.
Ramakanth Pata, Pagali Sandeep, Htun Min Aung, Meet J Patel, Tsering Dolkar, Nway Nway, Kosuru Bhanu, Abolfazl Ahmady, Roudabeh Kiani, Ramaiah Swaroop, Frances Schmidt, Danilo Enriquez   +11 more
doaj   +1 more source

Linalool induces relaxation of the mantle of golden apple snail (Pomacea canaliculata)

Anais da Academia Brasileira de Ciências, 2021
The objective of this study was to evaluate the possible relaxing effect of essential oils (EOs) (Aloysia triphylla and Lippia alba) and phytochemicals (citral and linalool) in the gastropod Pomacea canaliculata.
ADRIANE E. BIANCHINI, SHARINE N. DESCOVI, BERTA M. HEINZMANN, BERNARDO BALDISSEROTTO   +3 more
doaj   +1 more source

PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes

ADMET and DMPK, 2019
One of the primary objectives of physiologically based pharmacokinetics (PBPK) is the prediction of a drug’s pharmacokinetics just from knowledge of its physicochemical structure.
David G. Levitt
doaj   +1 more source

Can scleroderma be induced by anesthetics? Case report

Medycyna Pracy, 2016
Occupational exposure to solvents is consistently associated with the risk of systemic sclerosis. We pose the question of whether the occupational exposure to anesthetics may favor the occurrence of this disease.
Nicola Magnavita
doaj   +1 more source

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

The effects of anesthesia methods and anesthetics on postoperative delirium in the elderly patients: A systematic review and network meta-analysis

Frontiers in Aging Neuroscience, 2022
Study objectivePostoperative delirium (POD) is one of the serious postoperative complications in elderly patients, which is always related to long-term mortality. Anesthesia is often considered a risk factor for POD.
Xuhui Zhuang, Yuewen He, Yurui Liu, Jingjing Li, Jingjing Li, Wuhua Ma   +5 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Quantifying heterogeneity in an animal model of acute respiratory distress syndrome, a comparison of inspired sinewave technique to computed tomography

Scientific Reports
The inspired sinewave technique (IST) is a non-invasive method to measure lung heterogeneity indices (including both uneven ventilation and perfusion or heterogeneity), which reveal multiple conditions of the lung and lung injury.
Minh C. Tran, Douglas C. Crockett, Tu K. Tran, Phi A. Phan, Formenti Federico, Richard Bruce, Gaetano Perchiazzi, Stephen J. Payne, Andrew D. Farmery   +8 more
doaj   +1 more source

Detection of Occult Erythrocytic Membrane Damages upon Pharmacological Exposures

Общая реаниматология, 2007
Blood administration of pharmaceuticals may cause occult effects of these agents on erythrocytic membranes. These effects may damage and cause additional membrane defects, but may strengthen.
P. Yu. Alekseyeva, V. V Moroz, U. A. Bliznyuk, V. M. Yelagina, G. R. Kaziyev, V. Yu. Vasilyev, A. M. Chernysh, M. S. Bogushevich   +7 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source