Results 61 to 70 of about 310,289 (342)

The free energy of biomembrane and nerve excitation and the role of anesthetics

, 2018
In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference ...
Heimburg, Thomas, Jackson, Andrew D., Music, Tea, Wang, Tian   +3 more
core   +1 more source

High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]

, 2018
BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E., Dai, Jennifer B., Daigle, Renee, Forman, Stuart A., Halpin, Elizabeth S., Jounaidi, Youssef, Marte-Oquendo, Francisco, Porco, John A., Schaus, Scott E., Trilles, Richard, Xu, Wenqing, Yang, Xiaoxuan, Yu, Buwei   +12 more
core   +1 more source

Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer’s disease (Review)

Molecular Medicine Reports, 2015
The incidence of Alzheimer’s disease (AD) in individuals >65 years of age is 13% and ~66 million individuals in this age group undergo surgery annually under anesthesia.
Jue Jiang, Hong Jiang
semanticscholar   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Influence of the Anesthetic Technique on Circulating Extracellular Vesicles in Bladder Cancer Patients Undergoing Radical Cystectomy: A Prospective, Randomized Trial

Cells, 2023
Anesthetics have been shown to alter tumor progression and seem to influence surgical cancer outcome. Circulating extracellular vesicles as mediators of intercellular communication are involved in cancer progression and may be influenced by anesthetics ...
Luisa Gluth, Crista Ochsenfarth, Phuong Nam Viet Pham, Jan M. Wischermann, Thomas Komanek, Florian Roghmann, Ulrich H. Frey   +6 more
doaj   +1 more source

Fusion of secretory vesicles isolated from rat liver [PDF]

, 1978
Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy.
A. Amsterdam, A. Ichikawa, A. Lernmark, A.R. Poole, B. Hellman, B. Rose, C. Miller, C. Schudt, C. Schudt, C.M. Croge, D. Banerjee, D. Branton, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, E.K. Matthews, E.L. Pesanti, F. Malaisse-Lagae, G. Dahl, G. Dahl, G. Dahl, G. Poste, G. Virgilis De, G.M. Grodsky, G.R. Lawford, Gerhard Dahl, H. Schachter, J. Stadler, J.H. Ehrenreich, J.J.M. Bergeron, J.L. Mongar, J.S. Hong, L. Keay, L. Winquist, L.E. Hokin, M. Gratzl, M. Gratzl, M. Gratzl, M. Gratzl, M. Raiteri, M. Redman, M. Reporter, M.G. Farquar, Manfred Gratzl, N.A. Thorn, O. Stein, O.H. Lowry, P. Röhlich, P. Seeman, Q.F. Ahkong, R. Dipolo, R. Ekholm, R. Llinás, R. Miledi, R.C. Baker, R.D. Andrew, R.M. Case, R.P. Rubin, S.J. Burwen, T. Kanno, T. Maeda, T.Ch. Normann, W. Berger, W. Breisblatt, W. Breisblatt, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, Y. Marchand Le   +75 more
core   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Biochemical parameters of silver catfish (Rhamdia quelen) after transport with eugenol or essential oil of Lippia alba added to the water [PDF]

, 2017
The transport of live fish is a routine practice in aquaculture and constitutes a considerable source of stress to the animals. The addition of anesthetic to the water used for fish transport can prevent or mitigate the deleterious effects of transport ...
A. G. Becker, ALMROTH B.C., AZAMBUJA C.R., B. Baldisserotto, B. M. Heinzmann, BALDISSEROTTO B., BECKER A.G., BECKER A.G., BENOVIT S.C., BLENAU W., BRADFORD M.M., BUEGE J.A., C. C. Menezes, C. C. Zeppenfeld, C. Toni, COOKE S.J., CUNHA M.A., CUNHA M.A., DUBOIS M., ELLMAN G.L., ELLMAN G.L., GONÇALVES A.F.N., GOYAL A.K., HABIG W.H., HARROWER J.R., HUDETZ A.G., INOUE L.A.K.A., INOUE L.A.K.A., J. Salbego, LEUNG L.S., LINTERN M.C., LOWRY O.H., LÓPEZ M.D., MATÉS J.M., MAZZANTI L., MOMMSEN T.P., PANKHURST N.W., PARODI T.V., ROSS L.G., ROUBACH R., SALBEGO J., SALBEGO J., TONI C., UNGVARI Z., V. L. Loro, VALE T.G., VALE T.G., VILLARES JUNIOR G.A., YAN L.J., YONAR M.E., ZAHL I.H.   +50 more
core   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Knowledge and experience regarding perioperative anaphylaxis among anesthesiologists in Istanbul

AIMS Allergy and Immunology, 2017
Anesthesiologists are among the physicians with the highest probability of encountering cases with anaphylaxis. Therefore, they should be familiar with recent developments in anaphylaxis diagnosis and treatment.
Gulben Yakarıca Ergen, Huseyin Erdogan, Filiz Dilek Sirinoğlu, Sibel Oba, Feyzullah Cetinkaya   +4 more
doaj   +1 more source