Results 131 to 140 of about 10,428 (253)

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer

The Prostate, Volume 86, Issue 10, Page 1103-1114, July 2026.
ABSTRACT Background The management of intermediate‐risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. Methods We performed multi‐omic
William Lautert‐Dutra, Camila M. Melo, Luiz P. Chaves, Francisco C. Souza, Vida Talebian, Cheryl Crozier, Mary Anne Quintayo, Linda Liao, Dan Dion, Fabiano P. Saggioro, Felipe S. Avante, Rodolfo B. dos Reis, Jeremy A. Squire, Jane Bayani   +13 more
wiley   +1 more source

Sperm Sexing in Selected Animals and Humans: Methods, Applications, and Future Prospects

Andrology, Volume 14, Issue 5, Page 1089-1101, July 2026.
ABSTRACT Background Sperm sexing is a technique that enables the selection of offspring sex by sorting spermatozoa based on their sex chromosomes. This technology has gained increasing attention due to its potential applications in both animal breeding and human‐assisted reproduction.
Domrazek Kinga, Jurka Piotr
wiley   +1 more source

Exploring the increasing aneuploidy stress effects on embryo morphokinetic development: non-linear and stage-specific disruption in developmental timing. [PDF]

J Assist Reprod Genet
Roman IC, Coull G, Michielsen A, Nugent A, Carty H, Wale P, Gardner DK, Zăhan M.   +7 more
europepmc   +1 more source

Whole Exome Sequencing for Romanian Patients With Neurodevelopmental Disorders Through an International Collaboration

Clinical Genetics, Volume 110, Issue 1, Page 46-63, July 2026.
Whole exome sequencing for Romanian patients with neurodevelopmental disorders through an international collaboration—this study has provided a 50% diagnostic yield for patients with NDDs (27 positive results from 54 patients), supporting the implementation of a WES analysis that can identify SNVs, small INDELs, CNVs, and mitochondrial variants ...
Alexandru Caramizaru, Cristina Durac, Andreea Dumitrescu, Alexandru Calota‐Dobrescu, Alix de Becdelièvre, Marina Konyukh, Denise Cassandrini, Hane Lee, Go Hun Seo, Seung Woo Ryu, Mihai Cucu, Iuliana Manuela Dragomir, Andreea Catana, Homa Tajsharghi, Edoardo Malfatti, Florin Burada, Amelia Dobrescu   +16 more
wiley   +1 more source

Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss

Equine Veterinary Journal, Volume 58, Issue 4, Page 970-980, July 2026.
Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez, Alejandro de la Fuente, Kazuki Takahashi, Hugo Monteiro, Mauricio Mendes, Stuart Meyers, Pouya Dini   +6 more
wiley   +1 more source

Aneuploidy [PDF]

, 2019
openaire   +1 more source

Misdiagnosis of different types of aneuploidy in preimplantation genetic testing (PGT): a systematic review and meta-analysis. [PDF]

Arch Gynecol Obstet
Jiang W, Hu Z, Han Y, Shi J, Chen K, Lian Y, Li W, Hao P, Zhou Z, Wu Z, Li Y, Wu X, Li M, Deng L, Zheng H, Bi Z, Ding L, Pan X, Ma R, Tang Z, Mu J, Xie X, Li Y, Yan J.   +23 more
europepmc   +1 more source

Copy Number Analysis in Congenital Nevi: Concordance and Diagnostic Limitations of aCGH, sWGS, and Methylation Sequencing

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
Distinguishing proliferative nodules from melanoma in congenital melanocytic nevi remains challenging. While aCGH, sWGS, and methylation sequencing show high concordance for broad CNAs, higher‐resolution methods detect additional focal alterations that can lead to discordant classifications.
Anton Karelin, Ines B. Brecht, Michaela Pogoda, German Demidov, Michael Abele, Dominik T. Schneider, Daniel Aldea, Heather C. Etchevers, Susana Puig, Matthias Hahn, Christopher Schroeder, Stephan Forchhammer, on behalf of the MELCAYA consortium   +12 more
wiley   +1 more source

NIPT detects occult maternal malignancies via cfDNA aberration profiling: a case report. [PDF]

Front Med (Lausanne)
Wu L, Wang X, An J, Liu Y, Bai R, Wang J, Zhang W.   +6 more
europepmc   +1 more source

Efficacy and immunogenic effects of Tumor Treating Fields (TTFields) in preclinical models of pancreatic ductal adenocarcinoma, with and without gemcitabine/nab‐paclitaxel

International Journal of Cancer, Volume 158, Issue 12, Page 3091-3100, 15 June 2026.
What's new? Adaptive immune responses are typically limited in pancreatic ductal adenocarcinoma, resulting in minimal efficacy of immune checkpoint inhibitors. Tumor Treating Fields (TTFields) therapy, which uses low‐intensity intermediate‐frequency electric fields to disrupt cancer cell processes, has been approved for certain cancers.
Tal Kan, Tharwat Haj Khalil, Yiftah Barsheshet, Tali Voloshin, Lilach Koren, Bella Koltun, Cfir David, Kerem Wainer‐Katsir, Avital Vorontsova, Boris Brant, Simona Zisman‐Rozen, Hila M. Ene, Roni Frechtel‐Gerzi, Shay Cahal, Anat Klein‐Goldberg, Lena Lifshitz, Efrat Zemer Tov, Mai Shai, Adi Haber, Moshe Giladi, Uri Weinberg, Yoram Palti   +21 more
wiley   +1 more source