Results 91 to 100 of about 50,865 (308)

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Embryo aneuploidy and ivf outcomes in patients with different spermatozoa aneuploidy rates

Гинекология, 2013
Our goal was to study the 13, 18, 21, X, Y chromosomes aneuploidy rate in the embryos of the couples with different spermatozoa aneuploidy rate.In prospective cohort study 56 infertile couples were divided into 3 groups by the spermatozoa aneuploidy rate
S A Sokur, N V Dolgushina, Zh I Glinkina, A G Gorshkova, E A Kalinina   +4 more
doaj  

Aneuploidy in Early Miscarriage and its Related Factors

Chinese Medical Journal, 2015
Background: Genetic factors are the main cause of early miscarriage. This study aimed to investigate aneuploidy in spontaneous abortion by fluorescence in situ hybridization (FISH) using probes for 13, 16, 18, 21, 22, X and Y chromosomes.
Chan-Wei Jia, Li Wang, Yong-Lian Lan, Rui Song, Li-Yin Zhou, Lan Yu, Yang Yang, Yu Liang, Ying Li, Yan-Min Ma, Shu-Yu Wang   +10 more
doaj   +1 more source

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source

Clinician views and experiences of non‐invasive prenatal genetic screening tests in Australia

Australian and New Zealand Journal of Obstetrics and Gynaecology, Volume 62, Issue 6, Page 830-837, December 2022., 2022
Background Non‐invasive prenatal screening (NIPS) is being increasingly used by expectant parents. Much provision of this test in Australia is occurring in clinical settings where specialised genetic counselling is unavailable, such as general practice.
Shannon McKinn, Nasrin Javid, Ainsley J. Newson, Lucinda Freeman, Carissa Bonner, Antonia W. Shand, Natasha Nassar, Katy J.L. Bell   +7 more
wiley   +1 more source

Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaning

Neurobiology of Disease, 2009
Recently it has been suggested that the human brain contains aneuploid cells; however the nature and magnitude of neural aneuploidy in health and disease remain obscure. Here, we have monitored aneuploidy in the cerebral cortex of the normal, Alzheimer's
Ivan Y. Iourov, Svetlana G. Vorsanova, Thomas Liehr, Yuri B. Yurov   +3 more
doaj  

Machine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4

Frontiers in Bioscience-Landmark
Background: Aneuploidy is crucial yet under-explored in cancer pathogenesis. Specifically, the involvement of brain expressed X-linked gene 4 (BEX4) in microtubule formation has been identified as a potential aneuploidy mechanism ...
Aizhong Xu, Jianjun Liu, Li Tong, Tingting Shen, Songlin Xing, Yujie Xia, Bosen Zhang, Zihao Wu, Wenkang Yuan, Anhai Yu, Zijie Kan, Wenqi Yang, Chao Zhang, Chong Zhang   +13 more
doaj   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

International Journal of Cancer, EarlyView.
What's New? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita, Chiara Maria Mazzanti, Francesca Lessi, Caterina Marchiò, Cristian Scatena, Michele Menicagli, Matteo Ghilli, Manuela Roncella, Antonio Giuseppe Naccarato, Anna Sapino, Jacob Hochman, Mauro Pistello, Generoso Bevilacqua   +12 more
wiley   +1 more source

Preventing common hereditary disorders through time-separated twinning [PDF]

arXiv, 2013
Biomedical advances have led to a relaxation of natural selection in the human population in developed countries. In the absence of strong purifying selection, spontaneous and frequently deleterious mutations tend to accumulate in the human genome and gradually increase the genetic load; that is, the frequency of potentially lethal genes in the gene ...
arxiv  

Accuracy of ultrasound estimation of fetal weight in twin pregnancy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To determine the accuracy of formulas for estimation of fetal weight in twin pregnancy. Methods Inclusion criteria from the ESPRiT twin cohort were twin pregnancies that resulted in live‐born twins without congenital anomalies or twin‐twin transfusion syndrome, ultrasound examination within 3 days of delivery, birth weight (BW) > 500 
Patrick Dicker, Ronan Conroy, Fionnuala McAuliffe, Michael Geary, Sean Daly, John J. Morrison, Stephen Carroll, Fergal D. Malone, Fionnuala M. Breathnach   +8 more
wiley   +1 more source