Results 91 to 100 of about 93,321 (331)

The genetic basis of aneuploidy tolerance in wild yeast

eLife, 2020
Aneuploidy is highly detrimental during development yet common in cancers and pathogenic fungi – what gives rise to differences in aneuploidy tolerance remains unclear.
James Hose, Leah E Escalante, Katie J Clowers, H Auguste Dutcher, DeElegant Robinson, Venera Bouriakov, Joshua J Coon, Evgenia Shishkova, Audrey P Gasch   +8 more
doaj   +1 more source

ASPM Induces Radiotherapy Resistance by Disrupting Microtubule Stability Leading to Chromosome Malsegregation in Non‐Small Cell Lung Cancer

Exploration, EarlyView.
Abnormal spindle‐like microcephaly‐associated protein helps radiotherapy resistant cells to evade spindle checkpoint surveillance and complete cell division after irradiation through destruction of microtubule stability, with subsequent increases in chromosome mis‐segregation and deteriorating chromosomal stability during mitosis to promote ...
Tao Zhong, Ning Liu, Juan Wang, Songbo Xie, Lisheng Liu, Minglei Wang, Fei Wu, Xiaozheng Chen, Changyan Xiao, Xiaoxiao Gongye, Meng Wu, Liewei Wen, Jinming Yu, Dawei Chen   +13 more
wiley   +1 more source

DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes [PDF]

, 2012
There is some interest in how mammalian oocytes respond to different types of DNA damage because of the increasing expectation of fertility preservation in women undergoing chemotherapy.
Julie A. Merriman, Keith T Jones, Michael R. Volkert, Moira K. O'Bryan, Wai Shan Yuen   +4 more
core   +3 more sources

The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes

International Journal of Cancer, EarlyView.
What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville, Lisa J. Russell, Kay Padget, Akram Ghantous, Jessica Nordlund, Jill A. McKay   +5 more
wiley   +1 more source

Fluorescence in situ hybridisation study of micronuclei in C3A cells following exposure to ELF-magnetic fields [PDF]

, 2019
Human C3A cells were exposed to extremely low frequency (50 Hz) magnetic fields (ELF-MF's) up to 500 mu T. They were subjected to the micronucleus assay using a Fluorescence In Situ Hybridization (FISH) technique with an in-house pan-centromere probe. We
Antonissen, Roel, Baeyens, Ans, Maes, Annemarie, Verschaeve, Luc, Vral, Anne   +4 more
core   +1 more source

Machine-learning analysis reveals an important role for negative selection in shaping cancer aneuploidy landscapes

Genome Biology
Background Aneuploidy, an abnormal number of chromosomes within a cell, is a hallmark of cancer. Patterns of aneuploidy differ across cancers, yet are similar in cancers affecting closely related tissues.
Juman Jubran, Rachel Slutsky, Nir Rozenblum, Lior Rokach, Uri Ben-David, Esti Yeger-Lotem   +5 more
doaj   +1 more source

Accuracy of ultrasound estimation of fetal weight in twin pregnancy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To determine the accuracy of formulas for estimation of fetal weight in twin pregnancy. Methods Inclusion criteria from the ESPRiT twin cohort were twin pregnancies that resulted in live‐born twins without congenital anomalies or twin‐twin transfusion syndrome, ultrasound examination within 3 days of delivery, birth weight (BW) > 500 
Patrick Dicker, Ronan Conroy, Fionnuala McAuliffe, Michael Geary, Sean Daly, John J. Morrison, Stephen Carroll, Fergal D. Malone, Fionnuala M. Breathnach   +8 more
wiley   +1 more source

Scientific Opinion on Flavouring Group Evaluation 63, Revision 3 (FGE.63Rev3): aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th and 69th meetings) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids evaluated by EFSA in FGE.07Rev4 [PDF]

, 2017
Publisher ...
Binderup, Mona-Lise, Bolognesi, Claudia, Brimer, Leon, Castle, Laurence, Cravedi, Jean-Pierre, Crebelli, Riccardo, de Fátima Tavares Poças, Maria, EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), Engel, Karl-Heinz, Fowler , Paul, Franz, Roland, Grob, Konrad, Gürtler, Rainer, Husøy, Trine, Kovalkovičová, Natália, Kärenlampi, Sirpa, Marcon, Francesca, Marzin, Daniel, Mennes, Wim, Mosesso, Pasquale, Mulder, Gerard, Penninks, André, Rosaria Milana, Maria, Silano, Vittorio, Smith, Andrew, Sundh, Ulla Beckman, Tlustos, Christina, Wölfle , Detlef, Zorn, Holger, Zugravu, Corina-Aurelia   +29 more
core   +2 more sources

Complex interplay between p53 and chromosome stability

Molecular & Cellular Oncology, 2021
TP53-dependent cell cycle arrest has been proposed to limit the proliferation of aneuploid cells. We investigated the cellular response to aneuploidy in cell lines and organoid cultures and found that TP53 (also known as p53) is not activated following ...
Akshay Narkar, Blake A. Johnson, Rong Li
doaj   +1 more source

Urachal Villous Adenoma Coexistent With Urachal Carcinoma: A Case Report

IJU Case Reports, EarlyView.
ABSTRACT Introduction Urinary tract villous adenomas are uncommon, urachal villous adenomas being especially rare. While their malignant potential remains uncertain, villous adenomas may have malignant components. Here, we present a case of the coexistence of a urachal villous adenoma and urachal carcinoma. Case Presentation We report the case of an 86‐
Shotaro Hatano, Yousuke Shimizu, Hirotake Fujii, Koken Hayashi, Ken Maekawa, Yasuyuki Miyauchi, Takaki Sakurai, Kenji Mitsumori, Hiroyuki Onishi   +8 more
wiley   +1 more source