Results 11 to 20 of about 54,677 (265)
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
Nature Communications, 2017 Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope ...
Tohru Takaki +10 more
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mBio, 2017 Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in
F. Dumetz +17 more
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Neurobiology of Disease, 2009 Recently it has been suggested that the human brain contains aneuploid cells; however the nature and magnitude of neural aneuploidy in health and disease remain obscure. Here, we have monitored aneuploidy in the cerebral cortex of the normal, Alzheimer's
Ivan Y. Iourov +3 more
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Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut
Biology Open, 2021 Aneuploidy has been strongly linked to cancer development, and published evidence has suggested that aneuploidy can have an oncogenic or a tumor suppressor role depending on the tissue context.
Rita Brás +3 more
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Cold Spring Harbor Symposia on Quantitative Biology, 2010 Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosomes. This condition is associated with disease and death in all organisms in which it has been studied. We have characterized the effects of aneuploidy on yeast and primary mouse cells and found it to be detrimental at the cellular level.
Torres Mejia, Elen Raquel Sarabasti +3 more
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Molecular signatures of aneuploidy-driven adaptive evolution
Nature Communications, 2020 Aneuploidy (abnormal chromosome number) can enable rapid adaptation to stress conditions, but it also entails fitness costs from gene imbalance. Here, the authors experimentally evolve yeast while forcing maintenance of aneuploidy to identify the ...
Alaattin Kaya +8 more
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Selfish centromeres and the wastefulness of human reproduction.
PLoS Biology, 2022 Many human embryos die in utero owing to an excess or deficit of chromosomes, a phenomenon known as aneuploidy; this is largely a consequence of nondisjunction during maternal meiosis I.
Laurence D Hurst
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Chromosomal Instability, Aneuploidy, and Gene Mutations in Human Sporadic Colorectal Adenomas
Cellular Oncology, 2004 Whether in vivo specific gene mutations lead to chromosomal instability (CIN) and aneuploidy or viceversa is so far not proven. We hypothesized that aneuploidy among human sporadic colorectal adenomas and KRAS2 and APC mutations were not independent ...
Walter Giaretti +3 more
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Aneuploidy and confined chromosomal mosaicism in the developing human brain. [PDF]
PLoS ONE, 2007 BACKGROUND: Understanding the mechanisms underlying generation of neuronal variability and complexity remains the central challenge for neuroscience.
Yuri B Yurov +11 more
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PLoS Biology, 2019 Studying aneuploidy during organism development has strong limitations because chronic mitotic perturbations used to generate aneuploidy usually result in lethality.
Mihailo Mirkovic +4 more
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