Results 11 to 20 of about 93,321 (331)
Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast [PDF]
eLife, 2014 Aneuploidy causes severe developmental defects and is a near universal feature of tumor cells. Despite its profound effects, the cellular processes affected by aneuploidy are not well characterized. Here, we examined the consequences of aneuploidy on the
Amon, Angelika +6 more
core +4 more sources
Frontiers in Cell and Developmental Biology, 2022 Aneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa
Yun Peng, Yuxuan Song, Haitao Wang
doaj +1 more source
Frontiers in Immunology, 2022 Chromosome instability (CIN) and its major consequence, aneuploidy, are hallmarks of human cancers. In addition to imposing fitness costs on tumor cells through several cell-intrinsic mechanisms, CIN/aneuploidy also provokes an antitumor immune response.
Xiaohong Kuang, Jian Li
doaj +1 more source
Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer
Cells, 2021 Chromosomal instability is the process of mis-segregation for ongoing chromosomes, which leads to cells with an abnormal number of chromosomes, also known as an aneuploid state.
Laura J. Jilderda +2 more
doaj +1 more source
Causes, consequences and clinical significance of aneuploidy across melanoma subtypes
Frontiers in Oncology, 2022 Aneuploidy, the state of the cell in which the number of whole chromosomes or chromosome arms becomes imbalanced, has been recognized as playing a pivotal role in tumor evolution for over 100 years.
Eva R. Shteinman +20 more
doaj +1 more source
Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?
Stem Cells Translational Medicine, 2020 The demand for an efficient therapy for alopecia disease has fueled the hair research field in recent decades. However, despite significant improvements in the knowledge of key processes of hair follicle biology such as genesis and cycling, translation ...
Ana Rita Castro, Elsa Logarinho
doaj +1 more source
Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer [PDF]
Open Biology, 2020 Aneuploidy, an irregular number of chromosomes in cells, is a hallmark feature of cancer. Aneuploidy results from chromosomal instability (CIN) and occurs in almost 90% of all tumours.
Lin Zhou +2 more
doaj +1 more source
Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut
Biology Open, 2021 Aneuploidy has been strongly linked to cancer development, and published evidence has suggested that aneuploidy can have an oncogenic or a tumor suppressor role depending on the tissue context.
Rita Brás +3 more
doaj +1 more source
Aneuploidy: Tolerating Tolerance [PDF]
Current Biology, 2015 Individuals, and cells, vary in their ability to tolerate aneuploidy, an unbalanced chromosome complement. Tolerance mechanisms can be karyotype-specific or general. General tolerance mechanisms may allow cells to benefit from the phenotypic plasticity conferred by access to multiple aneuploid states.
Aimée M. Dudley, Gareth A. Cromie
openaire +3 more sources
Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]
, 2019 Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller +31 more
core +1 more source