Results 21 to 30 of about 420 (127)

Anti-rheumatoid Arthritis Mechanisms of Angelicae Pubescentis Radix

2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2019
Angelicase Pubescentis Radix (APR) has been used in the practices of traditional Chinese medicine (TCM) with anti-rheumatoid arthritis (RA) effects called “wind-dampness-dispelling and cold dispersing”. In TCM prescriptions and patient medicines, APR has been widely adopted against RA. Till now, the anti-rheumatoid mechanisms are still obscure. In this
Guang Zheng, Junping Zhan
core   +2 more sources

Pharmacological and Pharmacokinetic Insights Into Columbianadin: A Promising Natural Anti-Inflammatory Compound. [PDF]

Mediators Inflamm
Columbianadin (CBN), a dihydroangelic acid ester and a naturally occurring coumarin compound, is primarily derived from plants in the Apiaceae family, notably the traditional Chinese medicinal herb Angelica pubescens. Modern pharmacological research has revealed that CBN exhibits a broad spectrum of bioactivities, including neuroprotective, antitumor ...
Wang Y, Tang L, Miao J, Cheng S, Xu Y, Xie W.   +5 more
europepmc   +2 more sources

Immunomodulatory Mechanisms of Rehmanniae Radix Praeparata-Achyranthes Root-Chinese Angelica Root Combination in Nontraumatic Osteonecrosis of the Femoral Head: A Comprehensive Network Pharmacology and Molecular Docking Study Focusing on Immunological Pathways. [PDF]

Mediators Inflamm
Objective Nontraumatic osteonecrosis of the femoral head (NONFH) is a devastating condition characterised by immune dysregulation and sterile inflammation, which are increasingly acknowledged as central pathogenic mechanisms. This study aims to identify the core herbal combination for NONFH and systematically explore its immunomodulatory effects and ...
Li X, Ng L, Liu C, Qin L, Xiao P, Liu C, Liu Y, Zhang Q, Huang W, Zhou Y.   +9 more
europepmc   +2 more sources

Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions. [PDF]

CNS Neurosci Ther
This study elucidates the central role of transient receptor potential (TRP) channels in driving neuroinflammation across neurological disorders. Acting as critical molecular sensors on neurons and glial cells, TRP channels' activation initiates downstream pathways that promote the release of proinflammatory cytokines, a pathological mechanism in ...
Guo D, Cai M, Xian Y, Chen Y, Feng Y, Hu C, Zeng L, Shi L, Zhang S.   +8 more
europepmc   +2 more sources

Anti-Inflammatory Effect of Columbianetin on Lipopolysaccharide-Stimulated Human Peripheral Blood Mononuclear Cells

Mediators of Inflammation, 2018
Dysregulated inflammation is increasingly considered as the main cause of many diseases on which NOD1/NF-κB pathway plays an important role. Columbianetin (CBT) is derived from the root of the Chinese herb Radix Angelicae Pubescentis for treating ...
Junying Lu, Keyong Fang, Shiji Wang, Lingxin Xiong, Chao Zhang, Zhongmin Liu, Xuewa Guan, Ruipeng Zheng, Guoqiang Wang, Jingtong Zheng, Fang Wang   +10 more
doaj   +2 more sources

Daqinjiao Decoction Ameliorates CSVD via RXR-γ/PPAR-γ/VEGF-α Pathway: Insights From Transcriptome Sequencing and Network Pharmacology. [PDF]

J Cell Mol Med
ABSTRACT Daqinjiao decoction (DQJD), an ancient traditional Chinese medicine formula, is clinically used in the treatment of cerebral small vessel disease (CSVD). However, the underlying molecular mechanisms by which DQJD exerts its therapeutic effects on CSVD remain elusive.
Lv M, Yang X, Shi X, Cao S, Li W, Zhou M, Gou X, Huang Y.   +7 more
europepmc   +2 more sources

Anthelmintic activity of the crude extracts, fractions, and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo

Parasitology Research, 2010
A bioassay-guided fractionation was performed to evaluate the anthelmintic activity of the crude extract fractions and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo. Among four extracts (petroleum ether, ethyl acetate, acetone, and ethanol), only ethanol extract exhibited the best ...
Lu Yao, Kai-yu Wang, Yong-hua Du, Zhong-qiong Yin, Jin-lu Huang, Jia-bing Xie   +5 more
core   +3 more sources

Radix Angelicae pubescentis — Duhuo

, 2011
Anton Staudinger, Rudolf Bauer, Dieter Melchart, Pei-Gen Xiao, Hildebert Wagner   +4 more
core   +2 more sources

Determination of bioactive coumarins in Radix angelicae pubescentis by HPLC

Planta Medica, 2011
Y Cheng, W Yan, M Zhu
core   +2 more sources

Comparison of Pharmacokinetic Profiles of 14 Major Bioactive Components in Normal and Arthritic Model Rats after Oral Administration of Angelicae pubescentis Radix by UPLC-MS/MS. [PDF]

Evid Based Complement Alternat Med, 2022
An ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established to simultaneously determine 14 compounds of Angelicae pubescentis Radix (APR) in normal and arthritis rat plasma in which chloramphenicol and daidzein were used as the internal standards.
Hou A, Yu H, Wang S, Zhang J, Wang X, Zheng S, Yang L, Kuang H, Jiang H.   +8 more
europepmc   +3 more sources