Results 111 to 120 of about 577,014 (316)

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Revascularization after angiogenesis inhibition favors new sprouting over abandoned vessel reuse

, 2019
Inhibiting pathologic angiogenesis can halt disease progression, but such inhibition may offer only a temporary benefit, followed by tissue revascularization after treatment stoppage.
Lennikov, Anton, Jensen, Lasse,, Lennikov, Anton,, Mukwaya, Anthony,, Thangavelu, Muthukumar, Mirabelli, Pierfrancesco,, Jensen, Lasse, Thangavelu, Muthukumar,, Lagali, Neil, Mukwaya, Anthony, Peebo, Beatrice,, Mirabelli, Pierfrancesco, Peebo, Beatrice, Ntzouni, Maria,, Ntzouni, Maria, Lagali, Neil,   +15 more
core   +1 more source

Shed syndecan-2 inhibits angiogenesis [PDF]

, 2014
J.W. is supported by grants from Arthritis Research UK [grant number 19207]; G.D.R. is supported by Barts and the London School of Medicine and Dentistry; A.W. is supported by the British Heart Foundation [grant number FS/11/19/28761]; and S.N.
Whiteford, JR, Kay, E, Woodfin, A, De Rossi, G, Evans, AR, McKay, TR, Nourshargh, S   +6 more
core   +1 more source

Expression and purification of bioactive, low-endotoxin recombinant human vitronectin

BioTechniques, 2014
The secreted adhesive glycoprotein vitronectin (VTN) is a multifunctional component of plasma and the extracellular matrix. A high-yielding, inexpensive, low endotoxin source of bioactive recombinant human vitronectin (rhVTN) is highly desirable for in ...
Michael M. Halford, Yi-Chao He, Steven A. Stacker   +2 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

The interaction of Notch signalling, haemodynamic flow and angiogenesis in Von Hippel-Lindau mutant zebrafish. [PDF]

, 2013
Introduction: There is increasing evidence that the endothelium is able to transduce circulatory force into signals which influence angiogenic behaviour.
Watson, Oliver
core  

Selective IKK2 inhibitor IMD0354 disrupts NF-kappa B signaling to suppress corneal inflammation and angiogenesis

, 2018
Corneal neovascularization is a sight-threatening condition caused by angiogenesis in the normally avascular cornea. Neovascularization of the cornea is often associated with an inflammatory response, thus targeting VEGF-A alone yields only a limited ...
Pierfrancesco Mirabelli, Thangavelu, Muthukumar, Mieszko Lachota, Lasse Jensen, Schaupper, Mira,, Lagali, Neil, Lachota, Mieszko,, Ali, Zaheer, Ali, Zaheer,, Lachota, Mieszko, Anton Lennikov, Mirabelli, Pierfrancesco, Schaupper, Mira, Lennikov, Anton, Jensen, Lasse,, Neil Lagali, Lennikov, Anton,, Mukwaya, Anthony,, Mirabelli, Pierfrancesco,, Anthony Mukwaya, Jensen, Lasse, Zaheer Ali, Thangavelu, Muthukumar,, Mukwaya, Anthony, Muthukumar Thangavelu, Mira Schaupper, Lagali, Neil,   +26 more
core   +1 more source

Cripto-1 and Cripto-3 differential expression pattern in human placenta, umbilical cord and fetal tissues suggests new functions for these proteins

Scientific Reports
Cripto-1 (CR1) is an oncofetal protein involved in EGF/TGFβ signal transduction, with important functions in development, stem cell biology and cancer. Its homolog, Cripto-3 (CR3), is almost identical, with the exception of six (out of 188) amino acids ...
Josune García-Sanmartín, Judit Narro-Íñiguez, María José Puente, Frank Cuttitta, Alfredo Martínez   +4 more
doaj   +1 more source

Inhibition of Tumor Growth and Angiogenesis by Soluble EphB4

Neoplasia: An International Journal for Oncology Research, 2004
EphB receptors and their ephrinB ligands play a key role in the formation of a regular vascular system. Recent studies have also shown the involvement of Eph/ephrin interactions in malignant tumor progression and angiogenesis.
Georg Martiny-Baron, Thomas Korff, Florence Schaffner, Norbert Esser, Stefan Eggstein, Dieter Marme, Hellmut G. Augustin   +6 more
doaj   +1 more source

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source