Results 11 to 20 of about 373,608 (350)

Editorial: Angiogenesis and Angiogenesis Inhibitors in Oral Cancer [PDF]

Frontiers in Oral Health, 2021
Non peer ...
Abdelhakim Salem, Abdelhakim Salem, Elin Hadler-Olsen, Elin Hadler-Olsen, Ahmed Al-Samadi, Ahmed Al-Samadi   +5 more
doaj   +4 more sources

An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model

Scientific Reports, 2021
In order to identify more effective therapy for recalcitrant osteosarcoma, we evaluated the efficacy of an mTOR-VEGFR inhibitor combination on tumor growth in a unique osteosarcoma patient-derived orthotopic xenograft (PDOX) mouse model derived from the ...
Hiromichi Oshiro, Yasunori Tome, Kentaro Miyake, Takashi Higuchi, Norihiko Sugisawa, Fuminori Kanaya, Kotaro Nishida, Robert M. Hoffman   +7 more
doaj   +1 more source

Body Composition to Define Prognosis of Cancers Treated by Anti-Angiogenic Drugs

Diagnostics, 2023
Background: Body composition could help to better define the prognosis of cancers treated with anti-angiogenics. The aim of this study is to evaluate the prognostic value of 3D and 2D anthropometric parameters in patients given anti-angiogenic treatments.
Pierre Decazes, Samy Ammari, Antoine De Prévia, Léo Mottay, Littisha Lawrance, Younes Belkouchi, Baya Benatsou, Laurence Albiges, Corinne Balleyguier, Pierre Vera, Nathalie Lassau   +10 more
doaj   +1 more source

Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report

Frontiers in Oncology, 2021
A novel SS18-POU5F1 fusion gene was recently reported in soft tissue sarcoma occurring in three adolescent and young adult patients. Herein, we firstly reported the treatment response of SS18-POU5F1 sarcoma to immune checkpoint inhibitor, angiogenesis ...
Zengjun Liu, Zengjun Liu, Hongtu Yuan, Mingyong Han   +3 more
doaj   +1 more source

A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression

Frontiers in Pharmacology, 2020
Angiogenesis dysregulation contributes to inflammation, infections, immune disorders, and carcinogenesis. Bromodomain-containing protein 4 (BRD4) is an epigenetic reader that recognizes histone proteins and acts as a transcriptional regulator to trigger ...
Zijun Zhou, Xiaoming Li, Zhiqing Liu, Lixun Huang, Yuying Yao, Liuyou Li, Jian Chen, Rongxin Zhang, Rongxin Zhang, Jia Zhou, Lijing Wang, Lijing Wang, Qian-Qian Zhang, Qian-Qian Zhang   +13 more
doaj   +1 more source

Comparative characteristics of the outcomes of the use of multidirectional intravitreal pharmacotherapy in the treatment of diabetic macular edema

Офтальмохирургия, 2021
Purpose. To conduct a comparative analysis of the effectiveness of intravitreal injection of dexamethasone-containing implant and aflibercept in macular edema in patients with diabetes mellitus.Material and methods.
M. M. Bikbov, K. I. Kudoyarova, R. M. Zainullin, T. R. Gilmanshin   +3 more
doaj   +1 more source

Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]

, 2020
Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I, Tabish, Tanveer A, Whatmore, Jacqueline L, Zhang, Shaowei   +3 more
core   +2 more sources

Angiogenesis Inhibitors as Anti-Cancer Therapy Following Renal Transplantation: A Case Report and Review of the Literature

Current Oncology, 2021
Solid organ transplant recipients on long-term immunosuppressive medication are at increased risk of developing malignancy, and treatment of advanced cancers with angiogenesis inhibitors in this context has not been widely studied.
Lawrence Kasherman, Jeffrey Doi, Katherine Karakasis, Jeffrey Schiff, Abhijat Kitchlu, Stephanie Lheureux, Amit M. Oza   +6 more
doaj   +1 more source

Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness

Frontiers in Cell and Developmental Biology, 2021
Angiogenesis is an essential process during development. Abnormal angiogenesis also contributes to many disease conditions such as tumor and retinal diseases.
Xiao Jiang, Jiandong Hu, Ziru Wu, Sarah Trusso Cafarello, Mario Di Matteo, Ying Shen, Xue Dong, Xue Dong, Heike Adler, Massimiliano Mazzone, Carmen Ruiz de Almodovar, Xiaohong Wang, Xiaohong Wang   +12 more
doaj   +1 more source

Efficacy and safety of angiogenesis inhibitors in advanced gastric cancer: a systematic review and meta-analysis

Journal of Hematology & Oncology, 2016
Monoclonal antibodies and small molecule tyrosine kinase inhibitors (TKIs) directed against the vascular endothelial growth factor (VEGF) or its receptors have been investigated in several studies for the treatment of advanced gastric cancer (GC). In the
Jing Yu, Yue Zhang, Lai-Han Leung, Lian Liu, Fan Yang, Xiaojun Yao   +5 more
doaj   +1 more source