Results 21 to 30 of about 209,193 (336)

Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness

Frontiers in Cell and Developmental Biology, 2021
Angiogenesis is an essential process during development. Abnormal angiogenesis also contributes to many disease conditions such as tumor and retinal diseases.
Xiao Jiang, Jiandong Hu, Ziru Wu, Sarah Trusso Cafarello, Mario Di Matteo, Ying Shen, Xue Dong, Xue Dong, Heike Adler, Massimiliano Mazzone, Carmen Ruiz de Almodovar, Xiaohong Wang, Xiaohong Wang   +12 more
doaj   +1 more source

Efficacy and safety of angiogenesis inhibitors in advanced gastric cancer: a systematic review and meta-analysis

Journal of Hematology & Oncology, 2016
Monoclonal antibodies and small molecule tyrosine kinase inhibitors (TKIs) directed against the vascular endothelial growth factor (VEGF) or its receptors have been investigated in several studies for the treatment of advanced gastric cancer (GC). In the
Jing Yu, Yue Zhang, Lai-Han Leung, Lian Liu, Fan Yang, Xiaojun Yao   +5 more
doaj   +1 more source

Inhibition of Pathological Retinal Neovascularization by a Small Peptide Derived from Human Tissue-Type Plasminogen Kringle 2

Frontiers in Pharmacology, 2020
Retinal neovascularization is a hallmark pathological process of numerous ocular diseases which comprise the most common causes of blindness and affect millions of people from infants to the elderly.
Qian Sun, Qian Sun, Qian Sun, Yinchen Shen, Yinchen Shen, Yinchen Shen, Li Su, Li Su, Li Su, Xun Xu, Xun Xu, Xun Xu   +11 more
doaj   +1 more source

A case of retinal tear associated with use of sorafenib

Frontiers in Oncology, 2014
Inhibition of angiogenesis is a target in the treatment of a variety of malignancies. Sorafenib is an oral inhibitor of multiple tyrosine kinases involved in tumor angiogenesis.
Kelly M. Gaertner, Stephen H. Caldwell, Osama eRahma   +2 more
doaj   +1 more source

Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

eLife, 2021
Disorders of the transparent cornea affect millions of people worldwide. However, how to maintain and/or regenerate this organ remains unclear. Here, we show that Rela (encoding a canonical NF-κB subunit) ablation in K14+ corneal epithelial stem cells ...
Qian Yu, Soma Biswas, Gang Ma, Peiquan Zhao, Baojie Li, Jing Li   +5 more
doaj   +1 more source

Hopf bifurcation of a free boundary problem modeling tumor growth with angiogenesis and two time delays [PDF]

, 2021
This paper concerns a free boundary problem modeling tumor growth with angiogenesis and two time delays. The two delays represent the time taken for cells to undergo mitosis and modify the rate of cell loss because of apoptosis, respectively. We study the stability of stationary solutions and find that Hopf bifurcation occurs under some conditions ...
arxiv   +1 more source

Сlinical, functional and morphological results of diabetic macular edema antiangiogenic treatment in patients with diabetes mellitus type two

Oftalʹmologiâ, 2014
Purpose: To evaluate of retinal morphology and function progress in patients with diabetes type 2 and DME consistent with the level of pathogenetic factor in tear fluid.Methods: The progress of visual acuity, retinal thickness and photosensitivity after ...
L. K. Moshetova, I. V. Vorobieva, E. V. Parfenova, D. A. Merkushenkova, P. I. Makarevich, V. I. Alekhnovich   +5 more
doaj   +3 more sources

Global Dormancy of Metastases Due to Systemic Inhibition of Angiogenesis [PDF]

PLoS ONE 9(1): e84249, 2014
Autopsy studies of adults dying of non-cancer causes have shown that virtually all of us possess occult, cancerous lesions. This suggests that, for most individuals, cancer will become dormant and not progress, while only in some will it become symptomatic disease.
arxiv   +1 more source

Cardiovascular toxicity profiles of immune checkpoint inhibitors with or without angiogenesis inhibitors: a real-world pharmacovigilance analysis based on the FAERS database from 2014 to 2022

Frontiers in Immunology, 2023
BackgroundImmune checkpoint inhibitors (ICIs) combined with angiogenesis inhibitors (AGIs) have become increasingly available for multiple types of cancers, although the cardiovascular safety profiles of this combination therapy in real-world settings ...
Yanfeng Wang, Chanjuan Cui, Lei Deng, Lin Wang, Xiayang Ren   +4 more
doaj   +1 more source

Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner

Pharmaceutics, 2022
BTK inhibitor (BTKi) Ibrutinib carries an increased bleeding risk compared to more selective BTKis Acalabrutinib and Zanubrutinib, however, its impact on vascular endothelium remains unknown.
Jia Liu, Zhuojun Liu, Jing Zhang, Xiaofang Chen, Junge Chen, Linlin Sui, Jian Yu   +6 more
doaj   +1 more source