Results 11 to 20 of about 182,387 (331)
Endogenous inhibitors of angiogenesis [PDF]
Journal of Cell Science, 2001 In the course of embryonic development, during some normal physiological processes in the adult, such as the female reproductive cycle, and also in a variety of pathologies, including tumour growth, new blood vessels develop from the pre-existing vascular network through endothelial cell sprouting,
Christiana Ruhrberg
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Cardiotoxic effects of angiogenesis inhibitors. [PDF]
Clin Sci (Lond), 2021 Abstract The development of new therapies for cancer has led to dramatic improvements in survivorship. Angiogenesis inhibitors represent one such advancement, revolutionising treatment for a wide range of malignancies. However, these drugs are associated with cardiovascular toxicities which can impact optimal cancer treatment in the ...
Dobbin SJH +4 more
europepmc +6 more sources
Thalidomide is an inhibitor of angiogenesis. [PDF]
Proceedings of the National Academy of Sciences, 1994 Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered thalidomide is an inhibitor of angiogenesis induced by basic fibroblast growth factor in a rabbit cornea micropocket assay.
Michael S. Loughnan +3 more
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Angiogenesis Inhibitors in NSCLC. [PDF]
Int J Mol Sci, 2017 Angiogenesis is a complex biological process that plays a relevant role in sustaining the microenvironment, growth, and metastatic potential of several tumors, including non-small cell lung cancer (NSCLC). Bevacizumab was the first angiogenesis inhibitor approved for the treatment of patients with advanced NSCLC in combination with chemotherapy ...
Manzo A +10 more
europepmc +5 more sources
Normal Wound Healing and Tumor Angiogenesis as a Game of Competitive Inhibition. [PDF]
PLoS ONE, 2016 Both normal wound healing and tumor angiogenesis are mitigated by the sequential, carefully orchestrated release of growth stimulators and inhibitors.
Irina Kareva +4 more
doaj +1 more source
Computational modelling of angiogenesis: The importance of cell rearrangements during vascular growth [PDF]
WIREs Mechanisms of Disease, e1634 (2023), 2023 Angiogenesis is the process wherein endothelial cells (ECs) form sprouts that elongate from the pre-existing vasculature to create new vascular networks. In addition to its essential role in normal development, angiogenesis plays a vital role in pathologies such as cancer, diabetes and atherosclerosis.
arxiv +1 more source
The Role of a Single Angiogenesis Inhibitor in the Treatment of Recurrent Glioblastoma Multiforme: A Meta-Analysis and Systematic Review. [PDF]
PLoS ONE, 2016 Currently, the standard treatment for newly diagnosed glioblastoma multiforme (GBM) is maximal safe surgical resection followed by radiation therapy with concurrent and adjuvant temozolomide.
Yawei Wang +4 more
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Frontiers in Cell and Developmental Biology, 2021 Aberrant regulation of angiogenesis involves in the growth and metastasis of tumors, but angiogenesis inhibitors fail to improve overall survival of pancreatic cancer patients in previous phase III clinical trials.
Xi Zhang +7 more
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Pharmaceuticals, 2010 Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. A number of endogenous angiogenesis inhibitors have been found in the body. The origin of these inhibitors is mostly extrinsic to the vasculature.
Yasufumi Sato
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Journal of Hematology & Oncology, 2016 Monoclonal antibodies and small molecule tyrosine kinase inhibitors (TKIs) directed against the vascular endothelial growth factor (VEGF) or its receptors have been investigated in several studies for the treatment of advanced gastric cancer (GC). In the
Jing Yu +5 more
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