Results 31 to 40 of about 1,147,332 (293)
Angiogenesis at the Interface between Basic and Clinical Research
The International Journal of Biological Markers, 1999 The field of antiangiogenesis has shown a remarkably rapid evolution from the discovery at the bench to translation into the clinic. Currently a wide variety of compounds are in clinical trial as inhibitors of angiogenesis, and new compounds are being ...
A. Albini, D. Noonan, L. Santi
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Anti-angiogenesis in prostate cancer: knocked down but not out
Asian Journal of Andrology, 2014 Angiogenesis is a very complex physiological process, which involves multiple pathways that are dependent on the homeostatic balance between the growth factors (stimulators and inhibitors).
Marijo Bilusic, Yu-Ning Wong
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Frontiers in Cell and Developmental Biology, 2021 Aberrant regulation of angiogenesis involves in the growth and metastasis of tumors, but angiogenesis inhibitors fail to improve overall survival of pancreatic cancer patients in previous phase III clinical trials.
Xi Zhang +7 more
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The angiogenic response to Bradykinin "in vitro" : the role of Bradykinin receptors in hypoxic hearts and tumors [PDF]
, 2004 End organ damage resulting from hypertension is a leading cause of morbidity and mortality worldwide. In hypertension, left ventricular mass increases resulting in left ventricular hypertrophy (LVH). LVH increases the risk of heart failure and sudden
Neysari, Shiva
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Exogenously added GPI-anchored tissue inhibitor of matrix metal loproteinase-1 (TIMP-1) displays enhanced and novel biological activities [PDF]
, 2004 The family of tissue inhibitors of metalloproteinases (TIMPs) exhibits diverse physiological/biological functions including the inhibition of active matrix metalloproteinases, regulation of proMMP activation, cell growth, and the modulation of ...
P.J. Nelson +9 more
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Angiogenesis, Thrombospondin-1 and Cervical Carcinogenesis
Taiwanese Journal of Obstetrics & Gynecology, 2005 Angiogenesis, the growth of new vessels from existing vasculature, plays an essential role in tumor development. The process involves interaction among cancer cells, endothelial cells, and components of the extracellular matrix, and is regulated by the ...
Ming-Ping Wu, Cheng-Yang Chou
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Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis [PDF]
, 2008 The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin ...
Rothmeier, Andrea S. +15 more
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Frontiers in Immunology, 2022 Angiogenesis in metastatic castration-resistant prostate cancer (mCRPC) has been extensively investigated as a promising druggable biological process. Nonetheless, targeting angiogenesis has failed to impact overall survival (OS) in patients with mCRPC ...
Antonio Giovanni Solimando +4 more
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Sex steroid regulation of angiogenesis in breast tissue
, 2005 Angiogenesis is essential for normal function in the female reproductive tract and a prerequisite for growth and metastasis of solid tumors. Several factors, both inducers and inhibitors, play essential roles in the regulation of the angiogenic process ...
Charlotta Dabrosin, Dabrosin, Charlotta,
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Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]
, 2003 Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito +6 more
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