Anti-Angiogenic Features of Endostatin in Obesity, Liver Fibrosis, and Hepatocellular Carcinoma [PDF]
BiomedicinesBackground/objectives: Endostatin is a cleavage product of collagen XVIII and a potent anti-angiogenic factor. Angiogenesis is essential for adipose tissue growth and contributes to liver fibrosis and cancer, suggesting a potential therapeutic role for ...
Thomas Grewal, Christa Buechler
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Endostatin inhibits VEGF-A induced osteoclastic bone resorption
BMC Musculoskeletal Disorders, 2006 Background Endostatin is a C-terminal fragment of collagen XVIII which is a component of basement membranes with the structural properties of both collagens and proteoglycans.
Ilvesaro Joanna +4 more
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Recombinant Human Endostatin Suppressed the Biological Behavior of Human Umbilical Vein Endothelial Cells Under Hypoxic and Hypoxic/Starvation Conditions In Vitro [PDF]
Analytical Cellular PathologyRecombinant human endostatin (rh-endostatin) has been shown to act as an inhibitor of angiogenesis. Previous studies have indicated that rh-endostatin combined with chemotherapy can improve the objective response rate (ORR), time to progression (TTP ...
Yongsheng Jia +5 more
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Plasma endostatin and its association with new-onset acute kidney injury in critical care [PDF]
Journal of Intensive CareBackground Endostatin is a promising biomarker for predicting acute kidney injury (AKI) and mortality in the intensive care unit (ICU). We investigated plasma endostatin levels at ICU admission as predictors of new-onset AKI within 48 h after ICU ...
Hazem Koozi +5 more
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Plasma endostatin at intensive care admission is independently associated with acute kidney injury, dialysis, and mortality in COVID-19 [PDF]
Intensive Care Medicine ExperimentalBackground Critical COVID-19 is associated with high mortality, and acute kidney injury (AKI) is common. Endostatin has emerged as a promising prognostic biomarker for predicting AKI and mortality in intensive care. This study aimed to investigate plasma
Hazem Koozi +7 more
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Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study [PDF]
BMJ OpenObjective The aim of this study was to assess associations between endostatin levels and short-term mortality in unsorted acute hospitalised dyspnoea patients with or without congestive heart failure (CHF), adjusted for common cardiovascular risk factors.
Axel C Carlsson +5 more
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ERJ Open Research, 2021 Currently available noninvasive markers for assessing disease severity and mortality risk in pulmonary arterial hypertension (PAH) are unrelated to fundamental disease biology.
Catherine E. Simpson +15 more
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Endostatin's endpoints—Deciphering the endostatin antiangiogenic pathway [PDF]
Cancer Cell, 2004 Up until now, the precise mechanism for endostatin's antiangiogenesis action was not known. In a recent report, have taken advantage of gene array and proteomic analysis to map the antiangiogenic pathways turned on by endostatin. This study resolves some of the controversies surrounding endostatin's biology, and provides a new direction to help dissect
Benezra, Robert, Rafii, Shahin
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Biomedicines, 2021 Endostatin may predict mortality and kidney impairment in general populations as well as in critically ill patients. We decided to explore the possible role of endostatin as a predictor of 30-day mortality, acute kidney injury (AKI), and renal ...
Toralph Ruge +5 more
doaj +1 more source
BMC Molecular and Cell Biology, 2020 Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai +4 more
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