Results 1 to 10 of about 445 (114)
Unraveling the Mysteries of Endostatin [PDF]
IUBMB Life, 2009 Abstract Endostatin, a 20‐kDa C‐terminal proteolytic fragment of collagen XVIII, is a specific endogenous angiogenesis inhibitor discovered more than a decade. The structure, stability, and mechanism of actions of endostatin have been extensively investigated during the past 12 years, among which controversial reports remain ...
Yongzhang Luo, Nan Song, Yujie Huang
exaly +3 more sources
Autoantibodies to Endostatin in Patients With Breast Cancer: Correlation to Endostatin Levels and Clinical Outcome [PDF]
British Journal of Cancer, 2006 Circulating autoantibodies to self-antigens overexpressed by cancer cells are common in cancer patients. As specific proteins are expressed during neoangiogenesis, a similar phenomenon might occur with particular antigens of tumour vessels. Collagen XVIII, from which endostatin is cleaved, is highly expressed in the perivascular basement membrane of ...
Didier Wion, Jean-Yves Blay
exaly +4 more sources
Endostatin in Renal and Cardiovascular Diseases
Kidney Diseases, 2021 Endostatin, a protein derived from the cleavage of collagen XVIII by the action of proteases, is an endogenous inhibitor known for its ability to inhibit proliferation and migration of endothelial cells, angiogenesis, and tumor growth.
Mei Li +4 more
doaj +3 more sources
Endostatin's endpoints—Deciphering the endostatin antiangiogenic pathway [PDF]
Cancer Cell, 2004 Up until now, the precise mechanism for endostatin's antiangiogenesis action was not known. In a recent report, have taken advantage of gene array and proteomic analysis to map the antiangiogenic pathways turned on by endostatin. This study resolves some of the controversies surrounding endostatin's biology, and provides a new direction to help dissect
Benezra, Robert, Rafii, Shahin
openaire +2 more sources
Biomedicines, 2021 Endostatin may predict mortality and kidney impairment in general populations as well as in critically ill patients. We decided to explore the possible role of endostatin as a predictor of 30-day mortality, acute kidney injury (AKI), and renal ...
Toralph Ruge +5 more
doaj +1 more source
Kidney & Blood Pressure Research, 2020 Background/Aims: Renal vascular injury accounts for the poor outcomes of patients with IgA nephropathy (IgAN). In this study, we investigated whether endostatin, a potent inhibitor of angiogenesis, is associated with IgAN.
Yaling Zhai +5 more
doaj +1 more source
ERJ Open Research, 2021 Currently available noninvasive markers for assessing disease severity and mortality risk in pulmonary arterial hypertension (PAH) are unrelated to fundamental disease biology.
Catherine E. Simpson +15 more
doaj +1 more source
BMC Molecular and Cell Biology, 2020 Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai +4 more
doaj +1 more source
The Roles of Vascular Endothelial Growth Factor, Angiostatin, and Endostatin in Nasal Polyp Development [PDF]
Journal of Rhinology, 2022 Background and Objectives Microvascular remodeling and angiogenesis are elements of tissue remodeling characteristic of chronic inflammatory diseases, including nasal polyps (NPs).
Tae Ui Hong, Seong Kook Park
doaj +1 more source
Antiangiogenesis signals by endostatin [PDF]
The FASEB Journal, 2001 ABSTRACT Endostatin is a potent endogenous angiogenesis inhibitor that induces regression of tumors in mice. Neither an extracellular receptor for endostatin nor intracellular signals that result in the regression of tumor vascular beds have been identified.
M, Shichiri, Y, Hirata
openaire +2 more sources