Results 11 to 20 of about 7,550 (174)

Anti-Angiogenic Features of Endostatin in Obesity, Liver Fibrosis, and Hepatocellular Carcinoma [PDF]

Biomedicines
Background/objectives: Endostatin is a cleavage product of collagen XVIII and a potent anti-angiogenic factor. Angiogenesis is essential for adipose tissue growth and contributes to liver fibrosis and cancer, suggesting a potential therapeutic role for ...
Thomas Grewal, Christa Buechler
doaj   +2 more sources

Serum endostatin is selectively reduced in non-steatotic chronic hepatitis C and normalizes after direct-acting antiviral therapy: a prospective cohort study [PDF]

BMC Gastroenterology
Background Endostatin is an endogenous inhibitor of angiogenesis that has been linked to chronic liver disease and proposed as a circulating marker of fibrosis in hepatitis C virus (HCV) infection.
Kilian Weigand, Georg Peschel, Martina Müller, Christa Buechler   +3 more
doaj   +2 more sources

Liver Cirrhosis and Septic Shock Attenuate the Increase in Plasma Endostatin Concentrations That Is Associated with Acute Kidney Injury Requiring Dialysis [PDF]

Biomedicines
Background/Objectives: Sepsis is a life-threatening syndrome characterized by a dysregulated host response to infection. Alterations in pro- and anti-angiogenic mediators have been associated with disease severity and clinical outcomes.
Lorena Fröhlich, Caroline Fromm, Lea Läber, Veronika Gepperth, Stephan Schmid, Martina Müller, Patricia Mester, Vlad Pavel, Christa Buechler   +8 more
doaj   +2 more sources

An update on the landscape of collagen bioactive fragments [PDF]

The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +2 more sources

MMP-2 associated imbalance of VEGF/Endostatin is linked to suppression of the PI3K/AKT/HIF-1α pathway in steroid-induced osteonecrosis of femoral head. [PDF]

PLoS ONE
ObjectiveTo investigate the role of matrix metalloproteinase-2 (MMP-2) and the imbalance between vascular endothelial growth factor (VEGF) and Endostatin in the pathogenesis of steroid-induced osteonecrosis of femoral head (SONFH).MethodsClinical samples
Guangyang Zhang, Zhaopu Jing, Jialin Liang, Leifeng Lv, Xiaoqian Dang, Qichun Song   +5 more
doaj   +2 more sources

ApoE‐ and Cfh‐deficient mice exhibit structural and molecular features of human early–intermediate retinal degeneration [PDF]

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1420-1435, July 2026.
Age‐related macular degeneration (AMD) involves lipid dysregulation and complement overactivation. Here, we characterize a double‐knockout ApoE−/−/Cfh−/− mouse as a model of early–intermediate retinal degeneration. These mice exhibit retinal pigment epithelium thinning, Bruch's membrane thickening, lipid accumulation, enhanced C5b‐9 deposition ...
Sergio Recalde, Maite Moreno Orduña, Jaione Bezunartea, Idoia Belza, Ainara Chas, Laura Fernández‐Sánchez, Nicolás Cuenca Navarro, Alfredo García‐Layana, Patricia Fernández‐Robredo, María Hernández   +9 more
wiley   +2 more sources

Recombinant Human Endostatin Suppressed the Biological Behavior of Human Umbilical Vein Endothelial Cells Under Hypoxic and Hypoxic/Starvation Conditions In Vitro [PDF]

Analytical Cellular Pathology
Recombinant human endostatin (rh-endostatin) has been shown to act as an inhibitor of angiogenesis. Previous studies have indicated that rh-endostatin combined with chemotherapy can improve the objective response rate (ORR), time to progression (TTP ...
Yongsheng Jia, Cuicui Zhang, Jimin Zhao, Chuanxiang Hu, Xiaoyong Yang, Yan Zhang   +5 more
doaj   +2 more sources

Plasma endostatin and its association with new-onset acute kidney injury in critical care [PDF]

Journal of Intensive Care
Background Endostatin is a promising biomarker for predicting acute kidney injury (AKI) and mortality in the intensive care unit (ICU). We investigated plasma endostatin levels at ICU admission as predictors of new-onset AKI within 48 h after ICU ...
Hazem Koozi, Jonas Engström, Anders Larsson, Martin Spångfors, Hans Friberg, Attila Frigyesi   +5 more
doaj   +2 more sources

Plasma endostatin at intensive care admission is independently associated with acute kidney injury, dialysis, and mortality in COVID-19 [PDF]

Intensive Care Medicine Experimental
Background Critical COVID-19 is associated with high mortality, and acute kidney injury (AKI) is common. Endostatin has emerged as a promising prognostic biomarker for predicting AKI and mortality in intensive care. This study aimed to investigate plasma
Hazem Koozi, Jonas Engström, Ahmad Zwawi, Martin Spångfors, Ingrid Didriksson, Anders Larsson, Hans Friberg, Attila Frigyesi   +7 more
doaj   +2 more sources

Basement membrane product, endostatin, as a link between inflammation, coagulation and vascular permeability in COVID-19 and non-COVID-19 acute respiratory distress syndrome

Frontiers in Immunology, 2023
BackgroundImmune cell recruitment, endothelial cell barrier disruption, and platelet activation are hallmarks of lung injuries caused by COVID-19 or other insults which can result in acute respiratory distress syndrome (ARDS).
Katharina Jandl, Katharina Jandl, Johannes Lorenz Berg, Johannes Lorenz Berg, Anna Birnhuber, Anna Birnhuber, Elisabeth Fliesser, Izabela Borek, Benjamin Seeliger, Sascha David, Julius J. Schmidt, Gregor Gorkiewicz, Martin Zacharias, Tobias Welte, Horst Olschewski, Horst Olschewski, Akos Heinemann, Malgorzata Wygrecka, Malgorzata Wygrecka, Grazyna Kwapiszewska, Grazyna Kwapiszewska, Grazyna Kwapiszewska   +21 more
doaj   +1 more source