Results 11 to 20 of about 14,946 (225)

Circulating angiogenesis-related biomarkers in sickle cell retinopathy and maculopathy. [PDF]

Br J Haematol
Summary Sickle cell disease (SCD), encompassing genotypes such as HbSS and HbSC, leads to retinal complications such as sickle cell retinopathy (SCR) and maculopathy (SCM) through poorly understood mechanisms. This study explored associations of a panel of circulating angiogenesis‐related factors with SCR and SCM.
Brandsen RP, Klaassen I, de Caluwe R, Nur E, Biemond BJ, Diederen RMH, Schlingemann RO.   +6 more
europepmc   +2 more sources

The Promise of Chemotherapy-Free Strategies in Advanced Driver-Negative NSCLC: A Systematic Review and Network Meta-Analysis of Antiangiogenic Combination Therapies. [PDF]

Cancer Med
ABSTRACT Background Antiangiogenic combination therapy—antiangiogenic agents combined with immune checkpoint inhibitors and/or chemotherapy—has become an important treatment strategy for advanced driver‐negative non‐small cell lung cancer (NSCLC). We conducted a network meta‐analysis to compare efficacy and safety and identify optimal antiangiogenic ...
Li Z, Zhao W, Guo W, Lu X, Jia C, Ma J, Zhou Q, Yang X, Jiang J.   +8 more
europepmc   +2 more sources

Elevated Endostatin Expression Is Regulated by the pIgA Immune Complex and Associated with Disease Severity of IgA Nephropathy

Kidney & Blood Pressure Research, 2020
Background/Aims: Renal vascular injury accounts for the poor outcomes of patients with IgA nephropathy (IgAN). In this study, we investigated whether endostatin, a potent inhibitor of angiogenesis, is associated with IgAN.
Yaling Zhai, Xiaoqing Long, Jingge Gao, Xingchen Yao, Xinnian Wang, Zhanzheng Zhao   +5 more
doaj   +1 more source

Basement membrane product, endostatin, as a link between inflammation, coagulation and vascular permeability in COVID-19 and non-COVID-19 acute respiratory distress syndrome

Frontiers in Immunology, 2023
BackgroundImmune cell recruitment, endothelial cell barrier disruption, and platelet activation are hallmarks of lung injuries caused by COVID-19 or other insults which can result in acute respiratory distress syndrome (ARDS).
Katharina Jandl, Katharina Jandl, Johannes Lorenz Berg, Johannes Lorenz Berg, Anna Birnhuber, Anna Birnhuber, Elisabeth Fliesser, Izabela Borek, Benjamin Seeliger, Sascha David, Julius J. Schmidt, Gregor Gorkiewicz, Martin Zacharias, Tobias Welte, Horst Olschewski, Horst Olschewski, Akos Heinemann, Malgorzata Wygrecka, Malgorzata Wygrecka, Grazyna Kwapiszewska, Grazyna Kwapiszewska, Grazyna Kwapiszewska   +21 more
doaj   +1 more source

The Roles of Vascular Endothelial Growth Factor, Angiostatin, and Endostatin in Nasal Polyp Development [PDF]

Journal of Rhinology, 2022
Background and Objectives Microvascular remodeling and angiogenesis are elements of tissue remodeling characteristic of chronic inflammatory diseases, including nasal polyps (NPs).
Tae Ui Hong, Seong Kook Park
doaj   +1 more source

Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy [PDF]

, 2017
BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis ...
Afeltra, Antonella M. Vittoria, Amoroso, Antonio, Barbano, Biagio, Cianci, Rosario, Gigante, Antonietta, Margiotta, Domenico, Navarini, Luca, Rosato, Edoardo   +7 more
core   +1 more source

Endostatin gene variation and protein levels in breast cancer susceptibility and severity

BMC Cancer, 2007
Background Endostatin is a potent endogenous anti-angiogenic agent which inhibits tumour growth. A non-synonymous coding polymorphism in the Endostatin gene is thought to affect Endostatin activity.
Cox Angela, Globe Jenny, Cross Simon S, Balasubramanian Sabapathy P, Brown Nicola J, Reed Malcolm W   +5 more
doaj   +1 more source

Endostatin induces normalization of blood vessels in colorectal cancer and promotes infiltration of CD8+ T cells to improve anti-PD-L1 immunotherapy

Frontiers in Immunology, 2022
IntroductionThe purpose of this study was to evaluate recombinant human endostatin (rHE)-induced normalization of the tumor vasculature in colorectal cancer (CRC) and to evaluate the therapeutic effects of combined treatment with rHE and a programmed ...
Xiao-Dong Chu, Hui Bao, Yu-Jian Lin, Ruo-Xi Chen, Yi-Ran Zhang, Ting Huang, Jia-Shuai He, Shu-Chen Huangfu, Yun-Long Pan, Hui Ding   +9 more
doaj   +1 more source

Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function. [PDF]

, 2014
STUDY QUESTION Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?
A. E. Wallace, A. P. Johnstone, Athanassiades, Cartwright, Choy, Desai, Engert, Fraser, Furuya, G. S. Whitley, Hanna, J. E. Cartwright, Karamouzis, Kim, King, King, Koga, Meekins, Melchiorre, Moroianu, Nasu, Pijnenborg, Pijnenborg, Pollheimer, Prefumo, Prefumo, R. Fraser, Rehn, S. Gurung, S. S. Goulwara, Santoni, Treiber-Held, van der Harten, Verma, Wei, Zhou   +35 more
core   +2 more sources

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. [PDF]

, 2018
Stroke is the primary cause of disability due to the brain's limited ability to regenerate damaged tissue. After stroke, an increased inflammatory and immune response coupled with severely limited angiogenesis and neuronal growth results in a stroke ...
Carmichael, S Thomas, Gojgini, Shiva, Nih, Lina R, Segura, Tatiana   +3 more
core   +1 more source