Results 21 to 30 of about 7,550 (174)

Endostatin gene variation and protein levels in breast cancer susceptibility and severity

BMC Cancer, 2007
Background Endostatin is a potent endogenous anti-angiogenic agent which inhibits tumour growth. A non-synonymous coding polymorphism in the Endostatin gene is thought to affect Endostatin activity.
Cox Angela, Globe Jenny, Cross Simon S, Balasubramanian Sabapathy P, Brown Nicola J, Reed Malcolm W   +5 more
doaj   +1 more source

Circulatory endostatin level and risk of cardiovascular events in patients with end-stage renal disease on hemodialysis [PDF]

Kidney Research and Clinical Practice
Background Endostatin is released during extracellular matrix remodeling and is involved in the development of vascular pathology and cardiovascular (CV) disease. However, the role of circulating endostatin as a biomarker of vascular calcification and CV
Jin Sug Kim, Miji Kim, Kyung Hwan Jeong, Ju-Young Moon, Sang Ho Lee, Gang Jee Ko, Dong-Young Lee, So Young Lee, Yang Gyun Kim, Hyeon Seok Hwang   +9 more
doaj   +1 more source

Endostatin in fibrosis and as a potential candidate of anti-fibrotic therapy

Drug Delivery, 2021
Fibrotic diseases pose significant clinical challenges due to their broadness and complexity. Thus, a better understanding of fibrogenesis and the development of more effective treatments is imperative. Recent evidence suggests a significant antifibrotic
Zequn Zhang, Xi Liu, Zhaolong Shen, Jun Quan, Changwei Lin, Xiaorong Li, Gui Hu   +6 more
doaj   +1 more source

Real‐world outcomes of various regimens of recombinant human endostatin combined with chemotherapy in non‐driver gene mutation advanced non‐small cell lung cancer

Cancer Medicine, 2019
Aims This real‐world study is conducted to evaluate the efficacy and safety of recombinant human endostatin (rh‐endostatin) combined with chemotherapy as first‐line treatment for non‐driver genes mutation non‐small cell lung cancer (NSCLC) patients, and ...
Zhongtai Wang, Hui Zhang, Chunhua Zhou, Xiaoyan Long, Rui Guan, Nong Yang, Yongchang Zhang   +6 more
doaj   +1 more source

Endostatin induces normalization of blood vessels in colorectal cancer and promotes infiltration of CD8+ T cells to improve anti-PD-L1 immunotherapy

Frontiers in Immunology, 2022
IntroductionThe purpose of this study was to evaluate recombinant human endostatin (rHE)-induced normalization of the tumor vasculature in colorectal cancer (CRC) and to evaluate the therapeutic effects of combined treatment with rHE and a programmed ...
Xiao-Dong Chu, Hui Bao, Yu-Jian Lin, Ruo-Xi Chen, Yi-Ran Zhang, Ting Huang, Jia-Shuai He, Shu-Chen Huangfu, Yun-Long Pan, Hui Ding   +9 more
doaj   +1 more source

Endostatin inhibits VEGF-A induced osteoclastic bone resorption in vitro

BMC Musculoskeletal Disorders, 2006
Background Endostatin is a C-terminal fragment of collagen XVIII which is a component of basement membranes with the structural properties of both collagens and proteoglycans.
Ilvesaro Joanna, Hautala Timo, Nelo Katri, Sipola Annina, Tuukkanen Juha   +4 more
doaj   +1 more source

Combining Bevacizumab with Endostatin Gets Better Antitumor Efficacy in Vivo 
in Lung Cancer Animal Model

Chinese Journal of Lung Cancer, 2013
Background and objective The aim of this study is to investigate difference of antiangiogenesis ablility and interaction about bevacizumab and endostatin in vivo in lung cancer animal model.
Niu NIU, Baolan LI, Chaoyang LIU, Ying HU, Xuebing LI, Jie LI, Heling SHI, Haiqing ZHANG   +7 more
doaj   +1 more source

Recombinant human endostatin combined with radiotherapy inhibits colorectal cancer growth

BMC Cancer, 2017
Background To examine the effects of recombinant human endostatin combined with radiotherapy on colorectal cancer HCT-116 cell xenografts in nude mice. Methods Forty male BALB/c nude mice were injected with human colorectal cancer HCT-116 cells to form ...
Ke Zhang, Ye Wang, Xiaoli Yu, Yanyan Shi, Yasai Yao, Xiaofang Wei, Xuezhen Ma   +6 more
doaj   +1 more source

Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis

Orphanet Journal of Rare Diseases, 2019
Endostatin is a naturally occurring collagen fragment with anti-angiogenic properties. We investigated the association between serum endostatin levels and DLCO in a cohort of patients with lymphangioleiomyomatosis (LAM). Associations of endostatin levels
Anthony M. Lamattina, Sergio Poli, Pranav Kidambi, Shefali Bagwe, Andrew Courtwright, Pierce H. Louis, Shikshya Shrestha, Benjamin Stump, Hilary J. Goldberg, Elizabeth A. Thiele, Ivan Rosas, Elizabeth P. Henske, Souheil El-Chemaly   +12 more
doaj   +1 more source

Endostatin a Potential Biomarker for Heart Failure with Preserved Ejection Fraction

Arquivos Brasileiros de Cardiologia, 2017
Background: Endostatin is a circulating endogenous angiogenesis inhibitor preventing neovascularization. Previous studies demonstrated the prognostic value of Endostatin among patients with heart failure with reduced ejection fraction (HFrEF).
Michael Coll Barroso, Philip Boehme, Frank Kramer, Thomas Mondritzki, Till Koehler, Jan-Erik Gülker, Martin Karoff, Wilfried Dinh   +7 more
doaj   +1 more source