Results 31 to 40 of about 7,550 (174)

Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog [PDF]

Chinese Journal of Cancer, 2016
Endostatin (ES) is a well-established potent endogenous antiangiogenic factor. An ES variant, called zinc-binding protein-ES (ZBP-ES), is clinically available; however, its use is limited by rapid renal clearance and short residence time. PEGylation has been exploited to overcome these shortcomings, and mono-PEGylated ES (called M2ES) as well as mono ...
Shan Wang, Yan Fu, Yongzhang Luo
openaire   +3 more sources

Endostatin in the pancreas [PDF]

British Journal of Cancer, 2005
In this issue of the British Journal of Cancer, Brammer and co-workers investigate the status of endostatin expression in human pancreas cancer and normal pancreatic tissue. Endostatin was originally identified from the conditioned media of glioendothelioma cells as an inhibitor of angiogenesis (O'Reilly et al, 1997).
openaire   +2 more sources

Association of Endostatin D104N with Leukemia [PDF]

The Kaohsiung Journal of Medical Sciences, 2003
The bone marrow and/or peripheral blood from 126 patients with acute myeloid leukemia (AML), 57 with chronic myeloid leukemia (CML), 91 with acute lymphocytic leukemia (ALL), and 178 normal controls were analyzed using a polymerase chain reaction‐restriction fragment length polymorphism (RFLP) assay to evaluate the association of the endostatin ...
Liu, Ta-Chih, Lin, Shen-Fung, Chang, Chao-Sung, Chen, Tyen-Po, Peng, Ching-Tien, Chang, Jan-Gowth   +5 more
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Placental malperfusion and angiogenesis‐related proteins are associated with small‐for‐gestational‐age in systemic lupus erythematosus

Journal of Internal Medicine, EarlyView.
Abstract Background Although systemic lupus erythematosus (SLE) pregnancy frequently results in small for gestational age (SGA) infants, the understanding of underlying mechanisms is limited. We aimed to identify specific histological patterns of placental injury in SGA in SLE and to explore whether an altered balance of angiogenesis‐related proteins ...
Marit Stockfelt, Henri Puttonen, Ing‐Marie Fyhr, Agnes Torell, Kerstin Andersson, Iva Gunnarsson, Elisabet Svenungsson, Agneta Zickert, Maria Majczuk Sennström, Estelle Trysberg, Anders A. Bengtsson, Andreas Jönsen, Helena Strevens, Christopher Sjöwall, Muna Saleh, Sofia Pihl, Dag Leonard, Lars Rönnblom, Tansim Akhter, Bo Jacobsson, Anna‐Carin Lundell, Anna Rudin   +21 more
wiley   +1 more source

Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2–mediated angiogenesis

Tumor Biology, 2017
Several studies have revealed the potential of normalizing tumor vessels in anti-angiogenic treatment. Recombinant human endostatin is an anti-angiogenic agent which has been applied in clinical tumor treatment.
Fan Pan, Wende Yang, Wei Li, Xiao-Yan Yang, Shuhao Liu, Xin Li, Xiaoxu Zhao, Hui Ding, Li Qin, Yunlong Pan   +9 more
doaj   +1 more source

Cellular Actions and Signaling by Endostatin [PDF]

Critical Reviews™ in Eukaryotic Gene Expression, 2002
The malignant transformation of a normal cell into a cancer cell requires no vasculature. Growth of solid tumors, however, requires angiogenesis to provide oxygen and nutrients to support cell proliferation. The switch from an avascular to a vascular phenotype is typically associated with acceleration of tumor growth. Antiangiogenic therapy, starving a
Ramani, Ramchandran, S Ananth, Karumanchi, Jun-ichi, Hanai, Seth L, Alper, Vikas P, Sukhatme   +4 more
openaire   +2 more sources

Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia

Oral Diseases, EarlyView.
ABSTRACT Background We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Methods Tissue sections of OL transforming into OSCC (leuko‐ca), the corresponding OSCC and OL that did not progress to OSCC (leuko‐nonca) were analyzed with global relative ...
Daniel Giglio, Divya Ganesh, Bishwa Prakash Bhattarai, Tine Merete Søland, Jonas Sundberg, Annika Thorsell, Jenny Öhman, Dipak Sapkota, Bengt Hasséus   +8 more
wiley   +1 more source

Serum Endostatin Levels in Oral Squamous Cell Carcinoma [PDF]

Iranian Journal of Otorhinolaryngology, 2018
Introduction: Endostatin is a C-­terminal proteolytic fragment of collagen XVIII and, as with angiostatin and thrombospondin, is known as an anti­angiogenic agent.
Maryam Mardani, Azadeh Andisheh-Tadbir, Mohammad Ali Ranjbar, Bijan Khademi, Mohammad Javad Fattahi, Ahmad Rahbar   +5 more
doaj   +1 more source

Targeting Integrins in Triple Negative Breast Cancer: Therapeutic Potential of Monoclonal Antibodies, PARP Inhibitors, Synthetic Peptides, and Aptamers

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Triple‐negative breast cancers (TNBCs) are associated with poor prognosis and chemoresistance. Recent reports indicate that extracellular matrix (ECM) molecules, such as integrins, could influence TNBC development. Integrins are adhesion macromolecules that modulate ECM characteristics such as stiffening of ECM and being associated with ...
Mobina Darabi, Zeynab Zahedi, Kosar Zolfaghari, Alireza Kordi, Kiarash Saleki, Niloufar Yazdanpanah, Nima Rezaei   +6 more
wiley   +1 more source

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu, Qin Huang, Zixuan Ding, Lin Fu, Mu Yang, Bi Peng, Pengbo Hu, Yuanhui Liu   +7 more
wiley   +1 more source