Results 41 to 50 of about 7,550 (174)

Recombined humanized endostatin‐induced suppression of HMGB1 expression inhibits proliferation of NSCLC cancer cells

Thoracic Cancer, 2019
Background Recombined humanized endostatin (Rh‐endostatin) exhibits a potent anti‐cancer effect involving multiple molecular targets and signaling pathways. HMGB1 is a highly conserved DNA‐binding protein involved in cancer development.
Fan‐Jie Meng, Shuo Wang, Yi‐Jie Yan, Chun‐Yang Wang, Zhi‐Yu Guan, Jun Zhang   +5 more
doaj   +1 more source

Vascular Endothelial Growth FactorC Serum and Endostatin Serum as Predictors of Lympho Vascular Invasion in Early Stage Cervical Cancer

Indonesian Journal of Obstetrics and Gynecology, 2017
Objective: To determine the relationship of Vascular Endothelial Growth Factors-C (VEGF-C), endostatin and the ratio of VEGF-C/ endostatin with limfo vascular invasion in patient with early stage cervical cancer.
Andhinna Rusmardiani, Syahrul Rauf, Efendi Lukas   +2 more
doaj   +1 more source

Small Proteoglycans, Big Impact: Decorin, Biglycan, and Asporin in Musculoskeletal Tissue Health and Disease

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT The extracellular matrix (ECM) is a dynamic and information‐rich network that integrates structural support with biochemical and mechanical signaling. Among its key regulatory components are the Small Leucine‐Rich Proteoglycans (SLRPs), a family of matrix molecules that coordinate extracellular architecture with cell signaling.
Alessandra Leone, Zsuzsa Jenei‐Lanzl, Frank Zaucke   +2 more
wiley   +1 more source

Mechanistic Pathways of Wound Healing: From Hemostasis to Scar‐Free Regeneration

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.
Devadass Jessy Mercy, Koyeli Girigoswami, Agnishwar Girigoswami   +2 more
wiley   +1 more source

Anti-tumor therapy with macroencapsulated endostatin producer cells

BMC Biotechnology, 2010
Background Theracyte is a polytetrafluoroethylene membrane macroencapsulation system designed to induce neovascularization at the tissue interface, protecting the cells from host's immune rejection, thereby circumventing the problem of limited half-life ...
Balduino Keli N, Chura-Chambi Rosa M, da Costa Patrícia LN, Malavasi Natália V, Chammas Roger, Rodrigues Danielle B, Morganti Ligia   +6 more
doaj   +1 more source

Circulating Serum AGRN and ADAMTS8 With Related Candidates as Potential Biomarkers for Carotid Plaque Presence and Vulnerability

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This study investigated serum AGRN and ADAMTS8 as biomarkers for carotid plaques within human participants. Results showed a significant correlation with plaque presence, yielding a moderate combined diagnostic performance. However, these markers poorly differentiated plaque vulnerability.
Shuaiwei Guo, Shengyan Cui, Xiao Zhang, Zixuan Xing, Yixin Sun, Mingqian Qin, Xiaoying Ma, Xiangyu Li, Yan Ma, Peng Gao, Yanfei Chen, Yabing Wang, Bin Yang, Jian Chen, Fei Chen, Xia Lu, Jiaqi Jin, Liqun Jiao, Tao Wang   +18 more
wiley   +1 more source

Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function

Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley   +1 more source

Validation of an enzyme-linked immunosorbent assay (ELISA) for quantification of endostatin levels in mice as a biomarker of developing glomerulonephritis.

PLoS ONE, 2019
Endostatin, the C-terminal fragment of type XVIII collagen, was shown to be one of the most potent endothelial cell-specific inhibitors of angiogenesis.
Jacqueline Wallwitz, Petra Aigner, Elisabeth Gadermaier, Eva Bauer, Emilio Casanova, Anton Bauer, Dagmar Stoiber   +6 more
doaj   +1 more source

Endostatin for fibrosis [PDF]

Science-Business eXchange, 2012
University of Pittsburgh researchers have identified fibrosis as a potential new indication for the cancer therapeutic endostatin. The team designed a modified version of the peptide that reversed fibrosis in ex vivo human skin models and in mice.
openaire   +1 more source

Genetic Association Studies in Hepatocellular Carcinoma: Systematic Meta‐Analyses, a Comprehensive Field Synopsis, and Epidemiological Evidence

MedComm, Volume 7, Issue 9, September 2026.
Based on meta‐analyses and cumulative epidemiological evidence, the present study identifies 11 genetic variants in 11 genes that are truly associated with the risk of hepatocellular carcinoma. Our work presents a systematic synopsis, which helps elucidate the mechanisms of carcinogenesis and provides insights into the early diagnosis and novel ...
Yujin Shi, Bin Huang, Xiaohong Liu, Yalan Liu, Qinyong Hu, Tianyu Lei, Luqi Tang, Guanglin Xiao, Tingting Ning, Shengqin Yue, Jiahui He, Qilian Du, Xuanmei Li, Yixuan Zhou, Qiongfang Zhang, Chunyan Qi, Hong Ren, Hong‐Gang Ren   +17 more
wiley   +1 more source