Results 41 to 50 of about 14,946 (225)

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Validation of an enzyme-linked immunosorbent assay (ELISA) for quantification of endostatin levels in mice as a biomarker of developing glomerulonephritis.

PLoS ONE, 2019
Endostatin, the C-terminal fragment of type XVIII collagen, was shown to be one of the most potent endothelial cell-specific inhibitors of angiogenesis.
Jacqueline Wallwitz, Petra Aigner, Elisabeth Gadermaier, Eva Bauer, Emilio Casanova, Anton Bauer, Dagmar Stoiber   +6 more
doaj   +1 more source

Vascular Endothelial Growth FactorC Serum and Endostatin Serum as Predictors of Lympho Vascular Invasion in Early Stage Cervical Cancer

Indonesian Journal of Obstetrics and Gynecology, 2017
Objective: To determine the relationship of Vascular Endothelial Growth Factors-C (VEGF-C), endostatin and the ratio of VEGF-C/ endostatin with limfo vascular invasion in patient with early stage cervical cancer.
Andhinna Rusmardiani, Syahrul Rauf, Efendi Lukas   +2 more
doaj   +1 more source

Intrapleural Administration With Rh-Endostatin and Chemical Irritants in the Control of Malignant Pleural Effusion: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2021
IntroductionA modified and recombinant human endostatin (Rh-endostatin) is often used in the control of malignant pleural effusion (MPE) through intrapleural infusion.ObjectivesTo demonstrate the clinical response, survival, and safety of Rh-endostatin ...
Cheng-Qiong Wang, Cheng-Qiong Wang, Xiao-Rong Huang, Min He, Xiao-Tian Zheng, Xiao-Tian Zheng, Hong Jiang, Hong Jiang, Qian Chen, Teng-Yan Fan, Teng-Yan Fan, Lin Zhan, Juan Ling, Ji-Hong Feng, Xue Xiao, Xue Xiao, Xiao-Fan Chen, Zheng Xiao, Zheng Xiao   +18 more
doaj   +1 more source

Endostatin concentration in plasma of healthy human volunteers [PDF]

, 2017
Background: Angiogenesis is involved in many cardiovascular and cancerous diseases, including atherosclerosis and is controlled by a fine balance between angiogenic and angiostatic mediators.
Baxendale, Ronald Hugh, Fatima, Sadia, Habib, Syed Hamid, Khan, Muhammad Jaffar, Malik, Muhammad Omar, Shah, Inayat   +5 more
core  

Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]

, 2020
Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I, Tabish, Tanveer A, Whatmore, Jacqueline L, Zhang, Shaowei   +3 more
core   +2 more sources

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Tendinopathy—from basic science to treatment [PDF]

, 2008
Chronic tendon pathology (tendinopathy), although common, is difficult to treat. Tendons possess a highly organized fibrillar matrix, consisting of type I collagen and various 'minor' collagens, proteoglycans and glycoproteins.
A McCormick, AH Drummond, AJ Banes, AN Bamji, AN Corps, AN Corps, AN Corps, AP D'Vaz, B Pasternak, BL Woodley, BM Clancy, CA Speed, D Bjur, EM Badley, G Puddu, G Riley, GAC Murrell, GC Jones, GC Jones, GP Riley, GP Riley, Graham Riley, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Langberg, H Langberg, H Langberg, H Nagase, HA Awad, J Archambault, JA Paoloni, JA Paoloni, JA Paoloni, JD Rompe, JE Carpenter, JL Cook, JM Archambault, L Józsa, L Ohberg, LC Almekinders, LJ McCawley, M Aström, M Benjamin, M Gotoh, M Gotoh, M Lavagnino, M Lavagnino, MD Chard, ME Jones, MH Khan, N Mafi, P Burssens, P Kannus, R Salingcarnboriboon, RA Bank, RF Ker, RK Smith, SA Fenwick, SC Fu, SG Rees, SP Arnoczky, T Pufe, T Pufe, T Samiric, TG Gerich, TW Ehlers, UM Wewer   +69 more
core   +1 more source

Endostatin's Antiangiogenic Signaling Network

Molecular Cell, 2004
It is here demonstrated that the set of gene expressions underlying the angiogenic balance in tissues can be molecularly reset en masse by a single protein. Using genome-wide expression profiling, coupled with RT-PCR and phosphorylation analysis, we show that the endogenous angiogenesis inhibitor endostatin downregulates many signaling pathways in ...
Abdollahi, Amir, Hahnfeldt, Philip, Maercker, Christian, Gröne, Hermann-Josef, Debus, Juergen, Ansorge, Wilhelm, Folkman, Judah, Hlatky, Lynn, Huber, Peter E   +8 more
openaire   +2 more sources

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source