Results 61 to 70 of about 7,550 (174)

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

High serum level of endostatin in multiple myeloma at diagnosis but not in the plateau phase after treatment

Mediators of Inflammation, 2003
We investigated the serum concentration of endostatin in 84 patients with multiple myeloma (MM) and in 13 healthy controls. The level of measured anti-angiogenic agent was correlated with the phase and stage of the disease, and most importantly with ...
Halina Urbanska-Rys, Tadeusz Robak
doaj   +1 more source

Endostatin's Antiangiogenic Signaling Network

Molecular Cell, 2004
It is here demonstrated that the set of gene expressions underlying the angiogenic balance in tissues can be molecularly reset en masse by a single protein. Using genome-wide expression profiling, coupled with RT-PCR and phosphorylation analysis, we show that the endogenous angiogenesis inhibitor endostatin downregulates many signaling pathways in ...
Abdollahi, Amir, Hahnfeldt, Philip, Maercker, Christian, Gröne, Hermann-Josef, Debus, Juergen, Ansorge, Wilhelm, Folkman, Judah, Hlatky, Lynn, Huber, Peter E   +8 more
openaire   +2 more sources

Preclinical and Virtual Models of Mucosal Melanoma: Bridging Translational Gaps in a Rare and Lethal Cancer

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
Integrated physical and virtual modeling provides a scalable framework to overcome sample scarcity, recapitulate mucosal melanoma biology, and accelerate translational discovery toward precision medicine. ABSTRACT Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct ...
Xiangjie Jin, Yuhan Zhang, Yuantai Zhu, Zhiyuan Zhang, Chaoji Shi   +4 more
wiley   +1 more source

Study the Association of Endostatin with some Anthropometric Measurements and Blood Pressure in Iraqi Women with Rheumatoid Arthritis [PDF]

مجلة جامعة الانبار للعلوم الصرفة
Autoimmune disorder, Rheumatoid arthritis (RA) which is most public disease that effected systems of the body and unknown etiology. RA is diagnosis by inflammation in the synovial joints mainly small joints and hyperplasia of synoviocytes causing erosion
Nusiba Alalwani, Shakir Alaaraji
doaj   +1 more source

Vascular endothelial growth factor, endostatin levels and clinical features among patients with ulcerative colitis and irritable bowel syndrome and among healthy controls: a cross-sectional analytical study

São Paulo Medical Journal
BACKGROUND: Increased angiogenetic activity in inflammatory bowel disease (IBD) has been shown in previous studies. The aim of this study was to evaluate the relationship of serum vascular endothelial growth factor (VEGF) and endostatin levels with ...
Evrim Kahramanoğlu Aksoy, Hülya Çetinkaya, Berna Savaş, Arzu Ensari, Murat Torgutalp, Cumali Efe   +5 more
doaj   +1 more source

Rh-endostatin Concomitant with Chemotherapy Versus Single Agent Chemotherapy for Treating Soft Tissue and Bone Sarcomas: A Systematic Review and Meta-Analysis

Journal of Pharmacy & Pharmaceutical Sciences, 2018
Objectives: Endostar (recombinant human endostatin (rh-endostatin)), a 20-kDa proteolytic fragment of collagen XVIII, was approved for the treatment of non–small cell lung cancer (NSCLC).
Zhuo Ma, Lifang Guo, Xiangli Cui, He Liu, Lihong Liu   +4 more
doaj   +1 more source

Elevated endostatin is associated with hypertension treatment, elevated high sensitivity C-reactive protein, increased waist-hip ratio, and attenuated kidney function, but not with age, in a middle-aged population

Global Cardiology
Circulating endostatin has been linked to increased mortality, cardiovascular comorbidities, and renal impairment. However, its role as a cardiovascular risk marker in the general population remains largely unexplored.
Anders Larsson, Bertil Wegmann, Toralph Ruge, Joakim Alfredsson, Carl Johan Östgren, Tomas Lindahl   +5 more
doaj   +1 more source