Results 71 to 80 of about 7,550 (174)

The Effect of Endostatin and Radiotherapy on Human Lung Cancer Cell Line A549 and the Impact of HIF-1 Expression after Therapy

Chinese Journal of Lung Cancer, 2009
Background and objective It has been proven that radiotherapy can induce tumor cells over expressing HIF-1. The aim of this work is to investigate the effect of endostatin and radiotherapy on human lung cancer cell line A549 and the impact of HIF-1 ...
Yanyan ZHANG, Wei GE, Juan ZHAO, Zhenyu ZHAO, Changhu LI   +4 more
doaj  

Difference in Serum Endostatin Levels in Diabetic Patients with Critical Limb Ischemia Treated by Autologous Cell Therapy or Percutaneous Transluminal Angioplasty

Cell Transplantation, 2018
The aim of this study was to compare the serum levels of the anti-angiogenic factor endostatin (S-endostatin) as a potential marker of vasculogenesis after autologous cell therapy (ACT) versus percutaneous transluminal angioplasty (PTA) in diabetic ...
Andrea Nemcova, Alexandra Jirkovska, Michal Dubsky, Libor Kolesar, Robert Bem, Vladimira Fejfarova, Anna Pysna, Veronika Woskova, Jelena Skibova, Edward B. Jude   +9 more
doaj   +1 more source

Pericardial Fluid and Serum Levels of Vascular Endothelial Growth Factor and Endostatin in Patients With or Without Coronary Artery Disease

Journal of the Formosan Medical Association, 2006
Vascular endothelial growth factor (VEGF) and endostatin are related to ischemic heart disease. This study investigated pericardial fluid and serum levels of VEGF and endostatin in patients with or without ischemic heart disease.
Jer-Young Liou, Pei-Liang Kuan
doaj   +1 more source

Effect of endostatin overexpression on angiotensin II-induced cardiac hypertrophy in rats

Chinese Medical Journal, 2019
. Background:. Endostatin, a biologically active fragment of collagen XVIII, has been observed in patients with ischemic heart disease. The aim of the present study was to investigate whether endostatin overexpression could attenuate cardiac hypertrophy ...
You-Jin Dai, Jue-Xiao Gong, Rong Bian, Yuan-Yuan Ji   +3 more
doaj   +1 more source

E-M, an Engineered Endostatin with High ATPase Activity, Inhibits the Recruitment and Alternative Activation of Macrophages in Non-small Cell Lung Cancer

Frontiers in Pharmacology, 2017
Endostatin recently was reported by our laboratory to possess ATPase activity that is indispensable for its anti-angiogenesis and anti-tumor effects. An engineered endostatin, E-M, which owns higher ATPase activity exhibits stronger inhibitory effects on
Min Xu, Min Xu, Min Xu, Shaosen Zhang, Shaosen Zhang, Shaosen Zhang, Lin Jia, Lin Jia, Lin Jia, Shan Wang, Shan Wang, Shan Wang, Jie Liu, Jie Liu, Jie Liu, Xuhui Ma, Xuhui Ma, Xuhui Ma, Chunying Wang, Chunying Wang, Chunying Wang, Yan Fu, Yan Fu, Yan Fu, Yongzhang Luo, Yongzhang Luo, Yongzhang Luo   +26 more
doaj   +1 more source

The Association between Serum Endostatin, Kidney Disease Progression, and Mortality in Patients with Chronic Kidney Disease in the Salford Kidney Study

Pulse
Introduction: Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular morbidity. Circulating endostatin is associated with both cardiovascular morbidity and impaired kidney function in the general population, but ...
Johanna Helmersson-Karlqvist, Rajkumar Chinnadurai, Per Wändell, Axel Carl Carlsson, Philip A. Kalra, Anders Olof Larsson, Tobias Feldreich, Johan Ärnlöv, Toralph Ruge   +8 more
doaj   +1 more source

携带Egr-1启动子和Endostatin基因的腺病毒穿梭质粒构建及鉴定

Zhongguo shiyan zhenduanxue, 2008
目的构建含辐射敏感启动子Egr-1和人内皮抑素（endostatin）基因的腺病毒穿梭质粒pshuttle-Egr1-Endostatin。方法利用RT-PCR方法从人胎肝中扩增出人endostatin cDNA序列,从T-Egr1质粒中扩增出Egr-1基因序列,并将它们连接到pMD19T质粒进行测序,利用基因重组技术构建含有辐射诱导启动子Egr-1的腺病毒穿梭质粒pshuttle-Egr1-Endostatin。结果经测序证实,获得的人endostatin基因和Egr ...
李艳博, 郭彩霞, 梁硕, 王志成, 康顺爱, 王剑锋, 龚守良   +6 more
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Role of Endostatin in Cardiovascular Remodeling

Circulation Journal, 2010
umor growth is accompanied by angiogenesis, and because surgical removal of certain tumors may lead to rapid growth of remote metastases, endogenous angiogenesis inhibitors may be secreted from the tumor. The endogenous angiogenesis inhibitor, angiostatin, was identified in urine in 1994, and a more potent angiogenesis inhibitor, endostatin, was ...
openaire   +3 more sources

Comparative study of endostatin levels in preeclampsia pregnancy and normal pregnancy

The Journal of Maternal-Fetal & Neonatal Medicine
Objective The primary objective was to compare endostatin levels between patients with preeclampsia and those with normal pregnancies. The secondary objectives comprised comparing endostatin levels in early-onset preeclampsia, late-onset preeclampsia ...
Chatprateep Poosawang, Vorapong Phupong
doaj   +1 more source

Generation and utilization of endostatin‐sensitive cell lines for assessing the biological activity of endostatin

MedComm
AbstractRecombinant proteins are gaining increasing popularity for treating human diseases. The clinical effectiveness of recombinant proteins is directly related to their biological activity, which is an important indicator in drug development and quality control.
Xi Qin, Yifang An, Xiang Li, Fang Huang, Yong Zhou, Dening Pei, Hua Bi, Xinchang Shi, Wenhong Fan, Youxue Ding, Shuang Li, Shanhu Li, Junzhi Wang   +12 more
openaire   +3 more sources