Results 71 to 80 of about 14,946 (225)

Risk Factors and Comparative Safety of Anti‐PD‐1 Combination Therapies in Advanced Melanoma: A Nationwide Real‐World Cohort Study From China

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Backgroud Different anti‐PD‐1 combination therapies are used to improve response rate and combat drug resistance for melanoma in the real world of China. While the reported safety data has remained scarce, especially for the controversial use of interferon.
Yuan Qiao, Xiao Fu, Sundus Shukar, Weihong Ge, Wei Yang, Ren bin Jiang, Xiaoyan Dai, Haisheng Chen, Jinyi Zhao, Meng Tang, Fei Mu, Hao Wang, Qiuhui Wu, Xing Xia, Yunan Zhang, Suzhi Ji, Ying Xu, Ruixin Cao, Jiexin Wang, Yu Yao, Jingwen Wang, Yu Fang   +21 more
wiley   +1 more source

Angiopoietin-2 predicts morbidity in adults with Fontan physiology. [PDF]

, 2019
Morbidity in patients with single-ventricle Fontan circulation is common and includes arrhythmias, edema, and pulmonary arteriovenous malformations (PAVM) among others. We sought to identify biomarkers that may predict such complications.
Aboulhosn, Jamil A, Boström, Kristina I, Conrad, Miles B, Guihard, Pierre J, Iruela-Arispe, M Luisa, Kim, Helen, Lluri, Gentian, Pawlikowska, Ludmila, Shirali, Aditya S   +8 more
core  

Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells [PDF]

, 2013
Background: The studies reported herein were undertaken to determine if the angiostatic function of p53 could be exploited as an adjunct to VEGF-targeted therapy in the treatment of renal cell carcinoma (RCC).
Geissler, Andrew K, Liu, Qingjun, Mier, James W., Panka, David Joel   +3 more
core   +1 more source

Unraveling the mysteries of endostatin [PDF]

IUBMB Life, 2009
AbstractEndostatin, a 20‐kDa C‐terminal proteolytic fragment of collagen XVIII, is a specific endogenous angiogenesis inhibitor discovered more than a decade. The structure, stability, and mechanism of actions of endostatin have been extensively investigated during the past 12 years, among which controversial reports remain unclarified.
Yan, Fu, Huadong, Tang, Yujie, Huang, Nan, Song, Yongzhang, Luo   +4 more
openaire   +2 more sources

Linking Antibody Fc Domain to Endostatin Significantly Improves Endostatin Half-life and Efficacy [PDF]

Clinical Cancer Research, 2008
Abstract Purpose: The half-life of the antiangiogenic molecule endostatin that has been used in clinical trial is short (∼2 h). In addition, ∼50% of the clinical grade endostatin molecules lack four amino acids at their NH2 termini. Lack of these amino acids gives rise to a molecule that is devoid of zinc, resulting in no antitumor ...
Tong-Young, Lee, Robert M, Tjin Tham Sjin, Shahla, Movahedi, Bissan, Ahmed, Elke A, Pravda, Kin-Ming, Lo, Stephen D, Gillies, Judah, Folkman, Kashi, Javaherian   +8 more
openaire   +2 more sources

Pushing Frontiers for Proteoglycans

Proteoglycan Research, Volume 4, Issue 2, April 2026.
ABSTRACT Almost half of proteins have one or more post‐translational glycosylation modifications involving the addition of glycan structures. Proteoglycans are a class of glycosylated proteins with one or more glycosaminoglycan (GAG) chains covalently attached to the core protein.
Marissa L. Maciej‐Hulme
wiley   +1 more source

Rh-endostatin Concomitant with Chemotherapy Versus Single Agent Chemotherapy for Treating Soft Tissue and Bone Sarcomas: A Systematic Review and Meta-Analysis

Journal of Pharmacy & Pharmaceutical Sciences, 2018
Objectives: Endostar (recombinant human endostatin (rh-endostatin)), a 20-kDa proteolytic fragment of collagen XVIII, was approved for the treatment of non–small cell lung cancer (NSCLC).
Zhuo Ma, Lifang Guo, Xiangli Cui, He Liu, Lihong Liu   +4 more
doaj   +1 more source

Antiangiogenesis: current clinical data and future perspectives [PDF]

, 2002
Neovascularization is a prerequisite for progressive growth of solid tumors and their metastases. This process is tightly regulated by a large number of proangiogenic and antiangiogenic factors such as VEGF, bFGF and matrix-metalloproteinases.
Drevs, J., Laus, C., Medinger, M., Schmidt-Gersbach, C., Unger, C.   +4 more
core   +1 more source

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Haijiang Wang, Xinxin Liu, Gido Gravesteijn, Alessia Atella, Jin Liu, Julie W. Rutten, Peter ten Dijke, Manuel A. F. V. Gonçalves, Saskia A. J. Lesnik Oberstein, David A. Baker   +9 more
wiley   +1 more source

Elevated endostatin is associated with hypertension treatment, elevated high sensitivity C-reactive protein, increased waist-hip ratio, and attenuated kidney function, but not with age, in a middle-aged population

Global Cardiology
Circulating endostatin has been linked to increased mortality, cardiovascular comorbidities, and renal impairment. However, its role as a cardiovascular risk marker in the general population remains largely unexplored.
Anders Larsson, Bertil Wegmann, Toralph Ruge, Joakim Alfredsson, Carl Johan Östgren, Tomas Lindahl   +5 more
doaj   +1 more source