Results 21 to 30 of about 206,338 (257)
Frontiers in Oncology, 2022 Lung cancer growth is dependent on angiogenesis. In recent years, angiogenesis inhibitors have attracted more and more attention as potential lung cancer treatments. Current anti-angiogenic drugs targeting VEGF or receptor tyrosine kinases mainly inhibit
Yingying Li +5 more
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Angiogenesis, Thrombospondin-1 and Cervical Carcinogenesis
Taiwanese Journal of Obstetrics & Gynecology, 2005 Angiogenesis, the growth of new vessels from existing vasculature, plays an essential role in tumor development. The process involves interaction among cancer cells, endothelial cells, and components of the extracellular matrix, and is regulated by the ...
Ming-Ping Wu, Cheng-Yang Chou
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Angiogenesis at the Interface between Basic and Clinical Research
The International Journal of Biological Markers, 1999 The field of antiangiogenesis has shown a remarkably rapid evolution from the discovery at the bench to translation into the clinic. Currently a wide variety of compounds are in clinical trial as inhibitors of angiogenesis, and new compounds are being ...
A. Albini, D. Noonan, L. Santi
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Anti-angiogenesis in prostate cancer: knocked down but not out
Asian Journal of Andrology, 2014 Angiogenesis is a very complex physiological process, which involves multiple pathways that are dependent on the homeostatic balance between the growth factors (stimulators and inhibitors).
Marijo Bilusic, Yu-Ning Wong
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Scientific Reports, 2023 Tumor-associated high endothelial venules (TA-HEVs) mediate lymphocyte entry into tumors. Therefore, combined anti-angiogenesis therapy and programmed death-1 (PD-1) inhibitors might stimulate tumor immunity.
Dafu Ye +6 more
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Endogenous Matrix-Derived Inhibitors of Angiogenesis
Pharmaceuticals, 2010 Endogenous inhibitors of angiogenesis are proteins or fragments of proteins that are formed in the body, which can inhibit the angiogenic process. These molecules can be found both in the circulation and sequestered in the extracellular matrix (ECM ...
Hans Petter Eikesdal +2 more
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PLoS ONE, 2016 BackgroundCurrently, the standard treatment for newly diagnosed glioblastoma multiforme (GBM) is maximal safe surgical resection followed by radiation therapy with concurrent and adjuvant temozolomide.
Yawei Wang +4 more
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Endogenous inhibitors of angiogenesis [PDF]
Journal of Cell Science, 2001 In the course of embryonic development, during some normal physiological processes in the adult, such as the female reproductive cycle, and also in a variety of pathologies, including tumour growth, new blood vessels develop from the pre-existing vascular network through endothelial cell sprouting,
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Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]
PLoS ONE, 2013 Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Sabine B Weitensteiner +8 more
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