Results 211 to 220 of about 206,338 (257)
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Clinical and Translational Oncology, 2006
Angiogenesis and neovascularization are important mechanisms for tumor growth, progression and, subsequent metastasis. Cancer cells, as part of an inflammatory process, produce and induce multiple molecules (proangiogenic and antiangiogenic) from the surrounding stromal cells. Vascular Endothelial Growth Factor (VEGF) is the most relevant proangiogenic
V, Almendro, P, Gascón
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Angiogenesis and neovascularization are important mechanisms for tumor growth, progression and, subsequent metastasis. Cancer cells, as part of an inflammatory process, produce and induce multiple molecules (proangiogenic and antiangiogenic) from the surrounding stromal cells. Vascular Endothelial Growth Factor (VEGF) is the most relevant proangiogenic
V, Almendro, P, Gascón
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Current Oncology Reports, 2000
Angiogenesis inhibitors target the neovascular development that is hypothesized to underlie tumor growth. The inhibitors that are undergoing the clinical testing phase can be divided into five categories based on their target activity: 1) drugs that block matrix breakdown; 2) drugs that inhibit endothelial cells directly; 3) drugs that block ...
T R, Tennant +2 more
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Angiogenesis inhibitors target the neovascular development that is hypothesized to underlie tumor growth. The inhibitors that are undergoing the clinical testing phase can be divided into five categories based on their target activity: 1) drugs that block matrix breakdown; 2) drugs that inhibit endothelial cells directly; 3) drugs that block ...
T R, Tennant +2 more
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Src Inhibitors and Angiogenesis
Current Pharmaceutical Design, 2007Angiogenesis is a tightly regulated process that leads to the formation of new blood vessels in limited physiological conditions, and can also occur under pathological situations as retinopathies, arthritis, endometriosis and cancer. Enhanced angiogenesis is present in tumors that need new blood capillaries to grow, remove metabolic waste and transport
SCHENONE S +2 more
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Protamine is an inhibitor of angiogenesis
Nature, 1982Protamine is shown to be a specific inhibitor of angiogenesis. The compound inhibits the capillary proliferation observed in embryogenesis, inflammation, certain immune reactions and the growth of solid tumours.
S, Taylor, J, Folkman
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2015
Angiogenesis plays a pivotal role in malignant, ischemic, inflammatory, infectious and immune disorders. The increasing molecular understanding of angiogenic processes fostered the development of strategies to induce or inhibit angiogenesis for therapeutic purposes.
H, Büning, U T, Hacker
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Angiogenesis plays a pivotal role in malignant, ischemic, inflammatory, infectious and immune disorders. The increasing molecular understanding of angiogenic processes fostered the development of strategies to induce or inhibit angiogenesis for therapeutic purposes.
H, Büning, U T, Hacker
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Endogenous Inhibitors of Angiogenesis
Cancer Research, 2005Abstract Angiogenesis, the formation of new blood vessels, is required for many pathologic processes, including invasive tumor growth as well as physiologic organ/tissue maintenance. Angiogenesis during development and adulthood is likely regulated by a balance between endogenous proangiogenic and antiangiogenic factors. It is speculated
Pia, Nyberg, Liang, Xie, Raghu, Kalluri
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Update on angiogenesis inhibitors
Current Opinion in Oncology, 2005A number of therapeutic agents have been developed which have anti-angiogenic potential. Here we present the most recent data from clinical trials with some of the promising inhibitors of angiogenesis.Agents that target the vascular endothelial growth factor signaling pathway are the furthest along in clinical development.
Anaadriana, Zakarija, Gerald, Soff
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Emoxypine as an inhibitor of angiogenesis
Bulletin of Experimental Biology and Medicine, 1992The effect of emoxypin on angiogenesis in rabbit cornea in aseptic inflammation induced by intracorneal implantation of a piece of quartz and on the development of the vessels of the chick embryo yolk sac was studied. 1% emoxypin pipetted thrice a day for 10-14 days inhibited corneal neovascularization and reduced the formation of new blood vessels. We
A A, Sologub +2 more
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Biochemistry (Moscow), 2003
Formation of the blood supply system is a critical step in malignant transformation of neoplasms which results in the penetration of tumor cells into neighboring tissues and metastatic growth. Significant progress in the elucidation of mechanisms underlying tumor angiogenesis and the discovery of a great diversity of biomolecules involved in its ...
S M, Kiselev +3 more
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Formation of the blood supply system is a critical step in malignant transformation of neoplasms which results in the penetration of tumor cells into neighboring tissues and metastatic growth. Significant progress in the elucidation of mechanisms underlying tumor angiogenesis and the discovery of a great diversity of biomolecules involved in its ...
S M, Kiselev +3 more
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Maspin is an angiogenesis inhibitor
Nature Medicine, 2000Maspin, a unique member of the serpin family, is a secreted protein encoded by a class II tumor suppressor gene whose downregulation is associated with the development of breast and prostate cancers. Overexpression of maspin in breast tumor cells limits their growth and metastases in vivo.
M, Zhang, O, Volpert, Y H, Shi, N, Bouck
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