Results 21 to 30 of about 322,587 (327)
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells [PDF]
, 2016 Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and ...
Carrasco-Avino, G +4 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 Aberrant regulation of angiogenesis involves in the growth and metastasis of tumors, but angiogenesis inhibitors fail to improve overall survival of pancreatic cancer patients in previous phase III clinical trials.
Xi Zhang +7 more
doaj +1 more source
Role of mTOR signaling in tumor microenvironment. An overview [PDF]
, 2018 The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara +8 more
core +2 more sources
Frontiers in Immunology, 2022 Angiogenesis in metastatic castration-resistant prostate cancer (mCRPC) has been extensively investigated as a promising druggable biological process. Nonetheless, targeting angiogenesis has failed to impact overall survival (OS) in patients with mCRPC ...
Antonio Giovanni Solimando +4 more
doaj +1 more source
Temporal and spatial expression of tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and -2) in the bovine corpus luteum [PDF]
, 2003 The matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), may mediate the dramatic structural and functional changes in the corpus luteum (CL) over the course of its life span.
Moses, Marsha A. +2 more
core +3 more sources
Bioinformatic Analysis for the Validation of Novel Biomarkers for Cancer Diagnosis and Drug Sensitivity [PDF]
, 2015 Background: The genetic control of tumour progression presents the opportunity for bioinformatics and gene expression data to be used as a basis for tumour grading.
Lockwood, Laura Anne Rebecca
core +2 more sources
Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases
Frontiers in Immunology, 2019 Angiogenesis is facilitated by the proteolytic activities of members of the matrix metalloproteinase (MMP) family. More specifically, MMP-9 and MT1-MMP directly regulate angiogenesis, while several studies indicate a role for MMP-2 as well.
Gregg B. Fields, Gregg B. Fields
doaj +1 more source
Characterization of small molecules inhibiting the pro-angiogenic activity of the zinc finger transcription factor Vezf1 [PDF]
, 2018 Discovery of inhibitors for endothelial-related transcription factors can contribute to the development of anti-angiogenic therapies that treat various diseases, including cancer.
Gowher, Humaira +4 more
core +2 more sources
Angiogenesis Inhibitors in NSCLC. [PDF]
Int J Mol Sci, 2017 Angiogenesis is a complex biological process that plays a relevant role in sustaining the microenvironment, growth, and metastatic potential of several tumors, including non-small cell lung cancer (NSCLC). Bevacizumab was the first angiogenesis inhibitor approved for the treatment of patients with advanced NSCLC in combination with chemotherapy ...
Manzo A +10 more
europepmc +4 more sources
Frontiers in Oncology, 2022 Lung cancer growth is dependent on angiogenesis. In recent years, angiogenesis inhibitors have attracted more and more attention as potential lung cancer treatments. Current anti-angiogenic drugs targeting VEGF or receptor tyrosine kinases mainly inhibit
Yingying Li +5 more
doaj +1 more source