Results 21 to 30 of about 196,511 (287)
Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases
Frontiers in Immunology, 2019 Angiogenesis is facilitated by the proteolytic activities of members of the matrix metalloproteinase (MMP) family. More specifically, MMP-9 and MT1-MMP directly regulate angiogenesis, while several studies indicate a role for MMP-2 as well.
Gregg B. Fields, Gregg B. Fields
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Frontiers in Oncology, 2022 Lung cancer growth is dependent on angiogenesis. In recent years, angiogenesis inhibitors have attracted more and more attention as potential lung cancer treatments. Current anti-angiogenic drugs targeting VEGF or receptor tyrosine kinases mainly inhibit
Yingying Li +5 more
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Angiogenesis, Thrombospondin-1 and Cervical Carcinogenesis
Taiwanese Journal of Obstetrics & Gynecology, 2005 Angiogenesis, the growth of new vessels from existing vasculature, plays an essential role in tumor development. The process involves interaction among cancer cells, endothelial cells, and components of the extracellular matrix, and is regulated by the ...
Ming-Ping Wu, Cheng-Yang Chou
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Anti-angiogenesis in prostate cancer: knocked down but not out
Asian Journal of Andrology, 2014 Angiogenesis is a very complex physiological process, which involves multiple pathways that are dependent on the homeostatic balance between the growth factors (stimulators and inhibitors).
Marijo Bilusic, Yu-Ning Wong
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Scientific Reports, 2023 Tumor-associated high endothelial venules (TA-HEVs) mediate lymphocyte entry into tumors. Therefore, combined anti-angiogenesis therapy and programmed death-1 (PD-1) inhibitors might stimulate tumor immunity.
Dafu Ye +6 more
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Angiogenesis and angiogenesis inhibitors in paediatric diseases
European Journal of Pediatrics, 1992 Angiogenesis, the generation of new capillaries from existing blood vessels, is rarely observed in the healthy organism, but can present during various paediatric diseases. In this review, we describe recent progress in the understanding of pathological angiogenesis and approaches for an improved therapy of angiogenic childhood diseases.
Schweigerer, L., Fotsis, T.
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Endogenous Matrix-Derived Inhibitors of Angiogenesis
Pharmaceuticals, 2010 Endogenous inhibitors of angiogenesis are proteins or fragments of proteins that are formed in the body, which can inhibit the angiogenic process. These molecules can be found both in the circulation and sequestered in the extracellular matrix (ECM ...
Hans Petter Eikesdal +2 more
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PLoS ONE, 2016 BackgroundCurrently, the standard treatment for newly diagnosed glioblastoma multiforme (GBM) is maximal safe surgical resection followed by radiation therapy with concurrent and adjuvant temozolomide.
Yawei Wang +4 more
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Metalloproteinases and their inhibitors in tumor angiogenesis [PDF]
International Journal of Cancer, 2005 AbstractAngiogenesis is the process by which new blood vessels are formed from preexisting vasculature. It is an essential feature of the female reproductive cycle, embryonic development and wound repair. Angiogenesis has also been identified as a causal or contributing factor in several pathologies, including cancer, where it is a rate‐limiting step ...
Handsley, M.M., Edwards, D.R.
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Irsogladine is a potent inhibitor of angiogenesis [PDF]
FEBS Letters, 1993 We describe a novel inhibitor of angiogenesis, Irsogladine, an anti‐ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF.
Kazuki Okamura +7 more
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