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Endogenous Inhibitors of Angiogenesis [PDF]

Cancer Research, 2005
Abstract Angiogenesis, the formation of new blood vessels, is required for many pathologic processes, including invasive tumor growth as well as physiologic organ/tissue maintenance. Angiogenesis during development and adulthood is likely regulated by a balance between endogenous proangiogenic and antiangiogenic factors. It is speculated
Pia Nyberg, Raghu Kalluri, Liang Xie
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Inhibitors of Angiogenesis

2015
Angiogenesis plays a pivotal role in malignant, ischemic, inflammatory, infectious and immune disorders. The increasing molecular understanding of angiogenic processes fostered the development of strategies to induce or inhibit angiogenesis for therapeutic purposes.
H. Büning, U. T. Hacker
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Endogenous angiogenesis inhibitors [PDF]

APMIS, 2004
When the FDA commissioner announced in February 2004 the approval of Avastin for the treatment of patients with colon cancer, he called angiogenesis inhibitors a fourth modality of anti‐cancer therapy. Because angiogenesis inhibitors are relatively less toxic than conventional chemotherapy and have a lower risk of drug resistance, they may also ...
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Angiogenesis Inhibitors: Current Strategies and Future Prospects

Ca-A Cancer Journal for Clinicians, 2010
Angiogenesis has become an attractive target for drug therapy because of its key role in tumor growth. An extensive array of compounds is currently in preclinical development, with many now entering the clinic and/or achieving approval from the US Food ...
Kristina M Cook, William D Figg
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Protamine is an inhibitor of angiogenesis

Nature, 1982
Protamine is shown to be a specific inhibitor of angiogenesis. The compound inhibits the capillary proliferation observed in embryogenesis, inflammation, certain immune reactions and the growth of solid tumours.
Judah Folkman, Stephanie Taylor
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Update on angiogenesis inhibitors

Current Opinion in Oncology, 2005
A number of therapeutic agents have been developed which have anti-angiogenic potential. Here we present the most recent data from clinical trials with some of the promising inhibitors of angiogenesis.Agents that target the vascular endothelial growth factor signaling pathway are the furthest along in clinical development.
Gerald A. Soff, Anaadriana Zakarija
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Inhibitors of Tumor Angiogenesis

2008
Inhibitors of Tumor ...
Harris, Adrian L, GENERALI, DANIELE
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Maspin is an angiogenesis inhibitor

Nature Medicine, 2000
Maspin, a unique member of the serpin family, is a secreted protein encoded by a class II tumor suppressor gene whose downregulation is associated with the development of breast and prostate cancers. Overexpression of maspin in breast tumor cells limits their growth and metastases in vivo.
Olga V. Volpert, Yihui H. Shi, Noel P. Bouck, Ming Zhang   +3 more
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Emoxypine as an inhibitor of angiogenesis

Bulletin of Experimental Biology and Medicine, 1992
The effect of emoxypin on angiogenesis in rabbit cornea in aseptic inflammation induced by intracorneal implantation of a piece of quartz and on the development of the vessels of the chick embryo yolk sac was studied. 1% emoxypin pipetted thrice a day for 10-14 days inhibited corneal neovascularization and reduced the formation of new blood vessels. We
A. A. Sologub, G. G. Ziangirova, S. I. Akberova   +2 more
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Metalloproteinases and their inhibitors in angiogenesis

Expert Reviews in Molecular Medicine, 2003
Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is an integral part of physiological processes such as embryonic development, the female reproductive cycle and wound healing. Angiogenesis is also central to a variety of pathologies including cancer, where it is recognised as being crucial for the growth of solid ...
Lafleur, M.A., Handsley, M.M., Edwards, D.R.   +2 more
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