Results 361 to 370 of about 3,183,533 (410)

Heparin Derivatives as Angiogenesis Inhibitors

Current Pharmaceutical Design, 2003
Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell proliferation is observed in tumor neovascularization and in angioproliferative diseases. Tumors cannot growth as a mass above few mm(3) unless a new blood supply is induced. It derives that the control of the neovascularization process may affect tumor
PRESTA, Marco, LEALI, Daria, STABILE H., RONCA, Roberto, CAMOZZI M., COCO L., MORONI E., LIEKENS S., RUSNATI, Marco   +8 more
openaire   +3 more sources

Thrombospondin as an Inhibitor of Angiogenesis [PDF]

, 1999
Most normal, healthy adult tissues exist in a state of vascular quiescence that is sustained by a combination of influences that include embryonic factors (1), associated cells (2) and an overall balance of angiogenic factors in which inhibitors predominate over inducers (3).
Noel P. Bouck, David W. Dawson
openaire   +1 more source

CURCUMIN AS AN INHIBITOR OF ANGIOGENESIS

2007
Angiogenesis, the formation of new blood vessels from host vasculature, is critical for tumor growth and metastases. -Curcumin, a novel small-molecular-weight compound, has been shown to inhibit carcinogenesis in different organs and the common link between these actions is its antiangiogenic effect.
Sulochana S. Bhandarkar, Jack L. Arbiser
openaire   +2 more sources

Perillyl Alcohol Is an Angiogenesis Inhibitor [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2004
Aberrant angiogenesis is essential for the progression of solid tumors and hematological malignancies. Thus, antiangiogenic therapy is one of the most promising approaches to control cancer. In the present work, we examined the ability of perillyl alcohol (POH), a dietary monoterpene with well-established tumor chemopreventive and chemotherapeutic ...
Vassoula Skouridou, Evangelia Papadimitriou, Andreas Papapetropoulos, Charis Roussos, Fragiskos N. Kolisis, Heleni Loutrari, Maria Hatziapostolou   +6 more
openaire   +2 more sources

Tumor angiogenesis inhibitors.

Biochemistry. Biokhimiia, 2003
Formation of the blood supply system is a critical step in malignant transformation of neoplasms which results in the penetration of tumor cells into neighboring tissues and metastatic growth. Significant progress in the elucidation of mechanisms underlying tumor angiogenesis and the discovery of a great diversity of biomolecules involved in its ...
Severin Se, S. M. Kiselev, E S Severin, Sergey V. Lutsenko   +3 more
openaire   +2 more sources

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice.

Science, 1999
Solid tumors depend on angiogenesis for their growth. In a transgenic mouse model of pancreatic islet cell carcinogenesis (RIP1-Tag2), an angiogenic switch occurs in premalignant lesions, and angiogenesis persists during progression to expansive solid ...
G. Bergers, K. Javaherian, K. Lo, J. Folkman, D. Hanahan   +4 more
semanticscholar   +1 more source

A diaminoantraquinone inhibitor of angiogenesis.

The Journal of Pharmacology and Experimental Therapeutics, 1994
Tumor growth is dependent upon angiogenesis. There is an intense search for pharmacological inhibitors of angiogenesis as a novel approach to treat angiogenic diseases, e.g., arthritis, diabetic retinopathy or cancer. A series of compounds, originally studied as potential protein kinase C inhibitors, included the diaminoanthraquinone NSC 639366 (1-[[3-(
S, Takano, S, Gately, J B, Jiang, S, Brem   +3 more
openaire   +2 more sources

Cytokine and Angiogenesis Inhibitors

2005
Renal cell carcinoma is an important malignancy accounting for approximately 3% of all adult cancers [1]. The incidence of renal cell carcinoma has been steadily and significantly increasing over the past two decades, with worldwide mortality expected to exceed 100,000 [2].
Timothy G. Eisen, Simon Chowdhury, Martin Gore   +2 more
openaire   +2 more sources

[Dermatologic side effects induced by new angiogenesis inhibitors].

Bulletin du Cancer, 2011
While new anticancer angiogenesis inhibitors present a well-tolerated safety profile, they are not without adverse events. The signaling pathways and/or receptors inhibited by these new drugs are often physiologically expressed in the skin and/or hair ...
V. Sibaud, I. Garrido-Stowhas, Ewa Cottura, C. Chevreau   +3 more
semanticscholar   +1 more source

Angiogenesis inhibitors and their delivery systems

Applied Biochemistry and Biotechnology, 1983
The extensive vascularity of solid tumors has been recognized for over 100 yr (1). However, only in the past 15 yr has the importance of this phenomenon been appreciated and only in the past 6 yr has the possibility of chemical interference been apparent. In this article, we review the emerging field of tumor vascularization inhibitors.
Robert Langer, Robert Langer, Joanne Murray, Joanne Murray   +3 more
openaire   +3 more sources