Results 41 to 50 of about 16,714,816 (218)

Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4

Journal of Lipid Research, 2004
Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to increase plasma triglyceride (TG) levels in vivo.
Hongfei Ge, Guoqing Yang, Xinxin Yu, Tiffany Pourbahrami, Cai Li   +4 more
doaj   +1 more source

The effect of three acid-resistant isolated proteins from Lactobacillus casei on lipid and carbohydrate metabolism pathway-related genes: An In vitro study

Biomedical and Biotechnology Research Journal, 2021
Background: The role of Lactobacillus casei on human health is well documented. However, little is known about their protein effects on food digestion. Therefore, in the present study, we aimed to investigate the efficacy of three proteins of L. casei on
Golgis Karimi, Mina Saadat, Shivasadat Gheflat, Bahram Kazemi, Mojgan Bandehpour   +4 more
doaj   +1 more source

Relationship between serum angiopoietin-like 4 levels and recurrence of atrial fibrillation

Journal of International Medical Research, 2021
Objective To investigate the association between serum angiopoietin-like 4 (ANGPTL4) levels and recurrence of atrial fibrillation (AF) after catheter ablation.
Zhongping Ning, Xinming Li, Xi Zhu, Jun Luo, Yingbiao Wu   +4 more
doaj   +1 more source

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice [PDF]

Proceedings of the National Academy of Sciences, 2007
We used gene knockout mice to explore the role of Angiopoietin-like-4 (Angptl4) in lipid metabolism as well as to generate anti-Angptl4 mAbs with pharmacological activity. Angptl4 −/− mice had lower triglyceride (TG) levels resulting both from increased very low-density lipoprotein (VLDL) clearance and decreased VLDL production and had modestly lower ...
Urvi, Desai, E-Chiang, Lee, Kyu, Chung, Cuihua, Gao, Jason, Gay, Billie, Key, Gwenn, Hansen, Dennis, Machajewski, Kenneth A, Platt, Arthur T, Sands, Matthias, Schneider, Isaac, Van Sligtenhorst, Adisak, Suwanichkul, Peter, Vogel, Nat, Wilganowski, June, Wingert, Brian P, Zambrowicz, Greg, Landes, David R, Powell   +18 more
openaire   +2 more sources

Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis.

, 2011
OBJECTIVE: To determine the utility of angiopoietin-1 and angiopoietin-2 as potentially novel biomarkers of morbidity and mortality in patients with severe sepsis. DESIGN: Multicenter longitudinal cohort study.
Hawkes, Michael, Michael Hawkes, Nimerta Rajwans, W. Conrad Liles, Fox-Robichaud, Alison, Lisa J. Toltl, Alison Fox-Robichaud, Patricia C. Liaw, Cook, Deborah J, Ricciuto, Daniel R, Lafferty, Erin I, Rajwans, Nimerta, Kain, Kevin C, Andrea L. Conroy, Kevin C. Kain, Conroy, Andrea L, Daniel R. Ricciuto, Deborah J. Cook, Kahnamoui, Kamyar, Erin I. Lafferty, dos Santos, Claudia C, Liaw, Patricia C, Liles, W Conrad, Kamyar Kahnamoui, Toltl, Lisa J, Claudia C. dos Santos   +25 more
core   +1 more source

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin

Journal of Lipid Research, 2014
Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis.
Taiyi Kuo, Tzu-Chieh Chen, Stephanie Yan, Fritz Foo, Cecilia Ching, Allison McQueen, Jen-Chywan Wang   +6 more
doaj   +1 more source

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

Journal of Lipid Research, 2016
LPL hydrolyzes triglycerides in triglyceride-rich lipoproteins along the capillaries of heart, skeletal muscle, and adipose tissue. The activity of LPL is repressed by angiopoietin-like 4 (ANGPTL4) but the underlying mechanisms have not been fully ...
Wieneke Dijk, Anne P. Beigneux, Mikael Larsson, André Bensadoun, Stephen G. Young, Sander Kersten   +5 more
doaj   +1 more source

A Review of free fatty acid-induced cell signaling, angiopoietin-like protein 4, and skeletal muscle differentiation

Frontiers in Physiology, 2022
Postnatal skeletal muscle differentiation from quiescent satellite cells is a highly regulated process, although our understanding of the contribution of nutritional factors in myogenesis is limited. Free fatty acids (FFAs) are known to cause detrimental
Yura Son, Chad M. Paton, Chad M. Paton
doaj   +1 more source

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

, 2003
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) have been identified as ligands with different effector functions of the vascular assembly and maturation-mediating receptor tyrosine kinase Tie-2.
Weiss, C, Koblizek, T., Marme, D., Augustin, HG, Augustin, H. G., Fiedler, U, Krissl, T., Martiny-Baron, G., Krissl, T, Koidl, S., Martiny-Baron, G, Deutsch, U, Fiedler, U., Weiss, C., Deutsch, U., Koidl, S, Koblizek, T, Marmé, D   +17 more
core   +1 more source

Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion [PDF]

, 2010
There is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth and differentiation. Recently, it has been reported that angiopoietin-like 4 (ANGPTL4) in cancer cell promotes the metastatic ...
Taguchi, Takashi, Hirakawa, Hiroshi, Nagayasu, Takeshi, Abe, Kuniko, Nakayama, Toshiyuki, Shibata, Kenichiro   +5 more
core