Results 111 to 120 of about 24,454,690 (224)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Serum Angiopoietin-like Protein 6, Risk of Type 2 Diabetes, and Response to Hyperglycemia: A Prospective Cohort Study. Supplementary Tables.

, 2020
Supplementary Tables for the manuscript "Serum Angiopoietin-like Protein 6, Risk of Type 2 Diabetes, and Response to Hyperglycemia: A Prospective Cohort Study".
Chih-Yao Hsu (8072330), Kang-Chih Fan (8072324), Hung-Tsung Wu (6942860), Lee-Ming Chuang (215892), Hung-Yuan Li (8375622), Jung-Nan Wei (662603), I-Weng Yen (8072321), Shu-Huei Wang (75251), Tien-Jyun Chang (438363), Mao-Shin Lin (309335), Shyang-Rong Shih (662601), Chia-Hung Lin (1998472)   +11 more
core   +1 more source

ANGPT2 Drives Thyroid Cancer Progression Through PI3K/AKT Signaling and Correlates With Poor Prognosis and Immune Infiltration

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Angiopoietin‐2 (ANGPT2) is known to participate in tumor progression and immune modulation across multiple malignancies. Nevertheless, its expression pattern, prognostic value, and biological function in thyroid cancer (THCA) have not been comprehensively investigated.
Han Chen, Lin Wang, Ji‐Sheng Zhang, Xu‐Dong Yan, Long‐Gang Yu, Yan Jiang   +5 more
wiley   +1 more source

Real‐World Safety and Effectiveness of Icatibant in Patients With Hereditary Angioedema (HAE): Post‐Marketing Surveillance in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Hereditary angioedema (HAE) is a rare, autosomal dominant, life‐threatening disease characterized by recurrent attacks of swelling of the face, upper airway, gastrointestinal tract, limbs, and/or genitalia. Genetic mutations of the SERPING1 gene encoding the C1‐inhibitor (C1‐INH) plasma protein are associated with HAE‐C1INH.
Kumiko Hosono, Miyako Hoshino
wiley   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion1[S]

Journal of Lipid Research, 2015
Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased ...
Yan Wang, Viktoria Gusarova, Serena Banfi, Jesper Gromada, Jonathan C. Cohen, Helen H. Hobbs   +5 more
doaj   +1 more source

Angiopoietin-like protein 2 and angiopoietin-like protein 6 levels in patients with nonalcoholic fatty liver disease [PDF]

, 2018
WOS: 000436361500010PubMed ID: 30002695Introduction: The aim of the current study was to examine the difference between patients detected with nonalcoholic fatty liver disease (NAFLD) and healthy subjects in terms of serum angiopoietin-like protein ...
Erkan, Gülbanu, Muratoglu, S., Bilgihan, Ayşe, Bilgihan, A., Muratoğlu, Suzan, Ercin, U., Erkan, G., Erçin, Uğur   +7 more
core   +1 more source

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

Plasma angiopoietin-like protein 4 as a novel biomarker predicting 10-year mortality in a community-based population: a longitudinal cohort study

Introduction Angiopoietin-like protein 4 (ANGPTL4) is a hepatokine implicated in fat metabolism regulation. Its genetic inactivation has been associated with improved glucose homeostasis, while elevated plasma ANGPTL4 levels are observed in diabetic and ...
Ya-Pin Lyu, Chun-Heng Kuo, Hsien-Chia Juan, Mao-Shin Lin, I-Weng Yen, Chia-Hung Lin, Kang-Chih Fan, Szu-Chi Chen, Shu-Huei Wang, Hung-Yuan Li   +9 more
core   +1 more source

Angiopoietin-Like Protein 1 Decreases Blood Brain Barrier Damage and Edema Following Focal Cerebral Ischemia in Mice

, 2011
Angiopoietin-like protein (Angptl) 1, a member of the angiopoietin- related protein family, modulates angiogenesis but little else is known of its physiological role.
LAI, DAR-MING;LI, HUNG;LEE, CHIN-CHENG;TZENG, YI-SHIUAN;HSU, WEN-MING;HSIEH, FON-JOU;CHENG, JUEI-TANG;TU, YONG-KWANG, 賴達明;李鴻;李進成;曾奕軒;許文明;謝豐舟;鄭瑞堂;杜永光   +1 more
core   +1 more source