Results 191 to 200 of about 94,755 (223)

Response of Angiopoietin-like Proteins 3 and 4 to Hemodialysis

The International Journal of Artificial Organs, 2014
Background/Aim Patients on chronic hemodialysis (cHD) have decreased activity of lipoprotein lipase (LPL). Angiopoietin-like proteins (ANGPTL) 3 and 4 have been shown to inactivate LPL. The aim of this study was to investigate the levels of the ANGPTLs in plasma of cHD-patients and to evaluate if cHD may alter ...
Dana, Mahmood, Elena, Makoveichuk, Solveig, Nilsson, Gunilla, Olivecrona, Bernd, Stegmayr   +4 more
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Serum angiopoietin-like protein 3 concentrations in rheumatic diseases

European Journal of Dermatology, 2012
Angiopoietin-like protein 3 (Angptl3) is one of the angiogenic cytokines that stimulates endothelial cell adhesion, migration, and neovascularization. No link has been established between Angptl3 and rheumatic diseases such as systemic sclerosis or dermatomyositis (DM).
Yasuyo, Hayashi, Masatoshi, Jinnin, Takamitsu, Makino, Ikko, Kajihara, Katsunari, Makino, Noritoshi, Honda, Wakana, Nakayama, Kuniko, Inoue, Satoshi, Fukushima, Hironobu, Ihn   +9 more
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Structure and Function of Angiopoietin-like Protein 3 (ANGPTL3) in Atherosclerosis

Current Medicinal Chemistry, 2020
Background: Angiopoietin-Like Proteins (ANGPTLs) are structurally related to the angiopoietins. A total of eight ANGPTLs (from ANGPTL1 to ANGPTL8) have been identified so far. Most ANGPTLs possess multibiological functions on lipid metabolism, atherosclerosis, and cancer.
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Genetics and regulation of angiopoietin-like proteins 3 and 4

Current Opinion in Lipidology, 2006
Lipoprotein lipase activity in a given tissue is the rate limiting step for the uptake of triglyceride-derived fatty acids. Imbalances in the partitioning of fatty acids have major metabolic consequences. Given the central role of lipoprotein lipase in energy metabolism, the discovery of new molecules that affect the activity of lipoprotein lipase ...
openaire   +2 more sources

Antibodies to human angiopoietin-like protein 3: a patent evaluation of WO2012174178

Expert Opinion on Therapeutic Patents, 2013
The patent WO2012174178 claims the effect of a fully human antibody or antigen-binding fragment of a human antibody which specifically binds and neutralizes, inhibits, blocks, abrogates, reduces or interferes with the activity of human angiopoietin-like protein 3 (hANGPTL3).
Katsuyuki, Nakajima, Junji, Kobayashi
openaire   +2 more sources

Inhibition of Angiopoietin-Like Protein 3 or 3/8 Complex and ApoC-III in Severe Hypertriglyceridemia

Current Atherosclerosis Reports, 2023
The role of the inhibition of ANGPTL3 in severe or refractory hypercholesterolemia is well documented, less in severe hyperTG. This review focuses on the preclinical and clinical development of ApoC-III inhibitors and ANGPTL3, 4, and 3/8 complex inhibitors for the treatment of severe or refractory forms of hypertriglyceridemia to prevent cardiovascular
Miriam, Larouche, Etienne, Khoury, Diane, Brisson, Daniel, Gaudet   +3 more
openaire   +2 more sources

Future of angiopoietin-like protein 3 inhibitors as a therapeutic agent

Current Opinion in Lipidology
Purpose of review Triglyceride-rich lipoproteins (TRLs) and LDL remain major drivers of atherosclerotic cardiovascular disease, and angiopoietin-like protein 3 (ANGPTL3) has emerged as a promising target to lower both triglycerides and LDL cholesterol (LDL-C).
Nicholas A, Marston, André, Zimerman
openaire   +2 more sources

Inhibition of angiopoietin-like protein 3 as a target for managing hypertriglyceridemia

Current Opinion in Endocrinology, Diabetes & Obesity
Purpose of review To summarize recent advances in therapeutic strategies targeting angiopoietin-like protein 3 (ANGPTL3), a central regulator of triglyceride and remnant lipoprotein metabolism, and to discuss the potential of emerging pharmacologic approaches
Pablo, Corral, Natalia, Nardelli, Laura, Schreier   +2 more
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Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes

Biochemical and Biophysical Research Communications, 2003
Our previous work identified a genetic mutation in the gene encoding angiopoietin-like protein 3 (Angptl3) in KK/Snk mice (previously KK/San), a mutant strain of KK obese mice. KK/Snk had significantly lower plasma triglyceride and free fatty acid (FFA) than KK mice. Human ANGPTL3 treatment increased both plasma triglyceride and FFA.
Mitsuru, Shimamura, Morihiro, Matsuda, Sachiko, Kobayashi, Yosuke, Ando, Mitsuru, Ono, Ryuta, Koishi, Hidehiko, Furukawa, Makoto, Makishima, Iichiro, Shimomura   +8 more
openaire   +2 more sources

Plasma angiopoietin-like protein 3 (ANGPTL3) concentration is associated with uremic dyslipidemia

Atherosclerosis, 2009
Angiopoietin-like protein 3, a liver-derived plasma protein, increases plasma triglycerides (TG) in mice by suppressing the activity of lipoprotein lipase, a key enzyme in plasma TG clearance. Uremic dyslipidemia is characterized by increased TG-rich lipoproteins such as very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL ...
Tetsuo, Shoji, Sawako, Hatsuda, Shoko, Tsuchikura, Eiji, Kimoto, Ryusuke, Kakiya, Hideki, Tahara, Hidenori, Koyama, Masanori, Emoto, Tsutomu, Tabata, Yoshiki, Nishizawa   +9 more
openaire   +2 more sources