Results 251 to 260 of about 57,083 (310)
Some of the next articles are maybe not open access.
Angiopoietins and Angiopoietin-Like Proteins in Angiogenesis
Endothelium: Journal of Endothelial Cell Research, 2006Vascular network formation requires several endothelial cell growth factors. These factors have a potent angiogenic effect, and their precise coordination is essential for vascular development. Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling.
Yoshiaki Kubota +2 more
exaly +3 more sources
Angiopoietin inhibitors: A review on targeting tumor angiogenesis.
European Journal of Pharmacology, 2021Angiogenesis is the process of formation of new blood vessels from existing ones. Vessels serve the purpose of providing oxygen, nutrients and removal of waste from the cells.
Digna Parmar, M. Apte
semanticscholar +1 more source
Cancer Letters, 2013
Tie-1 and Tie-2 tyrosine kinase receptors are expressed specifically on vascular endothelial cells and on a certain subtype of macrophages implicated in angiogenesis, thus, they have been a major focus of angiogenesis research. Tie-1 and Tie-2 are essential for vascular maturation during developmental, physiological and pathological angiogenesis ...
Fagiani, E., Christofori, G.
openaire +4 more sources
Tie-1 and Tie-2 tyrosine kinase receptors are expressed specifically on vascular endothelial cells and on a certain subtype of macrophages implicated in angiogenesis, thus, they have been a major focus of angiogenesis research. Tie-1 and Tie-2 are essential for vascular maturation during developmental, physiological and pathological angiogenesis ...
Fagiani, E., Christofori, G.
openaire +4 more sources
European Journal of Surgical Oncology (EJSO), 2007
Tumour growth is dependant upon the development of an adequate blood supply. This, in turn, is thought to depend upon a switch by the tumour, from a dormant to angiogenic state. Recent data suggest that this switch may occur when the balance of pro- and anti-angiogenic agents alters to promote angiogenesis. Angiopoietins may be involved in this balance.
F, Bach, F J, Uddin, D, Burke
openaire +2 more sources
Tumour growth is dependant upon the development of an adequate blood supply. This, in turn, is thought to depend upon a switch by the tumour, from a dormant to angiogenic state. Recent data suggest that this switch may occur when the balance of pro- and anti-angiogenic agents alters to promote angiogenesis. Angiopoietins may be involved in this balance.
F, Bach, F J, Uddin, D, Burke
openaire +2 more sources
Angiopoietin-Related/Angiopoietin-Like Proteins Regulate Angiogenesis
International Journal of Hematology, 2004A general understanding of the molecular mechanisms underlying angiogenesis is emerging from the analysis of targeted mutations in vasculature-related genes. These analyses reveal that angiopoietin signaling through the TIE2 receptor is involved in regulating angiogenesis.
Toshio Suda
exaly +3 more sources
Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma
Journal of Hepatology, 2004Hepatocellular carcinoma (HCC) is a highly vascular tumor. Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. We investigated the expression of Angiopoietin-1 and Angiopoietin-2 in HCC.The expression of Angiopoietin-1 and Angiopoietin-2 mRNAs in cultured hepatoma cells under hypoxic conditions and in HCC and ...
Takuji, Torimura +13 more
openaire +2 more sources
Angiopoietin-1 and Angiopoietin-2 Inhibitors: Clinical Development
Current Oncology Reports, 2019The purpose of this review is to discuss the current understanding of the Tie2-angiopoietin system and its role in tumor growth and metastasis. This review also focuses on preclinical and clinical data published to date that have evaluated Tie2-angiopoietin inhibition.Tie2 inhibition has shown significant promise in preclinical models, notable for ...
Jessica, Gillen +2 more
openaire +2 more sources
Tie-2/Angiopoietin pathway modulation as a therapeutic strategy for retinal disease
Expert Opinion on Investigational Drugs, 2019Introduction: The Tie-2/Angiopoietin pathway is a therapeutic target for the treatment of neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME).
Rehan M. Hussain +4 more
semanticscholar +1 more source
2009
The formation of new blood vessels plays an important role during the development and progression of a disease. In recent years, there has been a tremendous effort to uncover the molecular mechanisms that drive blood vessel growth in adult tissues. Angiopoietins belong to a family of growth factors that are critically involved in blood vessel formation
openaire +2 more sources
The formation of new blood vessels plays an important role during the development and progression of a disease. In recent years, there has been a tremendous effort to uncover the molecular mechanisms that drive blood vessel growth in adult tissues. Angiopoietins belong to a family of growth factors that are critically involved in blood vessel formation
openaire +2 more sources
Angiopoietin signaling in the vasculature
Experimental Cell Research, 2013The angiopoietin (Ang) growth factors and the endothelial Tie receptors regulate blood and lymphatic vessel development, and vascular permeability, inflammation, angiogenic remodeling and tumor vascularization in adult tissues. The angiopoietins activate the Tie receptors in unique in trans complexes at endothelial cell-cell and cell-matrix contacts ...
Lauri, Eklund, Pipsa, Saharinen
openaire +2 more sources