Results 261 to 270 of about 57,083 (310)

Role of angiopoietin-2 in inflammatory autoimmune diseases: A comprehensive review.

International Immunopharmacology, 2020
Angiogenesis is defined as the growth of new capillaries sprouting from pre-existing vasculature. Pathological angiogenesis signals can lead to dysregulated development of new vessels. Inflammation is accompanied by pathological angiogenesis.
Qian Wu, Wang-Dong Xu, An-Fang Huang
semanticscholar   +1 more source

Angiopoietin‐1/Tie‐2 signal after focal traumatic brain injury is potentiated by BQ788, an ETB receptor antagonist, in the mouse cerebrum: Involvement in recovery of blood–brain barrier function

Journal of Neurochemistry, 2020
Angiopoietin‐1, an angiogenic factor, stabilizes brain microvessels through Tie‐2 receptor tyrosine kinase. In traumatic brain injury, blood–brain barrier (BBB) disruption is an aggravating factor that induces brain edema and neuroinflammation.
Shotaro Michinaga, Ayami Tanabe, Ryusei Nakaya, Chihiro Fukutome, Anna Inoue, A. Iwane, Y. Minato, Yu Tujiuchi, Daisuke Miyake, H. Mizuguchi, Y. Koyama   +10 more
semanticscholar   +1 more source

Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2

Cytogenetic and Genome Research, 2001
The family of human angiopoietins comprises factors with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to the endothelial cell-specific receptor, Tie2. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting ...
E G, Ward, K, Grosios, A F, Markham, P F, Jones   +3 more
openaire   +2 more sources

Angiopoietins

2015
Copyright Holder: Springer-Verlag Berlin ...
openaire   +1 more source

Molecular control of angiopoietin signalling

Biochemical Society Transactions, 2011
The angiopoietins act through the endothelial receptor tyrosine kinase Tie2 to regulate vessel maturation in angiogenesis and control quiescence and stability of established vessels. The activating ligand, Ang1 (angiopoietin-1), is constitutively expressed by perivascular cells, and the ability of endothelial cells to respond to the ligand is ...
Singh, H, Tahir, TA, Alawo, DOA, Issa, E, Brindle, NPJ   +4 more
openaire   +4 more sources

Angiopoietin 2 signal complexity in cardiovascular disease and cancer.

Life Science, 2019
The angiopoietin signal transduction system is a complex of vascular-specific kinase pathways that plays a crucial role in angiogenesis and maintenance of vascular homeostasis. Angiopoietin1 (Ang1) and 2 (Ang2), the ligand proteins of the pathway, belong
G. Nicolini, F. Forini, C. Kusmic, G. Iervasi, S. Balzan   +4 more
semanticscholar   +1 more source

Angiopoietin-2 in CLL

Blood, 2010
Elevated plasma levels of the angiogenic factor Ang-2 correlated with poor prognosis in a larger series of CLL patients. Ang-2 levels may reflect crosstalk between CLL cells and their microenvironment, specifically related to angiogenesis and endothelial cells, and therefore emphasize the importance of angiogenesis in CLL. .
openaire   +2 more sources

Angiopoietin‐1 haploinsufficiency affects the endothelial barrier and causes hereditary angioedema

Clinical and Experimental Allergy, 2019
Different mutations of the angiopoietin‐1 gene (ANGPT1) have been associated with the occurrence of hereditary angioedema (HAE).
M. d'Apolito, R. Santacroce, A. Colia, G. Cordisco, A. Maffione, M. Margaglione   +5 more
semanticscholar   +1 more source

Balance between Angiopoietin-1 and Angiopoietin-2 Is in Favor of Angiopoietin-2 in Atherosclerotic Plaques with High Microvessel Density

Journal of Vascular Research, 2008
<i>Introduction:</i> Atherosclerotic plaque microvessels are associated with plaque hemorrhage and rupture. The mechanisms underlying plaque angiogenesis are largely unknown. Angiopoietin (Ang)-1 and -2 are ligands of the endothelial receptor Tie-2.
Simone, Post, Wouter, Peeters, Els, Busser, Dennis, Lamers, Joost P G, Sluijter, Marie-José, Goumans, Roel A, de Weger, Frans L, Moll, Pieter A, Doevendans, Gerard, Pasterkamp, Aryan, Vink   +10 more
openaire   +2 more sources

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

Science, 1997
P. Maisonpierre, C. Suri, P. F. Jones, S. Bartunkova, S. Wiegand, C. Radziejewski, D. Compton, J. Mcclain, T. H. Aldrich, N. Papadopoulos, T. Daly, S. Davis, T. Sato, G. Yancopouloš   +13 more
semanticscholar   +1 more source