Results 61 to 70 of about 57,083 (310)

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Effect of complete, lifelong ANGPTL3 deficiency on triglyceride-rich lipoprotein kinetics

Cell Reports Medicine
Summary: Angiopoietin-like 3 (ANGPTL3) inhibits lipases that hydrolyze triglycerides (TGs) in TG-rich lipoproteins (TRLs). We evaluated TRL-TGs, TRL particle (apolipoprotein B), palmitate, and glucose kinetics during a mixed-meal test that included ...
Alan Fappi, Bruce W. Patterson, Kendal H. Burks, Nicholas O. Davidson, Tomas Vaisar, Jenny E. Kanter, Karin E. Bornfeldt, Edward A. Fisher, Ira J. Goldberg, Nathan O. Stitziel, Bettina Mittendorfer   +10 more
doaj   +1 more source

PRDM16 regulates arterial development and vascular integrity

Frontiers in Physiology, 2023
Proper vascular formation is regulated by multiple signaling pathways. The vascular endothelial growth factor (VEGF) signaling promotes endothelial proliferation.
Michael Thompson, Michael Thompson, Masahide Sakabe, Masahide Sakabe, Mark Verba, Mark Verba, Jiukuan Hao, Stryder M. Meadows, Stryder M. Meadows, Q. Richard Lu, Q. Richard Lu, Mei Xin, Mei Xin   +12 more
doaj   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Angiopoietin-2 level as a tool for cardiovascular risk stratification in hypertensive type 2 diabetic subjects

, 2019
Objectives: This observational cross-sectional study aimed to investigate the relationship between serum Angiopoietin-2 (Ang-2) levels and cardiovascular (CVD) risk factors in drug controlled hypertensive diabetic subjects without cardiovascular ...
Shaik Sarfaraz Nawaz (5153894), Khalid Al-Rubeaan (526186), Khalid Siddiqui (5153888), Mohammad T. Al Otaibi (5153897), Salini Scaria Joy (5153891)   +4 more
core   +1 more source

Morphological assessment of angiogenesis factor expression in tumor and microenvironment of breast fibroadenoma and ductal carcinoma: An observational cohort study

Кубанский научный медицинский вестник
Background. Angiogenesis plays a crucial role in the progression of breast cancer. Identifying and investigating the key components of this process, focused on phenotype as well as microenvironment of the tumor, is considered highly relevant for ...
K. A. Aliyev, E. R. Asanova, T. P. Makalish, E. Yu. Zyablitskaya   +3 more
doaj   +1 more source

SnapShot: Angiopoietins and Their Functions

Cell, 2017
Angiopoietins signal through TIE receptors to control both developmental and homeostatic processes that can go awry in genetic diseases and cancer. This SnapShot illustrates key elements of angiopoietin signaling in normal and disease contexts.
Pipsa, Saharinen, Veli-Matti, Leppänen, Kari, Alitalo   +2 more
openaire   +2 more sources

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Antibody-based therapeutics and therapeutic development for diabetic retinopathy: targeting VEGF, Ang/Tie, and inflammatory pathways

Frontiers in Endocrinology
Diabetic retinopathy (DR), a leading cause of global blindness, represents a significant microvascular complication of diabetes mellitus. This comprehensive review examines the evolving landscape of monoclonal antibody (mAb) therapy in DR management. The
Yuan Zong, Yuan Zong, Yuan Zong, Shuang Qiu, Huang Zhang, Jiaxin Wu, Jiaxin Wu, Jingheng Du, Koju Kamoi, Zhimin Cen   +9 more
doaj   +1 more source

Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina

eLife, 2018
The maintenance of fluid homeostasis is necessary for function of the neural retina; however, little is known about the significance of potential fluid management mechanisms.
Harri Elamaa, Minna Kihlström, Emmi Kapiainen, Mika Kaakinen, Ilkka Miinalainen, Symantas Ragauskas, Marc Cerrada-Gimenez, Satu Mering, Marjut Nätynki, Lauri Eklund   +9 more
doaj   +1 more source