Results 201 to 210 of about 97,507,719 (246)

Angiopoietin-1 and Angiopoietin-2 Inhibitors: Clinical Development

Current Oncology Reports, 2019
The purpose of this review is to discuss the current understanding of the Tie2-angiopoietin system and its role in tumor growth and metastasis. This review also focuses on preclinical and clinical data published to date that have evaluated Tie2-angiopoietin inhibition.Tie2 inhibition has shown significant promise in preclinical models, notable for ...
Jessica, Gillen, Debra, Richardson, Kathleen, Moore   +2 more
openaire   +2 more sources

Angiopoietin-2: a biomarker in hyperthyroidism.

Theoretical biology forum, 2019
Serum angiopoietin-2 level is elevated in several diseases suggesting its possible role as a mediator of angiogenesis and vascular network remodeling. Triiodothyronine and thyroxine have well documented effects on angiogenesis in vitro, but only few reports have studied angiopoietin-2 in thyroid-disease patients.
Rudina, Ndreu, Valter, Lubrano, Laura, Sabatino, Andrea, Ripoli, Giorgio, Iervasi, Silvana, Balzan   +5 more
openaire   +2 more sources

Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2

Cytogenetic and Genome Research, 2001
The family of human angiopoietins comprises factors with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to the endothelial cell-specific receptor, Tie2. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting ...
E G, Ward, K, Grosios, A F, Markham, P F, Jones   +3 more
openaire   +2 more sources

Angiopoietin-2 in CLL

Blood, 2010
Elevated plasma levels of the angiogenic factor Ang-2 correlated with poor prognosis in a larger series of CLL patients. Ang-2 levels may reflect crosstalk between CLL cells and their microenvironment, specifically related to angiogenesis and endothelial cells, and therefore emphasize the importance of angiogenesis in CLL. .
openaire   +2 more sources

Balance between Angiopoietin-1 and Angiopoietin-2 Is in Favor of Angiopoietin-2 in Atherosclerotic Plaques with High Microvessel Density

Journal of Vascular Research, 2008
<i>Introduction:</i> Atherosclerotic plaque microvessels are associated with plaque hemorrhage and rupture. The mechanisms underlying plaque angiogenesis are largely unknown. Angiopoietin (Ang)-1 and -2 are ligands of the endothelial receptor Tie-2.
Simone, Post, Wouter, Peeters, Els, Busser, Dennis, Lamers, Joost P G, Sluijter, Marie-José, Goumans, Roel A, de Weger, Frans L, Moll, Pieter A, Doevendans, Gerard, Pasterkamp, Aryan, Vink   +10 more
openaire   +2 more sources

Regulation of the expression balance of angiopoietin-1 and angiopoietin-2 by Shh and FGF-2

In Vitro Cellular & Developmental Biology - Animal, 2010
Sonic hedgehog (Shh) is a typical morphogen to regulate epithelial-mesenchymal interactions during embryonic development. Shh is also an indirect angiogenic agent upregulating other angiogenic factors, including angiopoietin-1 (Ang-1). Recent studies revealed that angiogenesis induced by Shh is characterized by distinct large-diameter vessels with less
Takaaki, Fujii, Hiroyuki, Kuwano
openaire   +2 more sources

Plasma concentrations of angiopoietin-1, angiopoietin-2 and Tie-2 in colon cancer

European Cytokine Network, 2012
despite the rapidly accumulating histopathological data reporting differences in the expression of members of the angiopoietin family on the surface of various normal and tumour cells, data for these growth factors in plasma from cancer patients, including colon cancer, are scarce. The aims of the present study were to measure the plasma concentrations
Ayla Gökmen, Yucel Ustundag, Ishak Ozel Tekin, Şehmuz ertop, Sevil Uygun Ilikhan, Hüseyin Engin   +5 more
openaire   +3 more sources

Dynamic changes in serum angiopoietin-1, angiopoietin-2, and angiopoietin-2/angiopoietin-1 ratio in acute myocardial infarction patients treated with primary percutaneous coronary intervention

Biomarkers, 2012
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) play divergent roles in myocardial ischemia and reperfusion injury.To investigate serum Ang-1 and Ang-2 levels in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).Serum Ang-1 and Ang-2 were measured in 85 STEMI patients in the ...
Ming Cui, Lijun Guo, Lin Mi
exaly   +3 more sources

Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality [PDF]

Intensive Care Medicine, 2009
Contains fulltext : 79899.pdf (Publisher’s version ) (Open Access)PURPOSE: To investigate whether angiopoietin-2, von Willebrand factor (VWF) and angiopoietin-1 relate to surrogate indicators of vascular permeability, pulmonary ...
Peter Pickkers, Geerten P van Nieuw Amerongen   +1 more
exaly   +2 more sources

Vitreous Levels of Angiopoietin-1 and Angiopoietin-2 in Eyes With Retinopathy of Prematurity

American Journal of Ophthalmology, 2011
To determine the vitreous levels of angiopoietin (Ang)-1 and Ang-2 in eyes with retinopathy of prematurity (ROP), and to determine the correlation between the 2 levels.Retrospective case-control study.Forty-eight eyes with stage 4 ROP were studied. Six eyes with congenital cataract were used as controls.
Tatsuhiko, Sato, Chiharu, Shima, Shunji, Kusaka   +2 more
openaire   +2 more sources