Results 141 to 150 of about 470,839 (363)
The Effect of ACE Inhibition on the Pulmonary Vasculature in Combined Models of Chronic Hypoxia and Pulmonary Arterial Banding in Sprague Dawley Rats [PDF]
, 2010 Microfocal CT was used to image the pulmonary arterial (PA) tree in rodent models of pulmonary hypertension (PH). CT images were used to measure the arterial tree diameter along the main arterial trunk at several hydrostatic intravascular pressures and ...
Baumgardt, Shelley +2 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims To assess the utility of the artificial intelligence (AI) chatbot ChatGPT (openly available version 3.5) in responding to real‐world pharmacotherapeutic queries from healthcare professionals. Methods Three independent and blinded evaluators with different levels of medical expertise and professional experience (beginner, advanced, and expert ...
Benjamin Krichevsky +9 more
wiley +1 more source
Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants
Nutrients, 2017 Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension.
Ceren Daskaya‐Dikmen +4 more
semanticscholar +1 more source
Chemically Synthesized LRAD3‐D1 Interacts with N‐Terminal Domain of SARS‐CoV‐2 Spike Protein
ChemBioChem, EarlyView.Chemical synthesis, calcium‐templated in‐vitro folding and competitive ELISA assay reveal that only domain 1 of the LRAD3 ectodomain interacts with the severe acute respiratory syndrome‐related corona virus 2 (SARS‐CoV‐2) spike NTD, while domains 2 and 3 do not, providing valuable insight into ACE2‐independent viral entry pathways that may contribute ...
Mrinmoy Jana +5 more
wiley +1 more source
Effect of renin angiotensin blockers on angiotensin converting enzyme 2 level in cardiovascular patients [PDF]
, 2023 Sarah Fahmy +4 more
openalex +1 more source
Antioxidant and antihypertensive activities of rice bran peptides [PDF]
, 2011 Protein isolates and peptide fractions from food sources (cereal grains), have been shown to exert bioactive properties including antiobesity, anticancer, antiangiogenic, etc.
Hettiarachchy, Navam S. +2 more
core +2 more sources
Method Overview for Discovering ATE1 Substrates and their Arginylation Sites
ChemBioChem, EarlyView.Arginylation is a decades‐old post‐translational modification but is inherently difficult to study. A plurality of methods have been developed and deployed to uncover the biology and substrates of this modification. This review covers the history, major advancements, and substrates discovered over the course of six decades.
Richard M. Searfoss +2 more
wiley +1 more source
Research Progress on the Mechanism of Action of Food-Derived ACE-Inhibitory Peptides
LifeHypertension is a major pathogenic contributor to cardiovascular diseases, primarily mediated through activation of the angiotensin-converting enzyme (ACE) system.
Ting Li +6 more
doaj +1 more source
Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives
ChemPlusChem, EarlyView.Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu +21 more
wiley +1 more source