Results 141 to 150 of about 456,743 (411)
Left Ventricular Dysfunction in Patients Receiving Cardiotoxic Cancer Therapies Are Clinicians Responding Optimally? [PDF]
, 2010 ObjectivesThe purpose of this study was to examine treatment practices for cancer therapy-associated decreased left ventricular ejection fraction (LVEF) detected on echocardiography and whether management was consistent with American College of ...
Carlson, Robert W. +5 more
core +1 more source
Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models
Animal Models and Experimental Medicine, EarlyView.We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv +12 more
wiley +1 more source
Structures, Functions, and Mechanisms of Filament Forming Enzymes: A Renaissance of Enzyme Filamentation [PDF]
arXiv, 2019 Filament formation by non-cytoskeletal enzymes has been known for decades, yet only relatively recently has its wide-spread role in enzyme regulation and biology come to be appreciated. This comprehensive review summarizes what is known for each enzyme confirmed to form filamentous structures in vitro, and for the many that are known only to form large
arxiv
, 2000 Angiotensin-converting-enzyme inhibitors improve the outcome among patients with left ventricular dysfunction, whether or not they have heart failure. We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at ...
S. Yusuf +5 more
semanticscholar +1 more source
European Respiratory Journal, 2018 Pulmonary arterial hypertension (PAH) is a deadly disease with no cure. Alternate conversion of angiotensin II (AngII) to angiotensin-(1–7) (Ang-(1–7)) by angiotensin-converting enzyme 2 (ACE2) resulting in Mas receptor (Mas1) activation improves rodent ...
A. Hemnes +21 more
semanticscholar +1 more source
RAMIPRIL IN THERAPY OF PATIENTS AFTER MYOCARDIAL INFARCTION
Рациональная фармакотерапия в кардиологии, 2015 Angiotensin converting enzyme inhibitors are the first line medicine for the treatment of the most of cardiovascular diseases. There is no class-effect for these drugs in myocardial infarction therapy.
I. V. Szirov, E. V. Malichenko
doaj +3 more sources
Effect of short time captopril administration on spatial memory in aging rats [PDF]
, 2015 Introduction: The brain renin-angiotensin system (RAS) has been reported having a pathological role in age-related impairment in learning and memory. Therefore, angiotensin converting enzyme inhibitors (ACEi) are expected to have positive ef fects on ...
Bakhshandeh, F., Ganji, F., Sepehri, H.
core
Mitigation of Radiation Induced Pulmonary Vascular Injury by Delayed Treatment with Captopril [PDF]
, 2012 Background and Objective: A single dose of 10 Gy radiation to the thorax of rats results in decreased total lung angiotensin-converting enzyme (ACE) activity, pulmonary artery distensibility and distal vascular density while increasing pulmonary ...
Fish, Brian L. +5 more
core +2 more sources
Angewandte Chemie International Edition, Accepted Article.This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley +1 more source
The Application of Clinical Genetics, 2019 Mohanad Yasir Al-Radeef,1 Hayder Adnan Fawzi,2 Ali Abdulmajid Allawi31Department of Clinical Pharmacy, College of Pharmacy, Tikrit University, Tikrit, Iraq; 2Department of Clinical Pharmacy, Baghdad Medical City Hospital, Baghdad, Iraq; 3Department of ...
Al-Radeef MY, Fawzi HA, Allawi AA
doaj