Results 11 to 20 of about 462,118 (388)

Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension

Journal of the Renin-Angiotensin-Aldosterone System, 2023
Hypertension is a major risk factor for heart attack, produce atherosclerosis (hardening of the arteries), congestive heart failure, stroke, kidney infection, blindness, end-stage renal infection, and cardiovascular diseases. Many mechanisms are involved
Hafiz Ahmad, Huma Khan, S. Haque, Shameem Ahmad, N. Srivastava, Azhar Khan   +5 more
semanticscholar   +1 more source

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Intensive Care Medicine, 2020
A novel infectious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in Wuhan, China, in December 2019. The disease (COVID-19) spread rapidly, reaching epidemic proportions in China, and has been found in 27 ...
Haibo Zhang, J. Penninger, Yimin Li, N. Zhong, Arthur S Slutsky   +4 more
semanticscholar   +1 more source

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

European Journal of Clinical Microbiology and Infectious Diseases, 2021
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell surfaces through which SARS-CoV-2 enters the host cells and is highly expressed in the ...
Stephany Beyerstedt, E. B. Casaro, É. B. Rangel   +2 more
semanticscholar   +1 more source

Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in ...
Peng Zhang, Lihua Zhu, Jingjing Cai, Fang Lei, Juan-Juan Qin, Jing Xie, Ye Liu, Yan-Ci Zhao, Xuewei Huang, Lijin Lin, Meng Xia, Ming-Ming Chen, Xu Cheng, Xiao Zhang, D. Guo, Yuanyuan Peng, Yan‐Xiao Ji, J. Chen, Zhi‐Gang She, Yibin Wang, Qingbo Xu, Renfu Tan, Hai-tao Wang, Jun Lin, Pengcheng Luo, Shouzhi Fu, Hongbing Cai, P. Ye, B. Xiao, W. Mao, Liming Liu, You-qin Yan, Mingyu Liu, Manhua Chen, Xiao-Jing Zhang, Xinghuan Wang, R. Touyz, J. Xia, Bing-Hong Zhang, Xiaodong Huang, Yufeng Yuan, L. Rohit, Peter P. Liu, Hongliang Li   +43 more
semanticscholar   +1 more source

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19

Critical Care, 2020
An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic.
W. Ni, Xiuwen Yang, Deqing Yang, J. Bao, Ran Li, Yongjiu Xiao, C. Hou, Haibin Wang, Jie Liu, Dong-hong Yang, Yu Xu, Zhaolong Cao, Zhancheng Gao   +12 more
semanticscholar   +1 more source

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

Circulation Research, 2020
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe acute respiratory ...
Mahmoud Gheblawi, Kaiming Wang, A. Viveiros, Quynh Nguyen, J. Zhong, A. Turner, M. Raizada, M. Grant, G. Oudit   +8 more
semanticscholar   +1 more source

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Nature Network Boston, 2005
During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world. A new coronavirus (SARS-CoV) was identified as the SARS pathogen, which triggered severe pneumonia and acute ...
K. Kuba, Y. Imai, Shuan Rao, Hong Gao, F. Guo, Bin Guan, Yi Huan, Peng‐fei Yang, Yanli Zhang, Wei Deng, L. Bao, Binlin Zhang, Guang Liu, Z. Wang, M. Chappell, Yan-xin Liu, D. Zheng, A. Leibbrandt, T. Wada, Arthur S Slutsky, De-Pei Liu, C. Qin, Chengyu Jiang, J. Penninger   +23 more
semanticscholar   +1 more source

Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19)

Journal of Pathology, 2020
Angiotensin‐converting enzyme 2 (ACE2) has been established as the functional host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus responsible for the current devastating worldwide pandemic of coronavirus disease 2019
A. Bourgonje, A. Abdulle, Wim Timens, J. Hillebrands, G. Navis, Sanne J Gordijn, M. Bolling, Gerard Dijkstra, A. Voors, Albert Osterhaus, Peter H. J. van der Voort, D. J. Mulder, H. van Goor   +12 more
semanticscholar   +1 more source

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

Journal of Clinical Investigation, 1990
A polymorphism consisting of the presence or absence of a 250-bp DNA fragment was detected within the angiotensin I-converting enzyme gene (ACE) using the endothelial ACE cDNA probe. This polymorphism was used as a marker genotype in a study involving 80
B. Rigat, C. Hubert, F. Alhenc-Gelas, F. Cambien, P. Corvol, F. Soubrier   +5 more
semanticscholar   +1 more source

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults.

Journal of the American Medical Association (JAMA), 2020
This study compares angiotensin-converting enzyme 2 (ACE2) gene expression, which has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adults.
S. Bunyavanich, Anh N. Do, A. Vicencio
semanticscholar   +1 more source