Results 31 to 40 of about 988,621 (236)

Protein-protein interactions of human somatic angiotensin-converting enzyme [PDF]

, 2011
In this study, novel disulphide bridges were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these ...
Gordon, Kerry
core   +1 more source

A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity

Brazilian Journal of Medical and Biological Research, 2005
A continuous assay using internally quenched fluorescent peptides with the general sequence Abz-peptidyl-(Dnp)P-OH (Abz = ortho-aminobenzoic acid; Dnp = 2,4-dinitrophenyl) was optimized for the measurement of angiotensin I-converting enzyme (ACE) in ...
M.F. Alves, M.C. Araujo, M.A. Juliano, E.M. Oliveira, J.E. Krieger, D.E. Casarini, L. Juliano, A.K. Carmona   +7 more
doaj   +1 more source

Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera

Hematology, 2023
Objective: Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. First-line therapies are directed at lowering hematocrit levels. After the discovery of a mutation in the Janus kinase 2 (JAK2V617F)
Angela Bozza, Martina Bernardi, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Giuseppe Astori   +5 more
doaj   +1 more source

Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? [PDF]

, 2005
Background Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant.
Montgomery, H, Harding, DR, Devadason David, Humphries, S, Whitelaw, A, David Davedason, Marlow Neil, Montgomery Hugh E, Marlow, N, Hugh E Montgomery, Davedason, D, Andrew Whitelaw, Humphries, SE, Neil Marlow, Montgomery, HE, Whitelaw Andrew, Humphries Steve E, Dhamrait Sukhbir, Devadason, D, Dhamrait, S, Steve E Humphries, Harding David R, David R Harding, Sukhbir Dhamrait   +23 more
core   +1 more source

DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. [PDF]

, 2012
The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD and cardiovascular disorders (CVD).
Eisenmenger, Wolfgang, Bondy, Brigitta, Mazza, Marianna, Zill, Peter, Clemens Früstück, Brigitta Bondy, Büttner, Andreas, Born, Christoph, Peter Zill, Andreas Büttner, Varallo-Bedarida, Gabriella, Cornelius Schüle, Früstück, Clemens, Rupprecht, Rainer, Möller, Hans-Jürgen, Schüle, Cornelius, Baghai, Thomas C., Wolfgang Eisenmenger, Christoph Born, Rainer Rupprecht, Hans-Jürgen Möller, Thomas C Baghai, Gabriella Varallo-Bedarida   +22 more
core   +1 more source

Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension

Physiological Reports, 2017
Obstructive sleep apnea is associated with hypertension and cardiovascular disease. Chronic intermittent hypoxia is used to model the arterial hypoxemia seen in sleep apnea patients and is associated with increased sympathetic nerve activity and a ...
Katelynn E. Faulk, T. Prashant Nedungadi, J. Thomas Cunningham   +2 more
doaj   +1 more source

ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice

Clinics, 2018
OBJECTIVES: The present study aimed to investigate cardiovascular autonomic modulation and angiotensin II (Ang II) activity in diabetic mice that were genetically engineered to harbor two or three copies of the angiotensin-converting enzyme gene ...
Oscar Albuquerque de Moraes, Karin Flues, Kátia Bilhar Scapini, Cristiano Mostarda, Fabiana de Sant’Anna Evangelista, Bruno Rodrigues, Daniela Ravizzoni Dartora, Patricia Fiorino, Kátia De Angelis, Maria Cláudia Irigoyen   +9 more
doaj   +1 more source

Evaluation of the Association between Multilobar Involvement and ACE Inhibitor Use in SARS-CoV-2 Patients

Haseki Tıp Bülteni, 2023
Aim:Angiotensin-converting enzyme 2 (ACE2) acts not only as an enzyme but also as a thought to be central receptor by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters host cells.
Dilay Satilmis, Burcu Genc Yavuz, Sahin Colak   +2 more
doaj   +1 more source

Isolation of Bat Sarbecoviruses, Japan

Emerging Infectious Diseases, 2022
Surveillance of bat betacoronaviruses is crucial for understanding their spillover potential. We isolated bat sarbecoviruses from Rhinolophus cornutus bats in multiple locations in Japan. These viruses grew efficiently in cells expressing R.
Shin Murakami, Tomoya Kitamura, Hiromichi Matsugo, Haruhiko Kamiki, Ken Oyabu, Wataru Sekine, Akiko Takenaka-Uema, Yuko Sakai-Tagawa, Yoshihiro Kawaoka, Taisuke Horimoto   +9 more
doaj   +1 more source

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey, McBride, Martin, Graham, Delyth, Nicklin, Stuart A., Masson, Rachel, Craig, Margaret Anne, Gregorevic, Paul, Napoli, Claudio, Dominiczak, Anna F., Allen, James M., Baker, Andrew H., Gilday, Kirsten, Chamberlain, Jeffrey S.   +12 more
core   +1 more source