Results 41 to 50 of about 462,118 (388)

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice

Nature Communications, 2020
Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) by the human cytokeratin 18 ...
Fatai S. Oladunni, Jun-Gyu Park, P. Pino, O. Gonzalez, A. Akhter, Anna Allué-Guardia, Angélica M. Olmo-Fontánez, S. Gautam, Andreu Garcia-Vilanova, C. Ye, Kevin Chiem, Colwyn A. Headley, V. Dwivedi, L. Parodi, K. Alfson, Hilary M Staples, Alyssa Schami, J. García, Alison Whigham, R. N. Platt, M. Gazi, Jesse C Martinez, Colin Chuba, S. Earley, Oscar H Rodriguez, S. Mdaki, Katrina N. Kavelish, Renee Escalona, C. Hallam, Corbett Christie, J. Patterson, T. Anderson, R. Carrion, E. Dick, Shannan Hall-Ursone, L. Schlesinger, X. Alvarez, D. Kaushal, L. Giavedoni, J. Turner, L. Martínez-Sobrido, J. Torrelles   +41 more
semanticscholar   +1 more source

A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity

Brazilian Journal of Medical and Biological Research, 2005
A continuous assay using internally quenched fluorescent peptides with the general sequence Abz-peptidyl-(Dnp)P-OH (Abz = ortho-aminobenzoic acid; Dnp = 2,4-dinitrophenyl) was optimized for the measurement of angiotensin I-converting enzyme (ACE) in ...
M.F. Alves, M.C. Araujo, M.A. Juliano, E.M. Oliveira, J.E. Krieger, D.E. Casarini, L. Juliano, A.K. Carmona   +7 more
doaj   +1 more source

Evaluation of the Association between Multilobar Involvement and ACE Inhibitor Use in SARS-CoV-2 Patients

Haseki Tıp Bülteni, 2023
Aim:Angiotensin-converting enzyme 2 (ACE2) acts not only as an enzyme but also as a thought to be central receptor by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters host cells.
Dilay Satilmis, Burcu Genc Yavuz, Sahin Colak   +2 more
doaj   +1 more source

Pharmacological effects of raas blockade in ischemic nephropathy [PDF]

, 2016
Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio, Cianci, Rosario, Coppolino, Giuseppe, Di Mario, Francesca, Farrah, Tariq E., Fuiano, Giorgio, Gigante, Antonietta, Rivoli, Laura, Rosato, Edoardo   +8 more
core   +1 more source

Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

Cellular & Molecular Immunology, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel corona virus disease (COVID-19). To date, no prophylactic vaccines or approved therapeutic agents are available for preventing and treating this highly
Xiangyu Chen, Ren Li, Zhiwei Pan, C. Qian, Yang Yang, Renrong You, J. Zhao, Pinghuang Liu, Leiqiong Gao, Zhirong Li, Qizhao Huang, Lifan Xu, Jianfang Tang, Qin Tian, W. Yao, Li Hu, Xiaofeng Yan, Xinyuan Zhou, Yuzhang Wu, K. Deng, Zheng Zhang, Zhaohui Qian, Yaokai Chen, L. Ye   +23 more
semanticscholar   +1 more source

Isolation of Bat Sarbecoviruses, Japan

Emerging Infectious Diseases, 2022
Surveillance of bat betacoronaviruses is crucial for understanding their spillover potential. We isolated bat sarbecoviruses from Rhinolophus cornutus bats in multiple locations in Japan. These viruses grew efficiently in cells expressing R.
Shin Murakami, Tomoya Kitamura, Hiromichi Matsugo, Haruhiko Kamiki, Ken Oyabu, Wataru Sekine, Akiko Takenaka-Uema, Yuko Sakai-Tagawa, Yoshihiro Kawaoka, Taisuke Horimoto   +9 more
doaj   +1 more source

Signaling by the Angiotensin-Converting Enzyme [PDF]

Circulation Research, 2006
Inhibition of the angiotensin-converting enzyme (ACE) protects against the progression of several cardiovascular diseases. Because of its dual role in regulating angiotensin II and bradykinin levels, the positive clinical effects of ACE inhibitors were thought to be the consequence of concomitant reductions in the production of angiotensin II and the ...
openaire   +3 more sources

Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19).

JAMA cardiology, 2020
Importance The role of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) in the setting of the coronavirus disease 2019 (COVID-19) pandemic is hotly debated.
N. Mehta, A. Kalra, A. Nowacki, Scott Anjewierden, Zheyi Han, Pavan Bhat, A. Carmona-Rubio, M. Jacob, G. Procop, S. Harrington, A. Milinovich, L. Svensson, L. Jehi, James B. Young, M. Chung   +14 more
semanticscholar   +1 more source

Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension

Physiological Reports, 2017
Obstructive sleep apnea is associated with hypertension and cardiovascular disease. Chronic intermittent hypoxia is used to model the arterial hypoxemia seen in sleep apnea patients and is associated with increased sympathetic nerve activity and a ...
Katelynn E. Faulk, T. Prashant Nedungadi, J. Thomas Cunningham   +2 more
doaj   +1 more source

ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice

Clinics, 2018
OBJECTIVES: The present study aimed to investigate cardiovascular autonomic modulation and angiotensin II (Ang II) activity in diabetic mice that were genetically engineered to harbor two or three copies of the angiotensin-converting enzyme gene ...
Oscar Albuquerque de Moraes, Karin Flues, Kátia Bilhar Scapini, Cristiano Mostarda, Fabiana de Sant’Anna Evangelista, Bruno Rodrigues, Daniela Ravizzoni Dartora, Patricia Fiorino, Kátia De Angelis, Maria Cláudia Irigoyen   +9 more
doaj   +1 more source