Results 91 to 100 of about 206,964 (305)

Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2

Revista Información Científica, 2021
Introduction: COVID-19 caused by the SARS-CoV-2 virus is a pandemic that has claimed the lives of millions of people and overloaded health services around the world.
María Teresa Díaz-Armas, Rolando Sánchez-Artigas, Tamia Zaadé Matute-Respo, Ronny Alexander Llumiquinga-Achi   +3 more
doaj  

Imbalance Between Pulmonary Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Activity in Acute Respiratory Distress Syndrome

, 2013
Objective: Angiotensin-converting enzyme and its effector peptide angiotensin II have been implicated in the pathogenesis of acute respiratory distress syndrome. Recently, angiotensin-converting enzyme 2 was identified as the counter-regulatory enzyme of
Kamilic, Jelena, Bruijn, Martijn, van den Berg, Elske, Bos, Albert P., Bem, Reinout A., Dierdorp, Barbara S., Dekker, Tamara, van Goor, Harry, Wosten-van Asperen, Roelie M., van Woensel, Job B., van der Loos, Chris M., Bos, Albert, Lutter, Rene, van Goor, Harry; id_orcid   +13 more
core   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials

Frontiers in Medicine, 2020
Angiotensin-converting enzyme 2 (ACE2) is the receptor for COVID-19 (SARs-CoV-2). ACE2 protects the lung and heart from acute respiratory distress syndrome (ARDS) and acute myocarditis and arrhythmias, because it breaks down Angiotensin II, which has ...
Eugenie R. Lumbers, Eugenie R. Lumbers, Eugenie R. Lumbers, Sarah J. Delforce, Sarah J. Delforce, Sarah J. Delforce, Kirsty G. Pringle, Kirsty G. Pringle, Kirsty G. Pringle, Gary R. Smith   +9 more
doaj   +1 more source

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

, 2006
Includes bibliographical references.Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin
Chitapi, Itai
core  

The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with OSA: a meta-analysis

, 2014
Obstructive sleep apnoea (OSA) is an independent risk factor for hypertension. Increased angiotensin-converting enzyme (ACE) activity may be a possible promoting mechanism with different ACE insertion/deletion (I/D) genotypes influencing this activity ...
李佩玲, Lee, Peilin;Douglas, Neil J.;Riha, Renata L.   +1 more
core   +1 more source

Beyond right or wrong: How partial credit scoring on multiple‐choice questions improves student performance and assessment perceptions

British Journal of Clinical Pharmacology, EarlyView.
Aims In this study, we examined the effects of assigning partial credit to selected answer choices on student performance and perceptions in a pharmacology course using Type A multiple‐choice questions (MCQs). Methods Partial credit scoring was incorporated into quizzes and exams in a 10‐week pharmacology course for postbaccalaureate premedical ...
Stephen D. Schneid, Chris Armour, Katharina Brandl   +2 more
wiley   +1 more source

Angiotensin-Converting Enzyme 2 (ACE2) in Disease Pathogenesis

Circulation Journal, 2010
Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin-angiotensin system by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. For instance, in the acute respiratory distress syndrome (ARDS)
Imai, Yumiko, Kuba, Keiji, Ohto-Nakanishi, Takayo, Penninger, Josef M.   +3 more
openaire   +3 more sources

Protein-protein interactions of human somatic angiotensin-converting enzyme

, 2011
In this study, novel disulphide bridges were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these ...
Gordon, Kerry
core  

Secondary prevention of coronary heart disease in older patients after the national service framework: population based study [PDF]

, 2006
Objective To examine the extent of uptake of medication for secondary prevention of coronary heart disease in older British men and women before (1998-2001) and after (2003) the implementation of the national service framework.Design Two population based,
Morris, RW, Whincup, Peter H, Whincup, PH, Morris, Richard W, Papacosta, O, Ramsay, Sheena E, Ebrahim, S, Lawlor, Debbie A, Thomas, Mary C, Thomas, MC, Lennon, Lucy T, Lawlor, DA, Ramsay, SE, Lennon, LT, Ebrahim, Shah, Papacosta, Olia   +15 more
core   +1 more source