Angiotensin-converting enzyme 2 activation attenuates inflammation and oxidative stress in brain death donor followed by rat lung transplantation. [PDF]
Oliveira-Melo P +11 more
europepmc +1 more source
Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system. [PDF]
Zhao BW +4 more
europepmc +1 more source
Angiotensin-converting enzyme 2 and AMPK/mTOR pathway in the treatment of liver fibrosis: Should we consider further implications? [PDF]
Barone M.
europepmc +1 more source
Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVID-19. [PDF]
Jacobs AK +9 more
europepmc +1 more source
Synthesis, molecular docking, and <i>in vitro</i> activity of a novel angiotensin-converting enzyme 2 inhibitor, LMS1007: a potential molecule in Covid-19 and cancer treatments. [PDF]
Saadah L +3 more
europepmc +1 more source
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Angiotensin-converting enzyme (ACE) catalyzes the formation of angiotensin II (Ang II), a vasoconstrictor, whereas its homologue ACE2 degrades Ang II into angiotensin (1-7) (Ang (1-7)), a vasodilator. Given the similarities in structure and their interconnected roles in the regulation of cardiovascular system, this study aims to investigate if ACE ...
Zihan Wang +3 more
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Angiotensin converting enzyme 2 and atherosclerosis
Atherosclerosis, 2013Angiotensin converting enzyme 2 (ACE2) is a homolog of angiotensin converting enzyme (ACE) which generates angiotensin II from angiotensin I. ACE, its product angiotensin II and the downstream angiotensin type I receptor are important components of the renin-angiotensin system (RAS). Angiotensin II, the most important component of the RAS, promotes the
Wang, Yutang +3 more
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Angiotensin converting enzyme 2 and the kidney
Current Opinion in Nephrology and Hypertension, 2016Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that metabolizes angiotensin II (AngII). AngII levels can be modulated by ACE2 in tissues where the enzyme is highly expressed, such as the kidney. In the kidney, ACE2 has the potential to regulate the intrarenal renin-angiotensin system (RAS), which can impact blood pressure and renal ...
David I, Ortiz-Melo, Susan B, Gurley
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Angiotensin-converting enzyme 2: a key enzyme in key organs
Journal of Cardiovascular Medicine, 20212020 marked the 20th anniversary of the discovery of the angiotensin-converting enzyme 2 (ACE2). This major event that changed the way we see the renin–angiotensin system today could have passed quietly. Instead, the discovery that ACE2 is a major player in the severe acute respiratory syndrome coronavirus 2 pandemic has blown
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