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Angiotensin-I-Converting Enzyme (ACE) Inhibitors from Marine Resources: Prospects in the Pharmaceutical Industry

Marine Drugs, 2010
Hypertension or high blood pressure is one of the major independent risk factors for cardiovascular diseases. Angiotensin-I-converting enzyme (EC 3.4.15.1; ACE) plays an important physiological role in regulation of blood pressure by converting ...
Isuru Wijesekara, Se-Kwon Kim
doaj   +3 more sources

Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE

Frontiers in Aging Neuroscience, 2023
IntroductionAlzheimer’s disease (AD) is associated with amyloid β-protein 1-42 (Aβ42) accumulation in the brain. Aβ42 and Aβ40 are the major two species generated from amyloid precursor protein.
Yuan Gao, Yang Sun, Sadequl Islam, Tomohisa Nakamura, Taisuke Tomita, Kun Zou, Makoto Michikawa   +6 more
doaj   +1 more source

Small molecule angiotensin converting enzyme inhibitors: A medicinal chemistry perspective

Frontiers in Pharmacology, 2022
Angiotensin-converting enzyme (ACE), a zinc metalloprotein, is a central component of the renin–angiotensin system (RAS). It degrades bradykinin and other vasoactive peptides.
Wenyue Zheng, Wenyue Zheng, Erkang Tian, Zhen Liu, Changhan Zhou, Pei Yang, Pei Yang, Keyue Tian, Wen Liao, Juan Li, Changyu Ren   +10 more
doaj   +1 more source

Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

eLife, 2020
The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and ...
Gian Paolo Rossi, Viola Sanga, Matthias Barton   +2 more
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Learning and Investigation of the Role of Angiotensin-Converting Enzyme in Radiotherapy for Nasopharyngeal Carcinoma

Biomedicines, 2023
Ionizing radiation (IR) is an important treatment for nasopharyngeal carcinoma (NPC) that mainly kills tumor cells by producing large amounts of reactive oxygen species (ROS). Intracellular ROS levels affect the sensitivity of tumor cells to IR. Recently,
Yanan Ding, Huanhuan Xiu, Yanling Zhang, Miaola Ke, Letao Lin, Huzheng Yan, Pan Hu, Meigui Xiao, Xu He, Tao Zhang   +9 more
doaj   +1 more source

Thymosin-α1 binds with ACE and downregulates the expression of ACE2 in human respiratory epithelia

Frontiers in Bioscience-Landmark, 2022
Background: Thymosin-α1 has been implicated into the treatment of novel respiratory virus Coronavirus Disease 2019 (COVID-19), but the underlying mechanisms are still disputable.
Yu-Hang Zhang, Wen-Yu Wang, Xiao-Cong Pang, Zhi Wang, Cheng-Zhuo Wang, Hang Zhou, Bo Zheng, Yi-Min Cui   +7 more
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Cereals as a Source of Bioactive Compounds with Anti-Hypertensive Activity and Their Intake in Times of COVID-19

Foods, 2022
Cereals have phytochemical compounds that can diminish the incidence of chronic diseases such as hypertension. The angiotensin-converting enzyme 2 (ACE2) participates in the modulation of blood pressure and is the principal receptor of the virus SARS-CoV-
Abigail García-Castro, Alma Delia Román-Gutiérrez, Araceli Castañeda-Ovando, Raquel Cariño-Cortés, Otilio Arturo Acevedo-Sandoval, Patricia López-Perea, Fabiola Araceli Guzmán-Ortiz   +6 more
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Influence of renin‐angiotensin‐aldosterone system inhibitors on plasma levels of angiotensin‐converting enzyme 2

ESC Heart Failure, 2021
Aims Concern has been raised that treatment with angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers may increase the expression of angiotensin‐converting enzyme 2 (ACE2), which acts as the entry receptor for SARS‐CoV‐2, and lead ...
Tobias Zimmermann, Joan Elias Walter, Pedro Lopez‐Ayala, Ivo Strebel, Melissa Amrein, Michael Koechlin, Ursina Honegger, Christian Mueller, BASEL VIII Investigators   +8 more
doaj   +1 more source

Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade

Case Reports in Nephrology, 2020
The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna, Venu Madhav Konala, Subhasish Bose, Sasmit Roy, Bhaskar Reddy Madhira, Vijay Gayam, Srikanth Naramala, Sreedhar Adapa   +7 more
doaj   +1 more source

Angiotensin converting enzyme 2 (ACE2) - the major receptor for SARS-CoV-2 virus [PDF]

Farmacja Polska, 2021
The renin-angiotensin-aldosterone system (RAS) plays a significant role in the regulation of the water and electrolyte balance. Renin from the kidneys converts angiotensinogen to angiotensin I. Angiotensin converting enzyme (ACE) catalyzes the conversion
Sonia Frankowska, Karolina Zając, Klaudia Zargaryan, Jolanta Barbara Zawilska   +3 more
doaj   +1 more source