Results 131 to 140 of about 190,682 (162)

Calcitriol regulates angiotensin-converting enzyme and angiotensin converting-enzyme 2 in diabetic kidney disease

Molecular Biology Reports, 2016
To investigate the effects of calcitriol on angiotensin-converting enzyme (ACE) and ACE2 in diabetic nephropathy. Streptozotocin (STZ) induced diabetic rats were treated with calcitriol for 16 weeks. ACE/ACE2 and mitogen activated protein kinase (MAPK) enzymes were measured in the kidneys of diabetic rats and rat renal tubular epithelial cells exposed ...
Mei, Lin, Ping, Gao, Tianya, Zhao, Lei, He, Mengshi, Li, Yaoyao, Li, Hua, Shui, Xiaoyan, Wu   +7 more
openaire   +2 more sources

Angiotensin-converting enzyme 2 and renal disease

Current Opinion in Nephrology and Hypertension, 2018
The renin-angiotensin system (RAS) is a pivotal player in the physiology and pathophysiology of cardiovascular and renal systems. Discovery of angiotensin-converting enzyme 2 (ACE2), capable of cleaving RAS effector peptide angiotensin (Ang) II into biologically active Ang-(1-7), has increased the complexity of our knowledge of the RAS. ACE2 expression
Vanessa R, Williams, James W, Scholey
openaire   +2 more sources

Urinary angiotensin‐converting enzyme 2 in patients with CKD

Nephrology, 2011
ABSTRACT:Aim:  Angiotensin‐converting enzyme 2 (ACE2) is a type I membrane protein that antagonizes the action of angiotensin II. Because of the need for invasive kidney biopsy, little is known about the role of renal ACE2 in human kidney diseases. The authors studied if urinary ACE2 could provide a novel clue to renal ACE2 in chronic kidney disease ...
Sonoo, Mizuiri, Toshiyuki, Aoki, Hiromichi, Hemmi, Michitsune, Arita, Ken, Sakai, Atsushi, Aikawa   +5 more
openaire   +2 more sources

Angiotensin-converting enzyme 2-independent action of presumed angiotensin- converting enzyme 2 activators

2016
The renin-angiotensin system (RAS) constitutes one of the pivotal systems in the physiological regulation of blood pressure and volume homeostasis. The balance between the classical Angiotensin-converting enzyme (ACE) – Angiotensin II (Ang II) – Angiotensin type 1 receptor (AT1R) axis, promoting vasoconstriction, and the antagonistic Angiotensin ...
openaire   +1 more source

Identification of angiotensin converting enzyme 2 in the rodent retina

Current Eye Research, 2004
An active renin-angiotensin system has been found in the retina of rats and humans. Angiotensin-converting enzyme 2 (ACE2) is a recently discovered enzymatic homologue of Angiotensin-converting enzyme (ACE) that may be an important new component of the renin-angiotensin system (RAS).
Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W., Thomas, M. C., Lew, R. A., Yarski, M., Smith, A. I., Cooper, M. E.   +8 more
openaire   +5 more sources

Angiotensin-Converting Enzyme 2 — A New Cardiac Regulator

New England Journal of Medicine, 2002
The renin–angiotensin system is a master regulator of human physiology. It controls blood pressure and fluid and electrolyte balance through coordinated effects on the heart, blood vessels, and kid...
Manfred, Boehm, Elizabeth G, Nabel
openaire   +2 more sources

The emerging role of angiotensin-converting enzyme-2 in the kidney

Current Opinion in Nephrology and Hypertension, 2007
The intrarenal renin-angiotensin system contributes to the progression of chronic kidney disease. Angiotensin-converting enzyme-2 is a recently identified protein that is highly expressed in the kidney and results in formation of angiotensin-(1-7). This manuscript highlights current information on the localization and function of angiotensin-converting
openaire   +2 more sources

Angiotensin-converting enzyme 2

2004
Nigel M. Hooper, Anthony J. Turner
openaire   +1 more source

Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19

Circulation Research, 2020
Lijin Lin, Jiahong Xia, Zhi-Gang She
exaly  

Angiotensin-Converting Enzyme Is Involved in Outside-In Signaling in Endothelial Cells

Circulation Research, 2004
Ralf P Brandes, Werner Müller-Esterl, Íngrid Fleming   +2 more
exaly