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Angiotensin converting enzyme 2 and atherosclerosis
Atherosclerosis, 2013 Angiotensin converting enzyme 2 (ACE2) is a homolog of angiotensin converting enzyme (ACE) which generates angiotensin II from angiotensin I. ACE, its product angiotensin II and the downstream angiotensin type I receptor are important components of the renin-angiotensin system (RAS). Angiotensin II, the most important component of the RAS, promotes the
Wang, Yutang +3 more
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Journal of Agricultural and Food Chemistry, 2023
Angiotensin-converting enzyme (ACE) catalyzes the formation of angiotensin II (Ang II), a vasoconstrictor, whereas its homologue ACE2 degrades Ang II into angiotensin (1-7) (Ang (1-7)), a vasodilator. Given the similarities in structure and their interconnected roles in the regulation of cardiovascular system, this study aims to investigate if ACE ...
Zihan Wang +3 more
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Angiotensin-converting enzyme (ACE) catalyzes the formation of angiotensin II (Ang II), a vasoconstrictor, whereas its homologue ACE2 degrades Ang II into angiotensin (1-7) (Ang (1-7)), a vasodilator. Given the similarities in structure and their interconnected roles in the regulation of cardiovascular system, this study aims to investigate if ACE ...
Zihan Wang +3 more
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Angiotensin converting enzyme 2 and the kidney
Current Opinion in Nephrology and Hypertension, 2016Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that metabolizes angiotensin II (AngII). AngII levels can be modulated by ACE2 in tissues where the enzyme is highly expressed, such as the kidney. In the kidney, ACE2 has the potential to regulate the intrarenal renin-angiotensin system (RAS), which can impact blood pressure and renal ...
David I, Ortiz-Melo, Susan B, Gurley
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Angiotensin-converting enzyme 2: a key enzyme in key organs
Journal of Cardiovascular Medicine, 20212020 marked the 20th anniversary of the discovery of the angiotensin-converting enzyme 2 (ACE2). This major event that changed the way we see the renin–angiotensin system today could have passed quietly. Instead, the discovery that ACE2 is a major player in the severe acute respiratory syndrome coronavirus 2 pandemic has blown
Pasquale, Pagliaro +3 more
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Molecular Biology Reports, 2016
To investigate the effects of calcitriol on angiotensin-converting enzyme (ACE) and ACE2 in diabetic nephropathy. Streptozotocin (STZ) induced diabetic rats were treated with calcitriol for 16 weeks. ACE/ACE2 and mitogen activated protein kinase (MAPK) enzymes were measured in the kidneys of diabetic rats and rat renal tubular epithelial cells exposed ...
Mei, Lin +7 more
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To investigate the effects of calcitriol on angiotensin-converting enzyme (ACE) and ACE2 in diabetic nephropathy. Streptozotocin (STZ) induced diabetic rats were treated with calcitriol for 16 weeks. ACE/ACE2 and mitogen activated protein kinase (MAPK) enzymes were measured in the kidneys of diabetic rats and rat renal tubular epithelial cells exposed ...
Mei, Lin +7 more
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Angiotensin-converting enzyme 2 and renal disease
Current Opinion in Nephrology and Hypertension, 2018The renin-angiotensin system (RAS) is a pivotal player in the physiology and pathophysiology of cardiovascular and renal systems. Discovery of angiotensin-converting enzyme 2 (ACE2), capable of cleaving RAS effector peptide angiotensin (Ang) II into biologically active Ang-(1-7), has increased the complexity of our knowledge of the RAS. ACE2 expression
Vanessa R, Williams, James W, Scholey
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Urinary angiotensin‐converting enzyme 2 in patients with CKD
Nephrology, 2011ABSTRACT:Aim: Angiotensin‐converting enzyme 2 (ACE2) is a type I membrane protein that antagonizes the action of angiotensin II. Because of the need for invasive kidney biopsy, little is known about the role of renal ACE2 in human kidney diseases. The authors studied if urinary ACE2 could provide a novel clue to renal ACE2 in chronic kidney disease ...
Sonoo, Mizuiri +5 more
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2016
The renin-angiotensin system (RAS) constitutes one of the pivotal systems in the physiological regulation of blood pressure and volume homeostasis. The balance between the classical Angiotensin-converting enzyme (ACE) – Angiotensin II (Ang II) – Angiotensin type 1 receptor (AT1R) axis, promoting vasoconstriction, and the antagonistic Angiotensin ...
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The renin-angiotensin system (RAS) constitutes one of the pivotal systems in the physiological regulation of blood pressure and volume homeostasis. The balance between the classical Angiotensin-converting enzyme (ACE) – Angiotensin II (Ang II) – Angiotensin type 1 receptor (AT1R) axis, promoting vasoconstriction, and the antagonistic Angiotensin ...
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Identification of angiotensin converting enzyme 2 in the rodent retina
Current Eye Research, 2004An active renin-angiotensin system has been found in the retina of rats and humans. Angiotensin-converting enzyme 2 (ACE2) is a recently discovered enzymatic homologue of Angiotensin-converting enzyme (ACE) that may be an important new component of the renin-angiotensin system (RAS).
Tikellis, C. +8 more
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Angiotensin-Converting Enzyme 2 — A New Cardiac Regulator
New England Journal of Medicine, 2002The renin–angiotensin system is a master regulator of human physiology. It controls blood pressure and fluid and electrolyte balance through coordinated effects on the heart, blood vessels, and kid...
Manfred, Boehm, Elizabeth G, Nabel
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