Results 261 to 270 of about 365,351 (311)

Angiotensin II Receptor Subtypes

American Journal of Hypertension, 1992
The octapeptide, angiotensin II (Ang II), the biologically active component of the renin-angiotensin system, elicits its multiple actions through the stimulation of specific surface receptors on various target organs. Although the existence of Ang II receptor subtypes has been suspected for some time, definitive evidence for Ang II receptor ...
P B, Timmermans, A T, Chiu, W F, Herblin, P C, Wong, R D, Smith   +4 more
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Angiotensin II and atherosclerosis

The American Journal of Cardiology, 2001
Numerous clinical and laboratory data are now available supporting the hypothesis that the renin-angiotensin system is mechanistically relevant in the pathogenesis of atherosclerosis. The traditional role of the renin-angiotensin system in the context of blood pressure regulation has been modified to incorporate the concept that angiotensin II (Ang II)
D, Weiss, D, Sorescu, W R, Taylor
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Angiotensin II

Journal of Cardiovascular Pharmacology, 1991
The consequence of a sustained rise in blood pressure is an adaptive change in the structure of the heart and the vasculature. In humans, the left ventricle, aorta, and medium-sized arteries undergo hypertrophy whereas the changes in resistance vessels are unclear at present.
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Angiotensin II-Generating Enzymes

Biochemistry (Moscow), 2000
The renin--angiotensin system (RAS) is a system of enzymes and hormones that regulate blood pressure and electrolyte and fluid homeostasis in mammals. Angiotensin II (Ang-II) is one of the most important and well-known components of RAS. It is formed from the protein precursor angiotensinogen by the sequential actions of proteolytic enzymes.
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Experimental angiotensin II hypertension

American Journal of Physiology-Heart and Circulatory Physiology, 1980
The mechanisms by which angiotensin II (AII) produces hypertension was studied in a group of 13 large dogs maintained on a Na intake of 200 meq/day. AII was infused at 10 ng x kg-1 x min-1 iv for 8 days. Arterial pressure increased from the control level of 98 +/- 3 to 160 +/- 7 mmHg and cardiac output fell significantly from the control value of 3.4 +
D B, Young, R H, Murray, R G, Bengis, A K, Markov   +3 more
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The Angiotensin II Receptor and the Actions of Angiotensin II

Journal of Cardiovascular Pharmacology, 1990
Angiotensin II (Ang II) is a potent effector peptide of the renin-angiotensin system that exerts a wide variety of physiological actions on the cardiovascular, renal, endocrine, and central and peripheral nervous systems. Angiotensin exerts its actions by binding to specific receptors in the plasma membrane of various tissues.
M J, Peach, D E, Dostal
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Conversion of Angiotensin I to Angiotensin II

Nature, 1967
Results obtained with the blood bathed organ technique indicate that angiotensin I is converted rapidly to angiotensin II in the pulmonary circulation and not by an enzyme in the blood.
K K, Ng, J R, Vane
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Angiotensin II Receptor Assays

Current Protocols in Pharmacology, 1998
AbstractThis unit describes the use of an isolated rabbit thoracic aorta preparation for determining the nature, potency, and selectivity of antagonists to the agonism of angiotensin II at AT1 receptors by measuring their effects on the tension of the tissue.
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Angiotensin II Blockade

New England Journal of Medicine, 1977
R E, Keenan, M L, Horne, V M, Conklin
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Conversion of angiotensin I to angiotensin II

The American Journal of Medicine, 1976
The angiotensin I converting enzyme has two important functions: it inactivates bradykinin and converts angiotensin I to angiotensin II. Inhibition of the enzyme blocks the renin-angiotensin system and decreases systemic blood pressure if the pressure is maintained or increased by renin. The enzyme occurs in a variety of tissues and cell forms.
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