Results 81 to 90 of about 5,964,638 (304)

Renin-Angiotensin-Aldosterone System in Heart Failure: Focus on Nonclassical Angiotensin Pathways as Novel Upstream Targets Regulating Aldosterone [PDF]

, 2019
Aldosterone plays an important role in the regulation of blood pressure, body fluid, and electrolyte homeostasis. Overactivation of aldosterone/mineralocorticoid receptor (MR) pathway leads to hypertension, atherosclerosis, vascular damage, heart failure,
Mariola Olkowicz, Urszula Tyrankiewicz, Chłopicki, Stefan, Olkowicz, Mariola, Smolenski, Ryszard T., Ryszard T. Smolenski (7951544), Agnieszka Kij, Tyrankiewicz, Urszula, Mariola Olkowicz (3189765), Stefan Chlopicki, Stefan Chlopicki (522371), Urszula Tyrankiewicz (7951541), Mohaissen, Tasnim, Ryszard T. Smolenski, Kij, Agnieszka, Tasnim Mohaissen, Agnieszka Kij (761459), Tasnim Mohaissen (5078378)   +17 more
core   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Angiotensin II Directly Increases Endothelial Calcium and Nitric Oxide in Kidney and Brain Microvessels In Vivo With Reduced Efficacy in Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The vasoconstrictor effects of angiotensin II via type 1 angiotensin II receptors in vascular smooth muscle cells are well established, but the direct effects of angiotensin II on vascular endothelial cells (VECs) in vivo and the mechanisms ...
Alejandra Becerra Calderon, Urvi Nikhil Shroff, Sachin Deepak, Audrey Izuhara, Greta Trogen, Alicia A. McDonough, Susan B. Gurley, Jonathan W. Nelson, János Peti‐Peterdi, Georgina Gyarmati   +9 more
doaj   +1 more source

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li‐Juan Min, Hui‐Yu Bai, Bao‐Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan‐no, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi   +12 more
doaj   +1 more source

Hepatic Mitochondrial Renin-Angiotensin Systems [PDF]

, 2015
Introduction: The circulating renin-angiotensin system (RAS) was originally described as a key endocrine regulator of intravascular homeostasis; however, the existence of a local (tissue) RAS has become increasingly reported in a variety of tissues ...
Skipworth, JRA
core  

Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization

, 2005
Angiotensin II and aldosterone produce pro-arrhythmic effects by several mechanisms, including the modulation of voltage-dependent K(+) channels involved in human cardiac repolarization.
Tamargo Menéndez, Juan, Delpón Mosquera, María Eva, Caballero Collado, Ricardo, Gómez García, Ricardo, Núñez Fernández, Lucía   +4 more
core   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Role of lipoxygenase products in the effects of angiotensin II in the isolated aorta and perfused heart of the rat

Mediators of Inflammation, 1995
The objective of this study was to determine whether arachidonate metabolites are involved in the vasoconstrictive effects of angiotensin II in rats. In the isolated perfused heart, dexamethasone (4 mg/kg) significantly suppressed the maximal decreases ...
J. P. M. Dam, E. van den Worm, W. Vleeming, M. J. Post, A. J. Porsius, J. Wemer   +5 more
doaj   +1 more source

Inhibitory Effect of Trilinolein on Angiotensin Ii-Induced Cardiomyocyte Hypertrophy

, 2009
The myocardial protective effects of trilinolein, isolated from the Chinese herb Sanchi (Panax notoginseng), may be related to its antioxidant effects.
LEE, HORNG-MO;LEE, WEN-SEN;SHIH, NENG- LANG;CHEN, JIN-JER;CHAN, PAUL, 李宏謀;李文森;施能明;陳錦澤;陳保羅   +1 more
core  

Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia [PDF]

, 2008
Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long and slender cytoplasmic ...
McKee, Mary, Shum, Winnie Wai Chi, Breton, Sylvie, Brown, Dennis, Smith, Peter J.S., Da Silva, Nicolas   +5 more
core   +1 more source