Results 91 to 100 of about 5,964,638 (304)

Impact of Acute Functional Decline on Frailty and Mortality in Acutely Hospitalized Older Persons

AGING MEDICINE, EarlyView.
Older persons with acute functional decline are often severely frail. Male sex, cognitive impairment, diabetes mellitus type 2, cancer, hearing impairment, and nursing home living increase the risk of severe frailty or death and should be considered when person‐centered care is planned for hospitalized older people.
Ali Vahedi, Maria Eriksdotter, Hege Ihle‐Hansen, Torgeir Bruun Wyller, Anne Rita Øksengård, Brynjar Fure   +5 more
wiley   +1 more source

Angiotensin-(1–7) suppresses pyroptosis in cerebral endothelium to decrease blood–brain barrier permeability and cognitive impairments in sepsis

Journal of International Medical Research
Objective This study aimed to explore the influence of the angiotensin-(1–7)/Mas receptor and angiotensin II/angiotensin II type 1 receptor pathways on pyroptosis during sepsis and their subsequent effects on cognitive function.
Yongli Han, Hongguang Ding, Yirun Chen, Yin Wen, Huishan Zhu, Zhiwei Su, Jiaqi Tang, Hongke Zeng   +7 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.

PLoS ONE, 2012
BackgroundThe natural triterpenes, erythrodiol and uvaol, exert anti-inflammatory, vasorelaxing and anti-proliferative effects. Angiotensin II is a well-known profibrotic and proliferative agent that participates in the cardiac remodeling associated with
Ruben Martín, Maria Miana, Raquel Jurado-López, Ernesto Martínez-Martínez, Nieves Gómez-Hurtado, Carmen Delgado, Maria Visitación Bartolomé, José Alberto San Román, Claudia Cordova, Vicente Lahera, Maria Luisa Nieto, Victoria Cachofeiro   +11 more
doaj   +1 more source

Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? [PDF]

, 2005
Background Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant.
Montgomery, H, Harding, DR, Devadason David, Humphries, S, Whitelaw, A, David Davedason, Marlow Neil, Montgomery Hugh E, Marlow, N, Hugh E Montgomery, Davedason, D, Andrew Whitelaw, Humphries, SE, Neil Marlow, Montgomery, HE, Whitelaw Andrew, Humphries Steve E, Dhamrait Sukhbir, Devadason, D, Dhamrait, S, Steve E Humphries, Harding David R, David R Harding, Sukhbir Dhamrait   +23 more
core   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Impaired angiotensin II signaling in septic shock

Annals of Intensive Care
Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone system in critically ill patients. Emerging data suggest that this vital homeostatic system, which plays a crucial role in maintaining systemic and renal hemodynamics ...
Adrien Picod, Bruno Garcia, Dirk Van Lier, Peter Pickkers, Antoine Herpain, Alexandre Mebazaa, Feriel Azibani   +6 more
doaj   +1 more source

The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies

Mediators of Inflammation, 2009
Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. The regulation of arterial blood pressure was considered from its first description of the main mechanism involved.
Fabrizio Montecucco, Aldo Pende, François Mach   +2 more
doaj   +1 more source

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure [PDF]

, 2008
Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear.
Julian Thompson, Nicholas S Hopkinson, Anthony Kehoe, Hopkinson, NS, Humphries, SE, Mostafa Ghanei, Montgomery Hugh, Khoshbaten, A, Hopkinson Nicholas S, Soroush, MR, Hugh Montgomery, Thompson Julian, Hosseini-Khalili, AR, Steve E Humphries, Kehoe, A, Montgomery, H, Ghanei, M, Kehoe Anthony, Hosseini-khalili Ali, Khoshbaten A, A Khoshbaten, Mohammad Reza Soroush, Soroush Mohammad, Thompson, J, Humphries Steve E, Ghanei Mostafa, Ali Reza Hosseini-khalili   +26 more
core   +2 more sources

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source